I-Tolvaptan (isodiyam ephantsi yegazi)

Umxholo

• Ngaphambi kokuthatha i-tolvaptan (iSamsca),
• I-Tolvaptan (iSamsca) inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Tolvaptan (iSamsca) inokubangela inqanaba lesodium egazini lakho ukuba lonyuke ngokukhawuleza. Oku kunokubangela i-osmotic demyelination syndrome (ODS; umonakalo omkhulu we-nerve onokubangelwa kukunyuka okukhawulezayo kumanqanaba e-sodium). Xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala, ukuba awunalondrition (umzimba awunazo izakhamzimba ezifunekayo kwimpilo entle), kwaye ukuba ukhe unesifo sesibindi okanye amanqanaba asezantsi kakhulu esodiyam egazini lakho .

Wena kunye nogqirha uya kuthatha amanyathelo athile okuzama ukukhusela i-ODS. Uya kuluqala unyango lwakho nge-tolvaptan (Samsca) esibhedlele ukuze ugqirha wakho abeke esweni ngokusondeleyo. Ukuba ugqirha wakho ukuxelela ukuba uqhubeke uthatha i-tolvaptan (Samsca) emva kokuba uphumile esibhedlele, akufuneki uyeke kwaye uqale unyango ngokwakho. Uya kudinga ukubuyela esibhedlele xa uqala kwakhona amayeza.

Uya kudinga ukusela amanzi nanini na xa unxaniwe ukunceda ukuthintela i-ODS ngexesha lonyango lwakho nge-tolvaptan (Samsca). Ugqirha wakho akazukuyalela i-tolvaptan (Samsca) ukuba awukwazi ukuziva unxaniwe. Kuya kufuneka ube namanzi okusela ngalo lonke ixesha ngexesha lonyango.

Ukuba unazo naziphi na kwezi mpawu zilandelayo ze-ODS, xelela ugqirha wakho kwangoko: kunzima ukuthetha, kunzima ukugwinya, uziva ukuba ukutya okanye iziselo ziyabambeka emqaleni wakho, ukozela, ukudideka, ukutshintsha kwemood, intshukumo yomzimba ekunzima ukuyilawula, ubuthathaka iingalo okanye imilenze, okanye ukuxhuzula.

Kuya kufuneka uyazi ukuba i-tolvaptan ikwakhona njengecwecwe (Jynarque) ukucothisa ukwanda kokusebenza kwezintso kubantu abadala abanesifo esithile sezintso esizuzwe njengelifa. Ukuba unesi sifo sezintso, akufuneki uthathe i-tolvaptan (Samsca). Ngenxa yomngcipheko weengxaki zesibindi nge-tolvaptan, i-Jynarque ifumaneka kuphela kwinkqubo ekhethekileyo yokuhambisa. Le monograph inika kuphela ulwazi malunga neepilisi ze-tolvaptan (iSamsca) zokunyanga amanqanaba asezantsi esodiyam egazini. Ukuba usebenzisa eli yeza ukuthoba ukwanda komsebenzi wezintso, funda i-monograph enesihloko esithi tolvaptan (isifo sezintso).

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-tolvaptan kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko wokuthatha i-tolvaptan (Samsca).

I-Tolvaptan (iSamsca) isetyenziselwa ukunyanga i-hyponatremia (amanqanaba asezantsi esodiyam egazini) kubantu abanesifo sentliziyo (imeko apho intliziyo ingakwazi ukumpompa igazi elaneleyo kuwo onke amalungu omzimba), isifo sehomoni ye-antidiuretic engafanelekanga (SIADH; imeko apho umzimba uvelisa ubuninzi bezinto ezithile zendalo ezibangela ukuba umzimba ugcine amanzi) okanye ezinye iimeko. I-Tolvaptan ikudidi lwamayeza abizwa ngokuba yi-vasopressin V₂ abachasi be-receptor. Isebenza ngokwandisa inani lamanzi akhululwe emzimbeni njengomchamo. Ukususa ulwelo emzimbeni kuyanceda ukonyusa inqanaba le-sodium egazini.

I-Tolvaptan (iSamsca) iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya kungekho ngaphezulu kweentsuku ezingama-30. Ekuqaleni konyango lwakho, uya kunikwa i-tolvaptan (iSamsca) ngexesha elimiselweyo esibhedlele. Ukuba uxelelwe ukuba uthathe i-tolvaptan (Samsca) ekhaya emva kokuba ukhutshiwe, kuya kufuneka uyithathe ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-tolvaptan (Samsca) ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho uya kukuqala ngedosi esezantsi ye-tolvaptan (iSamsca) kwaye ngokuthe ngcembe uyonyuse umthamo wakho, hayi rhoqo kunakuqala rhoqo kwiiyure ezingama-24.

Thetha nogqirha wakho malunga nento ekufuneka uyenzile emva kokuba uyekile ukuthatha i-tolvaptan (Samsca). Uya kudinga ukunciphisa umda kulwelo oselwayo, kwaye ugqirha wakho uya kukujonga ngononophelo ngeli xesha.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-tolvaptan (iSamsca),

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-tolvaptan (iSamsca, iJynarque), nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-tolvaptan. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha ii-antifungal ezithile ezinje nge ketoconazole (Nizoral) okanye itraconazole (Sporanox); i-clarithromycin (i-Biaxin); amayeza athile e-HIV afana ne-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), okanye saquinavir (Invirase); desmopressin (dDAVP, Stimate); nefazodone; okanye telithromycin (Ketek). Ugqirha wakho unokukuxelela ukuba ungathathi i-tolvaptan (Samsca) ukuba uthatha elinye okanye nangaphezulu la mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin, eLotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (Prinivil, Zestril, in Zestoretic), moexipr , perindopril, (quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), kunye ne-trandolapril (Tarka); , e-Hyzaar), e-olmesartan (eBenicar, kwi-Benicar HCT, e-Tribenzor), e-telmisartan (Micardis, e-Twynsta), nase-valsartan (e-Diovan, e-Prexxartan, e-Entresto, e-Exforge); i-aprepitant (Emend); i-barbiturates efana ne-phenobarbital; (ICarbatrol, i-Equetro, iTegretol); i-cyclosporine (Gengraf, Neoral, Sandimmune); desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin); diltiazem (Cardizem, Diltzac, Tiazac); i-diuretics (iipilisi zamanzi); i-erythromycin ( I-ERYC, i-Erythrocin, i-PCE); i-fluconazole (iDiflucan); phenytoin (Dilant ngaphakathi); izongezo zepotassium; irifabutin (Mycobutin); irifampin (Rimactane, Rifadin, eRifater, eRifamate); irifapentine (Priftin); kunye neverapamil (Calan, Verelan, eTarka). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-tolvaptan (Samsca), ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo okanye oceba ukuzithatha, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unesifo sezintso kwaye awuvelisi umchamo, ukuba uyagabha kakhulu okanye urhudo, okanye ukuba uphulukene nolwelo oluninzi emzimbeni wakho kwaye uziva unesiyezi okanye utyhafe. Ugqirha wakho uya kukuxelela ukuba ungathathi i-tolvaptan (Samsca). Ugqirha wakho ngekhe akhuphe i-tolvaptan (iSamsca) ukuba inqanaba lesodium kufuneka lonyuswe ngokukhawuleza okukhulu.
• xelela ugqirha wakho ukuba unayo okanye wakhe wanenqanaba eliphezulu le potassium egazini lakho.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-tolvaptan (Samsca), tsalela umnxeba ugqirha wakho.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Tolvaptan (iSamsca) inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• unxano
• umlomo owomileyo
• Ukuchama rhoqo
• ukuqhina

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• Ukuphelelwa ngumdla wokutya
• isicaphucaphu
• ukugabha
• ifiva
• ndiziva ndingaphilanga
• ukudinwa okungaqhelekanga okanye ubuthathaka
• ukurhawuzelela
• mthubi ulusu okanye amehlo
• umchamo omnyama
• iintlungu kwinxalenye ephezulu yesisu
• urhudo
• ukungakwazi ukusela ngesiqhelo
• isiyezi
• ukudinwa
• ukugabha okunegazi okanye okujongeka njengendawo yekofu
• enegazi okanye emnyama kunye nezitulo ezilindileyo
• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukudinwa
• urhwebo
• irhashalala

I-Tolvaptan (iSamsca) inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukuchama kakhulu
• ukunxanwa ngokugqithiseleyo
• isiyezi
• ukudinwa

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-tolvaptan (Samsca).

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• USamsca^®