Ukuqonda iSchoolsler Progressive Multiple Sclerosis

Umxholo

• Yintoni i-SPMS?
• Ukubuyela kwakhona kwe-MS kuba yi-SPMS
• Ukuchonga i-SPMS
• Ukunyanga i-SPMS
• Uvavanyo lwezonyango
• Inkqubela phambili
• Iinguqulelo
• Izinto ozilindile emhlabane
• Imbonakalo ye-SPMS

Yintoni i-SPMS?

I-multiple sclerosis eqhubekayo yesibini (SPMS) luhlobo lwe-multiple sclerosis. Iqwalaselwa kwinqanaba elilandelayo emva kokubuyela kwakhona kwi-MS (RRMS).

Nge-SPMS, akusekho miqondiso yoxolelo. Oku kuthetha ukuba imeko iya isiba mandundu nangona inyangwa. Nangona kunjalo, unyango luyacetyiswa ngamanye amaxesha ukunceda ukunciphisa uhlaselo kwaye ngethemba lokunciphisa inkqubo yokukhubazeka.

Eli nqanaba liqhelekile. Ngapha koko, uninzi lwabantu abane-MS luya kuphuhlisa i-SPMS ngaxa lithile ukuba alukho kunyango olusebenzayo lokuguqula isifo (i-DMT). Ukwazi imiqondiso ye-SPMS kunokukunceda ukuba uyibone kwangoko. Ngokukhawuleza ukuba unyango lwakho luqala, ngcono ugqirha uya kuba nakho ukukunceda ukunciphisa iimpawu ezintsha kunye nokugula kwesifo sakho.

Ukubuyela kwakhona kwe-MS kuba yi-SPMS

I-MS sisifo esinganyangekiyo sokuzimela komzimba esiza ngeendlela ezahlukeneyo kwaye sichaphazela abantu ngokwahlukileyo. Ngokuka-Johns Hopkins Medicine, malunga neepesenti ezingama-90 zabo bane-MS baqala ukufumanisa ukuba bane-RRMS.

Kwinqanaba le-RRMS, iimpawu zokuqala ezibonakalayo zibandakanya:

• ukuba ndindisholo okanye ukurhawuzelela
• ukungakwazi ukuzibamba (iingxaki zolawulo lwesinyi)
• utshintsho kumbono
• ubunzima bokuhamba
• ukudinwa kakhulu

Iimpawu zeRRMS zinokuza zihambe. Abanye abantu basenokungabi nazimpawu kwiiveki okanye kwiinyanga ezininzi, into ebizwa ngokuba luxolelo. Iimpawu ze-MS zinokubuya kwakhona, nangona oku kubizwa ngokuba yi-flare-up. Abantu banokuphuhlisa iimpawu ezintsha. Oku kubizwa ngokuba kukuhlaselwa, okanye ukubuyela umva.

Ukubuyela umva kuhlala kwiintsuku ezininzi ukuya kwiiveki ezininzi. Iimpawu zinokuya zisiba mandundu ekuqaleni kwaye emva koko ziphuhle kancinci kancinci ngaphandle kwexesha ngaphandle konyango okanye kungekudala nge-IV steroids. I-RRMS ayinakulinganiswa.

Ngexesha elithile, abantu abaninzi abane-RRMS abasenalo ixesha lokuxolelwa okanye ukubuyela umva ngesiquphe. Endaweni yoko, iimpawu zabo ze-MS ziyaqhubeka kwaye zisiba mbi ngaphandle kwekhefu.

Iyaqhubeka, iimpawu eziba mandundu zibonisa ukuba i-RRMS iqhubele phambili yaya kwi-SPMS. Oku kuhlala kwenzeka kwiminyaka eli-10 ukuya kweli-15 emva kweempawu zokuqala ze-MS. Nangona kunjalo, i-SPMS inokulibaziseka okanye inokuthi ithintelwe ukuba iqaliswe kwi-MS DMTs esebenzayo kwikhosi yesi sifo.

Iimpawu ezifanayo zikhona kuzo zonke iintlobo ze-MS. Kodwa iimpawu ze-SPMS ziqhubela phambili kwaye aziphucuki ngokuhamba kwexesha.

Ngexesha lokuqala kweRRMS, iimpawu ziyaqapheleka, kodwa azinyanzelekanga ngokwaneleyo ukuba ziphazamise imisebenzi yemihla ngemihla. Nje ukuba i-MS iqhubele phambili kwinqanaba lesibini lokuqhubela phambili, iimpawu ziye zibe ngumceli mngeni ngakumbi.

Ukuchonga i-SPMS

I-SPMS ikhula njengesiphumo sokulahleka kwe-neuronal kunye ne-atrophy. Ukuba uqaphela ukuba iimpawu zakho ziya zisiba mbi ngaphandle kokuxolelwa okanye ukubuyela umva kwakhona, ukuskena kwe-MRI kunokunceda kuxilongo.

Iskena se-MRI sinokubonisa inqanaba lokufa kweseli kunye ne-atrophy yengqondo. I-MRI iya kubonisa ukwanda okwahlukileyo ngexesha lohlaselo kuba ukuvuza kwee-capillaries ngexesha lokuhlaselwa kubangela ukuba kufumaneke ngakumbi idayi ye-gadolinium esetyenziswe kwisikali se-MRI.

Ukunyanga i-SPMS

I-SPMS iphawulwe ngokungabikho kokuphinda ubuye, kodwa kusenokwenzeka ukuba uhlaselo lweempawu, okwaziwa njenge-flare-up. Ama-flare-ups ahlala esibi kubushushu nakumaxesha oxinzelelo.

Okwangoku, kukho ii-DMTs ezili-14 ezisetyenziselwa ukubuyela kwiifom ze-MS, kubandakanya ne-SPMS eqhubeka nokubuyela umva. Ukuba uthatha elinye lala machiza ukunyanga i-RRMS, ugqirha wakho unokukufumana de ayeke ukulawula isifo.

Ezinye iintlobo zonyango zinokunceda ukuphucula iimpawu kunye nomgangatho wobomi. Oku kubandakanya:

• ulungiso lwenyama
• unyango lomsebenzi
• ukuzilolonga rhoqo
• ukuvuselelwa kwengqondo

Uvavanyo lwezonyango

Uvavanyo lwezonyango luvavanya iintlobo ezintsha zamayeza kunye nonyango kumavolontiya ukuze kuphuculwe unyango lwe-SPMS. Le nkqubo inika abaphandi umbono ocacileyo wento esebenzayo nekhuselekileyo.

Amavolontiya kuvavanyo lweklinikhi anokuba phakathi kwabokuqala ukufumana unyango olutsha, kodwa umngcipheko othile uyabandakanyeka. Unyango alunakunceda nge-SPMS, kwaye kwezinye iimeko, zinokuza nemiphumo emibi.

Ngokubalulekileyo, kufuneka kubekho izilumkiso ukugcina amavolontiya ekhuselekile, kunye nokukhusela iinkcukacha zawo.

Abathathi-nxaxheba kuvavanyo lweklinikhi ngokubanzi kufuneka bahlangane nezikhokelo ezithile. Xa uthatha isigqibo sokuba uthathe inxaxheba, kubalulekile ukubuza imibuzo enjengokuba ityala liza kuhlala ixesha elingakanani, nokuba ziziphi iziphumo ebezingalindelekanga ezinokubandakanya, kwaye kutheni abaphandi becinga ukuba izokunceda.

Iwebhusayithi yeSizwe ye-Multiple Sclerosis Society iluhlu lwezilingo e-United States, nangona ubhubhane we-COVID-19 usenokuba ulibazise izifundo ezicwangcisiweyo.

Uvavanyo lwezonyango oludweliswe njengokubamba kubandakanya enye ye-simvastatin, enokuthi icothise inkqubela phambili ye-SPMS, kunye nophando lokuba ingaba iintlobo ezahlukeneyo zonyango zinganceda abantu abane-MS ukulawula iintlungu.

Olunye uvavanyo lujolise ekuvavanyeni ukuba ngaba i-lipoic acid inokunceda abantu abane-MS ukuba baqhubeke nokuhamba kwaye bakhusele ingqondo.

Kwaye uvavanyo lweklinikhi lusetelwe ukugqitywa kamva kulo nyaka weeseli zeNurOwn. Injongo yayo kukuvavanya ukhuseleko kunye nokusebenza kwonyango lwe-stem yabantu kubantu abane-MS eqhubela phambili.

Inkqubela phambili

Ukuqhubela phambili kubhekisa kwiimpawu eziba mandundu ngokuhamba kwexesha. Ngamanye amanqaku, i-SPMS inokuchazwa njenge "ngaphandle kokuqhubela phambili," oko kuthetha ukuba ayibonakali ngathi iya isiba mandundu.

Ukuqhubela phambili kuyahluka kakhulu phakathi kwabantu abane-SPMS. Ekuhambeni kwexesha, abanye banokufuna ukusebenzisa isitulo esinamavili, kodwa abantu abaninzi bahlala bekwazi ukuhamba, mhlawumbi besebenzisa induku okanye isihambahamba.

Iinguqulelo

Izilungiso yimigaqo ebonisa ukuba i-SPMS yakho iyasebenza okanye ayisebenzi.Oku kunceda ukwazisa incoko nogqirha wakho malunga nonyango olunokwenzeka kunye nento onokuyilindela ukuya phambili.

Umzekelo, kwimeko ye-SPMS esebenzayo, unokuxoxa ngeendlela ezintsha zonyango. Ngokwahlukileyo, ngokungabikho komsebenzi, wena kunye nodokotela wakho unokuxoxa ngokusebenzisa ukulungiswa kunye neendlela zokulawula iimpawu zakho kunye ne-DMT enobungozi obuncinci.

Izinto ozilindile emhlabane

Umndilili wokulindelwa kobomi kubantu abane-MS buhlala bumalunga neminyaka esi-7 bufutshane kunabantu ngokubanzi. Akucaci ngokupheleleyo ukuba kutheni.

Ngaphandle kweemeko ezinzima ze-MS, ezinqabileyo, izizathu eziphambili zibonakala njengezinye iimeko zonyango ezichaphazela abantu ngokubanzi, njengomhlaza kunye nesifo sentliziyo kunye nemiphunga.

Ngokubalulekileyo, ixesha lokuphila kwabantu abane-MS lenyukile kumashumi eminyaka akutshanje.

Imbonakalo ye-SPMS

Kubalulekile ukunyanga i-MS ukulungiselela ukulawula iimpawu kunye nokunciphisa ukwanda kokukhubazeka. Ukufumanisa nokunyanga i-RRMS kwangethuba kunokunceda ukunqanda ukuqala kwe-SPMS, kodwa akukabikho lunyango.

Nangona esi sifo siza kuqhubeka, kubalulekile ukunyanga i-SPMS kwangoko. Akukho lunyango, kodwa i-MS ayibulali, kwaye unyango lunga phucula kakhulu umgangatho wobomi. Ukuba unayo i-RRMS kwaye uqaphela ukuba mandundu kweempawu, lixesha lokuba uthethe nogqirha wakho.