Umbhali: Janice Evans
Umhla Wokudalwa: 4 Eyekhala 2021
Hlaziya Umhla: 15 Eyenkanga 2024
Anonim
HIV therapy: Maraviroc. Mechanism of Action and Resistance【USMLE, Pharmacology】
Ividiyo: HIV therapy: Maraviroc. Mechanism of Action and Resistance【USMLE, Pharmacology】

Umxholo

IMaraviroc inokubangela ukonakala kwisibindi sakho. Unokufumana into ephikisayo kwi-maraviroc ngaphambi kokuba uhlakulele umonakalo wesibindi. Tshela ugqirha wakho ukuba unayo okanye uke waba ne-hepatitis okanye esinye isifo sesibindi. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, yeka ukuthatha i-maraviroc kwaye ubize ugqirha ngokukhawuleza: ubumthubi besikhumba okanye amehlo; umbala omnyama (umbala weti) umchamo; ukugabha; okanye iintlungu zangaphezulu esiswini.

I-Maraviroc inokubangela ukusabela okungafunekiyo emzimbeni, okunokubusongela ubomi. Ukuba ufumana irhashalala kunye nenye yezi mpawu zilandelayo, yeka ukuthatha i-maraviroc kwaye ubize ugqirha ngoko nangoko: isicaphucaphu; ifiva; iimpawu ezifana nomkhuhlane; iintlungu zemisipha okanye ngokudibeneyo; amadyunguza okanye izilonda emlonyeni; idumbile, ibomvu, iyaxobuka, okanye isikhumba esidumbileyo; ubomvu okanye ukudumba kwamehlo; ukudumba komlomo, ubuso, okanye imilebe; ubunzima bokuphefumla; iintlungu, iintlungu, okanye ukuthamba kwicala lasekunene ngezantsi kweembambo; okanye ukuphelelwa ngumdla wokutya.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-maraviroc.


Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-maraviroc kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-maraviroc.

IMaraviroc isetyenziswa kunye namanye amayeza ukunyanga uhlobo oluthile losulelo lwe-immunodeficiency virus (HIV) kubantu abadala nakubantwana abanobunzima obungama-4.4 lb (2 kg). IMaraviroc ikwiklasi yamayeza ekuthiwa yi-HIV entry kunye ne-fusion inhibitors. Isebenza ngokunciphisa inani le-HIV egazini. Nangona i-maraviroc ingayinyangi i-HIV, inokuwanciphisa amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezinzulu okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokuhambisa (ukusasaza) intsholongwane kagawulayo kwabanye abantu.


IMaraviroc iza njengecwecwe kunye nesisombululo (ulwelo) ekufuneka sithathe ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kabini ngemini. Thatha i-maraviroc malunga namaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-maraviroc kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuginya iipilisi ze-maraviroc ziphelele; ungahluleli, ungahlaleli, okanye uzityumze.

Sebenzisa enye yeesirinji zomlomo eze nonyango lokulinganisa isisombululo. Sebenzisa isirinji yomlomo encinci (3-mL) ukuba idosi yakho iyi-2.5 mL okanye ngaphantsi kwaye usebenzise isirinji yomlomo enkulu (10-mL) ukuba idosi yakho ingaphezulu kwe-2.5 mL. Buza ugqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo malunga nendlela yokulinganisa idosi yakho ngesirinji. Landela imiyalelo yomenzi malunga nendlela yokusebenzisa nokucoca isirinji yomlomo.

Ukuba unika isisombululo emntwaneni, beka incam yesirinji yomlomo emlonyeni womntwana ngokuchasene nangaphakathi esidleleni. Cothisa kancinci iplunger yonke indlela ukuya kunika onke amayeza kwisirinji yomlomo. Qinisekisa ukuba umntwana unexesha elaneleyo lokuginya isisombululo.


Qhubeka nokuthatha i-maraviroc nokuba uziva uphilile. Sukuyeka ukuthatha i-maraviroc ungakhange uthethe nogqirha wakho. Ukuba uphosa idosi, thatha ngaphantsi kwedosi emiselweyo, okanye uyeke ukuthatha i-maraviroc, imeko yakho kunokuba nzima ukuyinyanga. Xa unikezelo lwakho lwe-maraviroc luqala ukuba phantsi, fumana ngakumbi kugqirha wakho okanye kwikhemesti.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-maraviroc,

  • xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-maraviroc, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-maraviroc okanye isisombululo Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza okubola njenge ketoconazole (Nizoral) kunye neitraconazole (Onmel, Sporanox); i-clarithromycin (i-Biaxin, kwi-Prevpac); amayeza okunyanga i-HIV okanye i-AIDS; amayeza ukunyanga uxinzelelo lwegazi oluphezulu; idelalisib (iZydelig); amayeza athile anyanga ukuxhuzula okufana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), kunye ne phenytoin (Dilantin, Phenytek); nefazodone; I-ribociclib (Kisqali); irifabutin (Mycobutin); rifampin (Rifadin, Rimactane, Rifamate, abanye); kunye ne-telithromycin (ayisafumaneki e-US; Ketek). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
  • xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Akufanele uthathe i-wort yaseSt. John ngexesha lokunyanga kwakho nge-maraviroc.
  • xelela ugqirha wakho ukuba ukhe wanalo uxinzelelo lwegazi oluphantsi, iintlungu esifubeni, isifo seswekile, isifo sentliziyo, icholesterol ephezulu okanye amafutha egazini, okanye isifo sentliziyo okanye sezintso.
  • xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa uthatha i-maraviroc, tsalela ugqirha wakho. Akufanele uncancise xa wosulelwe yi-HIV okanye ukuba uthatha i-maraviroc.
  • Kuya kufuneka uyazi ukuba amanqatha omzimba wakho anokunyuka okanye ahambele kwiindawo ezahlukeneyo zomzimba wakho, ezinje ngamabele akho kunye nomqolo ongaphezulu, ngelixa uthatha i-maraviroc.
  • Kuya kufuneka uyazi ukuba i-maraviroc inokubangela ukuba ube nesiyezi, ukuba nentloko encinci, okanye ukubetha ngamandla xa usukuma ngokukhawuleza kwindawo oxokileyo kuyo. Ukunceda ukuthintela le ngxaki, phuma kancinci ebhedini, uphumle iinyawo zakho phantsi imizuzu embalwa ngaphambi kokuba ume. Musa ukuqhuba imoto okanye usebenzise oomatshini abanzima xa unesiyezi ngelixa usenza i-maraviroc.
  • Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho. Oku kunokubangela ukuba ube neempawu zolu sulelo. Ukuba uneempawu ezintsha okanye eziba mandundu emva kokuqala unyango nge-maraviroc, qiniseka ukuxelela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo kwakamsinya nje emva kokuba uyikhumbule, emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba kungaphantsi kweeyure ezingama-6 ngaphambi kwedosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IMaraviroc inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • ukukhwehlela, ukuphuma kwempumlo, okanye ezinye iimpawu zokubanda
  • intlungu yesihlunu okanye edibeneyo
  • iintlungu, ukutshisa, ukuba ndindisholo, okanye ukubetha ezandleni okanye ezinyaweni
  • isiyezi
  • urhudo
  • ukuqhina
  • ukuchama kabuhlungu okanye kunzima
  • izilonda ezimhlophe kunye / okanye iintlungu emlonyeni okanye kwi-esophagus (ityhubhu phakathi komlomo nesisu)
  • ubunzima bokulala okanye ukulala
  • lala uhamba, ulale uthetha, ulale yoyikekayo, okanye usebenze ebuthongweni bakho

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, okanye ezo zidweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

  • umqala obuhlungu, umkhuhlane, ukugodola, okanye ezinye iimpawu zosulelo
  • Intlungu yesifuba, uxinzelelo, okanye ukungonwabi
  • intlungu kwisandla esinye okanye zombini, umqolo, intamo, umhlathi, okanye isisu
  • ukuqhawukelwa ngumphefumlo
  • ukubila

IMaraviroc inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Lahla nasiphi na isisombululo somlomo esingasetyenziswanga kwiintsuku ezingama-60 emva kokuqala ukuvula ibhotile.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

  • utywala, intloko, okanye ukuphelelwa amandla xa uvuka ngokukhawuleza kwindawo yokulala

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • Ivenkile®
Ukuhlaziywa kokugqibela-01/15/2021

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