ITacrolimus

Umxholo

• Ngaphambi kokuba uthathe ityrolimus,
• I-Tacrolimus inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, okanye ezo zikhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Tacrolimus kufuneka inikezwe kuphela phantsi kweliso likagqirha onamava ekunyangeni abantu abanokufakelwa komzimba kunye nokumisela amayeza anciphisa umsebenzi wamajoni omzimba.

I-Tacrolimus inciphisa umsebenzi wamajoni akho omzimba. Oku kunokunyusa umngcipheko wokuba ufumane usulelo olubi. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: umqala obuhlungu; ukukhohlela; ifiva; ukudinwa kakhulu; iimpawu ezifana nomkhuhlane; ulusu olufudumeleyo, olubomvu, okanye olubuhlungu; okanye ezinye iimpawu zosulelo.

Xa amajoni akho omzimba engasebenzi ngesiqhelo, kunokubakho umngcipheko omkhulu wokuba ube nomhlaza, ngakumbi i-lymphoma (uhlobo lomhlaza oluqala kwiiseli zomzimba). Ngokude uthatha i-tacrolimus okanye amanye amayeza anciphisa umsebenzi wamajoni omzimba, kunye nokuphakamisa amanani akho ala mayeza, kokukhona lo mngcipheko unokunyuka. Ukuba ufumana naziphi na kwezi mpawu zilandelayo ze-lymphoma, biza ugqirha wakho ngokukhawuleza: i-lymph nodes ezivuvukileyo entanyeni, emakhwapheni, okanye kwi-groin; ukuhla ukusinda; ifiva; ukubila ebusuku; ukudinwa kakhulu okanye ubuthathaka; ukukhohlela; ingxaki yokuphefumla; iintlungu zesifuba; okanye iintlungu, ukudumba, okanye ukugcwala kwindawo yesisu.

Izifundo zibonise ukuba abasetyhini abafumene ukufakelwa isibindi kwaye babethatha ii-tacrolimus ezandisiweyo zokukhutshwa kweepilisi (i-Astagraf XL) babenomngcipheko wokufa. I-Tacrolimus eyandisiweyo-yokukhupha iicapsule (i-Astagraf XL) ayivunyelwanga yi-FDA ukuthintela ukwaliwa (ukuhlaselwa kwelungu elifakelweyo ngamajoni omzimba womntu ofumana ilungu) lokufakelwa kwesibindi.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-tacrolimus.

I-Tacrolimus (i-Astagraf XL, i-Envarsus XR, i-Prograf) isetyenziswa kunye namanye amayeza ukuthintela ukwaliwa (ukuhlaselwa komzimba otyalwe ngamajoni omzimba womntu ofumana ilungu) kubantu abafumene ukufakelwa kwezintso. I-Tacrolimus (Prograf) ikwasetyenziswa kunye namanye amayeza ukuthintela ukwaliwa kubantu abafumene isibindi okanye ukufakelwa kwentliziyo. I-Tacrolimus ikudidi lwamayeza abizwa ngokuba zii-immunosupressants. Isebenza ngokunciphisa umsebenzi wamajoni omzimba ukukhusela ekuhlaseleni ilungu elifakelweyo.

I-Tacrolimus iza njengecapsule, iigranu zokumiswa ngomlomo (ukuba zixutywe nolwelo), ukukhutshwa okwandisiweyo (ukubamba ixesha elide), kunye nethebhulethi yokukhupha eyandisiweyo ekufuneka uyithathe ngomlomo. Iifomsile zokukhululwa kwangoko (Prograf) kunye nokumiswa ngomlomo (Prograf) zihlala zithathwa kabini ngemini (iiyure ezili-12 ukwahlukana). Unokuthatha iifomsile zokukhululwa kwangoko kunye nokumiswa ngomlomo nokuba ungatya, kodwa qiniseka ukuyithatha ngendlela efanayo ngalo lonke ixesha. Iicapsule zokukhupha ezandisiweyo (i-Astagraf XL) okanye iipilisi zokukhupha ezandisiweyo (i-Envarsus XR) zihlala zithathwa rhoqo kusasa kwisisu esingenalutho ubuncinci kwiyure enye ngaphambi okanye kwisidlo sakusasa okanye ubuncinci iiyure ezi-2 emva kwesidlo sakusasa. Thatha i-tacrolimus ngaxeshanye (ii) mihla le. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-tacrolimus ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uthatha igranules zokumiswa ngomlomo, kuya kufuneka uyidibanise nobushushu begumbi ngaphambi kokusetyenziswa. Beka amacephe ayi-1 ukuya kwezi-2 (iimililitha ezili-15 ukuya kwezingama-30) zamanzi kwikomityi enamagriza. Xuba imixholo uze emva koko uthathe umxube ngomlomo kwikomityi okanye ngesirinji yomlomo; sukugcina lo mxube kwixesha elizayo. Iigranules aziyi kunyibilika ngokupheleleyo. Ukuba kukho nawuphi na umxube oseleyo, yongeza amacephe ayi-1 ukuya kwayi-2 (15 ukuya kuma-30 eemililitha) zamanzi kuloo mxube kwaye kwangoko uwuthathe

Ginya iicapsule zokukhupha ezandisiweyo kunye neepilisi ezandisiweyo zokukhupha amanzi; ungahluleli, ungahlaleli, okanye uzityumze. Sukuvula iicapsule zokukhululwa kwangoko,

Ugqirha wakho uya kukujonga ngononophelo kwaye ahlengahlengise idosi yakho njengoko kufuneka. Thetha nogqirha wakho rhoqo malunga nendlela oziva ngayo ngexesha lonyango lwakho. Buza ugqirha wakho ukuba unemibuzo malunga nokuba ungathatha itacrolimus engakanani.

Iimveliso ezahlukeneyo zetacrolimus zikhupha amayeza ngokwahlukileyo emzimbeni wakho kwaye azinakusetyenziswa ngokungafaniyo. Thatha kuphela imveliso ye-tacrolimus emiselweyo ngugqirha wakho kwaye ungatshintsheli kwimveliso eyahlukeneyo yetacrolimus ngaphandle kokuba ugqirha wakho uthi kufanele.

I-Tacrolimus inokuthintela kuphela ukwala ukufakelwa kwakho okoko nje usela amayeza. Qhubeka uthathe i-tacrolimus nokuba uziva uphilile. Ungayeki ukuthatha i-tacrolimus ngaphandle kokuthetha nogqirha wakho.

I-Tacrolimus ngamanye amaxesha isetyenziselwa ukunyanga isifo sikaCrohn (imeko apho umzimba uhlasela khona umgca wokugaya ukutya, ubangela iintlungu, urhudo, ukwehla kobunzima, umkhuhlane kunye nokwenziwa kweetonela ezingaqhelekanga ezidibanisa indlela yokugaya amanye amalungu okanye ulusu). Thetha nogqirha wakho malunga neengozi zokusebenzisa eli yeza ukunyanga imeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe ityrolimus,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-tacrolimus, nawaphi na amanye amayeza, okanye naziphi na ezinye izithako kwimveliso ye-tacrolimus. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone); amphotericin B (Abelcet, Ambisome); i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin, e Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (e Prinzide, e Zestoretic), moexipril (Univasc, in Unopic) , Prestalia), quinapril (Accupril, ngesiQuinaretic), ramipril (Altace), okanye trandolapril (eTarka); ii-antacids eziqukethe i-magnesium kunye nealuminium hayidroksayidi (Maalox); ii-antibiotics ezithile kubandakanya aminoglycosides anje nge-amikacin, gentamicin, neomycin (Neo-Fradin), streptomycin, kunye ne-tobramycin (Tobi), kunye nee-macrolides ezifana ne-clarithromycin (Biaxin), erythromycin (EES, E-Mycin, Erythrocin), kunye ne-troleandomycin (TA ayifumaneki e-US); amayeza okubola afana ne-clotrimazole (Lotrimin, Mycelex), fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), kunye ne-voriconazole (Vfend); i-angiotensin receptor blockers (ARBs) ezinje nge-azilsartan (Edarbi, e-Edarbyclor), i-candesartan (Atacand, e-Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, eAvalide), losartan (Cozaar, e-Hyzaar), olmesartan (Benicar eAzor, kwiBenicar HCT, eTribenzor), telmisartan (Micardis, eMicardis HCT, eTwynsta); i-boceprevir (iVictrelis; ayisafumaneki e-US); iicalcium block blockers ezinje nge-diltiazem (Cardizem), nicardipine, nifedipine (Adalat, Procardia), kunye ne-verapamil (Calan, Verelan, eTarka); iCaspofungin (Cancidas); ichloramphenicol; cimetidine (iTagamet); i-cisapride (iPropulsid; ayifumaneki kwi-US); icisisplatin; idanazol; i-diuretics ethile ('iipilisi zamanzi'); ganciclovir (Valcyte); ezinye izinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufaka, okanye inaliti); amayeza athile e-HIV afana ne-didanosine (Videx); indinavir (Crixivan), lamivudine (Epivir); nelfinavir (Viracept), ritonavir (Norvir), stavudine (Zerit), kunye ne-zidovudine (Retrovir) lansoprazole (Prevacid); imethylprednisolone (iMedrol); metoclopramide (Reglan); mycophenolate (Cellcept); nefazodone; omeprazole (Prilosec); uqikelelo; irifabutin (Mycobutin); irifampin (Rifadin, Rimactane); amayeza athile okubanjwa njenge carbamazepine (Tegretol, Teril), phenobarbital, kunye ne phenytoin (Dilantin, Phenytek); sirolimus (Rapamune), kunye ne telaprevir (Incivek; ayisafumaneki e U.S.). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akujonge ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-tacrolimus, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba uthatha okanye usandula ukuyeka ukuthatha i-cyclosporine (Gengraf, Neoral, Sandimmune). Ukuba uthatha i-cyclosporine, ugqirha wakho uya kuthi akuxelele ukuba ungaqali ukuthatha i-tacrolimus de kube ziiyure ezingama-24 emva kokuba uthathe idosi yakho yokugqibela ye-cyclosporine. Ukuba uyeka ukuthatha i-tacrolimus, ugqirha wakho uya kukuxelela ukuba ulinde iiyure ezingama-24 ngaphambi kokuba uqale ukuthatha i-cyclosporine.
• xelela ugqirha wakho kunye nosokhemisti ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort okanye i-schisandra sphenanthera extracts. Musa ukuthatha le mveliso yemveliso ngelixa uthatha i-tacrolimus.
• xelela ugqirha wakho ukuba unayo okanye wakha wanayo i-QT syndrome (imeko ezuzwe njengelifa apho umntu kunokwenzeka ukuba abe nokwandiswa kwe-QT) amanqanaba asezantsi e-potassium, calcium, okanye i-magnesium egazini lakho, ukubetha kwentliziyo okungaqhelekanga, amanqanaba aphezulu e-cholesterol, intliziyo , izintso, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba wena okanye iqabane lakho niyakwazi ukukhulelwa, sebenzisa ulawulo lokuzalwa olusebenzayo ngaphambi nangexesha lonyango nge-tacrolimus. Ukuba ukhulelwe ngelixa uthatha i-tacrolimus, biza ugqirha wakho. I-Tacrolimus inokulimaza umbungu.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-tacrolimus.
• Kuya kufuneka uyazi ukuba ukuthatha i-tacrolimus kungonyusa umngcipheko wokuba ube nomhlaza wolusu. Zikhusele kumhlaza wolusu ngokuphepha ukukhanya elangeni okungafunekiyo okanye ixesha elide okanye ukukhanya kwe-ultraviolet (iibhedi zokutshisa) kunye nokunxiba impahla ekhuselayo, iiglasi zelanga kunye nescreen selanga esikhusela isikhumba (SPF).
• ungaseli iziselo ezinxilisayo ngelixa usela ityrolimus njengeepilisi zokukhupha okanye ezandisiweyo. Utywala bunokwenza iziphumo ebezingalindelekanga zibe mbi ngakumbi.
• Kuya kufuneka uyazi ukuba itacrolimus inokubangela uxinzelelo lwegazi oluphezulu. Ugqirha wakho uza kujonga uxinzelelo lwegazi ngononophelo, kwaye unokuyalela amayeza ukunyanga uxinzelelo lwegazi oluphezulu ukuba luyakhula.
• Kuya kufuneka uyazi ukuba kukho umngcipheko wokuba uya kuba nesifo seswekile ngexesha lonyango lwakho nge-tacrolimus. Izigulana zase-Afrika zaseMelika nezaseSpain eziye zafakelwa ukufakelwa kwezintso zinomngcipheko omkhulu wokuba nesifo seswekile ngexesha lonyango lwazo ngetacrolimus. Tshela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho ukhe unesifo seswekile. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: ukunxanwa okugqithisileyo; ukulamba kakhulu; ukuchama rhoqo; ukungaboni kakuhle okanye ukudideka.
• awunalo ugonyo ngaphandle kokuthetha nogqirha wakho.

Gwema ukutya i-grapefruit okanye ukusela i-juice ye-grapefruit ngelixa uthatha itekisi.

Ukuba i-capsule yokukhululwa kwangoko okanye i-dose yokumiswa komlomo ilahlekile, yithathe ngokukhawuleza xa uyikhumbula. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba idosi ye-capsule eyandisiweyo ekhutshiweyo ilahlekile, thatha idosi ukuba ngaba ngaphakathi kweeyure ezili-14 emva kokulahleka kwethamo. Nangona kunjalo, ukuba ngaphezulu kweeyure ezili-14, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba idosi yethebhulethi ekhululweyo ikhutshiwe, yithathe ithamo ukuba ngaphakathi kweeyure ezili-15 emva kokulahleka kwedosi. Nangona kunjalo, ukuba ngaphezulu kweeyure ezili-15, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Tacrolimus inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• urhudo
• ukuqhina
• isicaphucaphu
• ukugabha
• isilungulela
• isisu esibuhlungu
• Ukuphelelwa ngumdla wokutya
• ubunzima bokulala okanye ukulala
• isiyezi
• ubuthathaka
• umqolo okanye iintlungu ezidibeneyo
• ukutshisa, ukuba ndindisholo, iintlungu, okanye ukubetha ezandleni okanye ezinyaweni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, okanye ezo zikhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza:

• ukuncipha kokuchama
• intlungu okanye ukutshisa xa uchama
• ukuphefumla okufutshane, urticaria, irhashalala, okanye ukurhawuzelela
• ulusu olumhlophe, ukuphefumla kancinci, okanye ukubetha kwentliziyo okukhawulezayo
• ukudinwa; ukutyeba kwakho; ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi; okanye ukuphefumla okufutshane
• ukopha okungaqhelekanga okanye ukugruzuka
• ukuxhuzula, ukutshintsha kombono, intloko ebuhlungu, ukudideka, okanye ukungcangcazela okungalawulekiyo kwilungu lomzimba
• isiqaqa (ukulahleka kwengqondo ixesha elithile)

I-Tacrolimus inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo.http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• urhwebo
• ukozela
• isicaphucaphu, ukugabha kunye norhudo
• ukushukuma okungalawulekiyo kwilungu lomzimba, intloko ebuhlungu, ukudideka, ukungalingani kunye nokudinwa kakhulu
• ukudumba kweengalo okanye imilenze
• umkhuhlane okanye ezinye iimpawu zosulelo

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-tacrolimus.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• I-Astagraf XL^®
• I-Envarsus XR^®
• Prograf^®

• FK 506