Isifo semvubu

Isifo seWhipple yimeko enqabileyo echaphazela amathumbu amancinci. Oku kuthintela amathumbu amancinci ekuvumeleni izakhamzimba ukuba zidlule kuwo wonke umzimba. Oku kubizwa ngokuba yi-malabsorption.

Isifo se-Whipple sibangelwa kukosuleleka luhlobo lwebhaktiriya ebizwa UTropheryma whipplei. Esi sifo sichaphazela ikakhulu amadoda amhlophe akwiminyaka ephakathi.

Isifo se-Whipple sinqabile kakhulu. Imiba yomngcipheko ayaziwa.

Iimpawu zihlala ziqala kancinci. Intlungu edibeneyo yeyona mpawu ixhaphakileyo yokuqala. Iimpawu zosulelo lwesisu (GI) zihlala zisenzeka kwiminyaka eliqela kamva. Ezinye iimpawu zingabandakanya:

• Intlungu zesisu
• Urhudo
• Ifiva
• Ubumnyama besikhumba kwiindawo ezibonakalayo zomzimba
  
• Intlungu edibeneyo emaqatheni, emadolweni, kwiingqiniba, kwiminwe, okanye kwezinye iindawo
• Ukuphulukana nenkumbulo
• Utshintsho lwengqondo
• Ukuhla ukusinda

Umboneleli wezempilo uya kwenza uvavanyo lomzimba. Oku kungabonisa:

• Ukwandiswa kwamadlala e-lymph
• Ukumbombozela kwentliziyo
• Ukudumba kwizicubu zomzimba (i-edema)

Uvavanyo lokufumanisa isifo seWhipple lunokubandakanya:

• Gcwalisa ubalo lwegazi (CBC)
• Uvavanyo lwe-Polymerase chain reaction (PCR) ukukhangela intsholongwane ebangela isifo
• I-biopsy encinci yamathumbu
• I-endoscopy ephezulu ye-GI (ukujonga amathumbu ngombhobho oguqukayo, okhanyisiweyo kwinkqubo ebizwa ngokuba yi-enteroscopy)

Esi sifo sinokutshintsha iziphumo zolu vavanyo lulandelayo:

• Amanqanaba eAlbumin egazini
• Amafutha angabanjwanga kwizitulo (amanqatha amdaka)
• Ukufakwa emathunjini kohlobo lweswekile (d-xylose absorption)

Abantu abanesifo se-Whipple kufuneka bathathe ixesha elide i-antibiotics ukunyanga naziphi na izifo zengqondo kunye nenkqubo ye-nervous system. I-antibiotic ebizwa ngokuba yi-ceftriaxone inikwa nge-vein (IV). Ilandelwa yenye i-antibiotiki (enje nge-trimethoprim-sulfamethoxazole) ethathwe ngomlomo ukuya kuthi ga kunyaka omnye.

Ukuba iimpawu ziyabuya ngexesha lokusetyenziswa kweyeza, amayeza anokutshintshwa.

Umboneleli wakho kufuneka alandele ngokusondeleyo inkqubela yakho. Iimpawu zesi sifo zingabuya emva kokuba ulugqibile unyango. Abantu abahlala bengondlekanga kuya kufuneka bathathe izongezo zokutya.

Ukuba ayinyangwa, imeko ihlala ibulala. Unyango luthomalalisa iimpawu kwaye luyasinyanga isifo.

Iingxaki zinokubandakanya:

• Umonakalo wobuchopho
• Umonakalo wentliziyo (ukusuka kwi-endocarditis)
• Ukuswela ukutya
• Iimpawu ziyabuya (ezinokubangelwa kukunganyangeki ngamachiza)
• Ukuhla ukusinda

Fowunela umnikezeli wakho ukuba unayo:

• Intlungu edibeneyo engahambi
• Intlungu zesisu
• Urhudo

Ukuba unyangwa isifo seWhipple, tsalela umnikezeli wakho ukuba:

• Iimpawu ziba mandundu okanye zingaphucuki
• Iimpawu ziyavela kwakhona
• Iimpawu ezintsha ziyavela

I-lipodystrophy yamathumbu emathunjini

UMaiwald M, von Herbay A, Relman DA. Isifo semvubu. Ku: UFeldman M, uFriedman LS, uBrandt LJ, ii-eds. Sleisenger kunye neFordtran's Gastrointestinal and Liver Disease. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 109.

UMarth T, isifo seSchneider T. Whipple. Ku: Bennett JE, Dolin R, Blaser MJ, ii-eds. Mandell, Douglas, kunye neBennett's Principles and Practice of Infectious Diseases. Umhla we-9. IPhiladelphia, PA: Elsevier; I-2020: isahluko 210.

ENtshona SG. Izifo zenkqubo yesifo apho isifo samathambo sisici. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 259.