Rilpivirine

Umxholo

• Ngaphambi kokuba uthathe i-rilpivirine,
• I-Rilpivirine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, tsalela ugqirha wakho kwangoko:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu yeka ukuthatha i-rilpivirine kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

I-Rilpivirine isetyenziswa kunye namanye amayeza ukunyanga intsholongwane 1 (HIV-1) kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu abanobunzima obungama-77 lb (35 kg) nabangazange bafumane unyango lwe-antiretroviral ngaphambili. Isetyenziswa kunye ne-cabotegravir (Vocabria) njengonyango lwexeshana losulelo lwe-HIV-1 kubantu abadala abathile. I-Rilpivirine ikwiklasi yamayeza abizwa ngokuba yi-non-nucleoside reverse transcriptase inhibitors (NNRTIs). Isebenza ngokunciphisa inani le-HIV egazini. Nangona i-rilpivirine ingayinyangi i-HIV, inokuwanciphisa amathuba akho okuba ne-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezinje ngezifo ezinzulu okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokuhambisa (ukusasaza) intsholongwane kagawulayo kwabanye abantu.

I-Rilpivirine iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa ngokutya (hayi nje isiselo seprotein) kanye ngemini. Xa i-rilpivirine ithathwa kunye ne-cabotegravir, ihlala ithathwa kube kanye yonke imihla kunye nokutya. Thatha i-rilpivirine yodwa okanye kunye nekhabotegravir ngexesha elifanayo yonke imihla. I-Rilpivirine ithathwa kunye ne-cabotegravir malunga nenyanga enye (ubuncinci iintsuku ezingama-28) ngaphambi kokuqala unyango ngeendlela ezisebenza ngenaliti zala mayeza okanye ukuya kuthi ga kwiinyanga ezi-2 ukuba ishedyuli yonyango yenaliti ilahlekile ngaphezulu kweentsuku ezisixhenxe. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-rilpivirine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

I-Rilpivirine ilawula i-HIV kodwa ayiyinyangi. Qhubeka nokuthatha i-rilpivirine nokuba uziva uphilile. Sukuyeka ukuthatha i-rilpivirine ngaphandle kokuthetha nogqirha wakho. Xa unikezelo lwakho lwe-rilpivirine luqala ukuba phantsi, fumana ngakumbi kugqirha wakho okanye kwikhemesti. Ukuba uphosa idosi okanye uyeke ukuthatha i-rilpivirine, imeko yakho kunokuba nzima ukunyanga.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-rilpivirine,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-rilpivirine, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-rilpivirine. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha i-dexamethasone (i-Decadron); amayeza okubanjwa kubandakanya i-carbamazepine (Carbatrol, Epitol, Euetro, Tegretol, Teril), oxcarbazepine (Trileptal), phenobarbital (Luminal), okanye phenytoin (Dilantin, Phenytek); Iiproton pump inhibitors kubandakanya i-dexlansoprazole (Dexilant), esomeprazole (Nexium, Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), okanye rabeprazole (Aciphex); irifampin (Rifater, Rifamate, Rimactane, Rifadin); irifapentine (Priftin); kunye neSt. Ugqirha wakho uya kukuxelela ukuba ungathathi i-rilpivirine ukuba uthatha elinye okanye ngaphezulu kwala mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza okubola, kubandakanya i-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); amiodarone (Nexterone, iPacerone); anagrelide (Agrylin); chloroquine; chlorpromazine; ililostazol; ciprofloxacin (Cipro); ikitalopram (uCelexa); i-clarithromycin (i-Biaxin); iDisopyramide (iNorpace); dofetilide (iTikosyn); I-donepezil (iAricept); erythromycin (E-Mycin, Eryc, Ery-Tab, PCE, Pediazole); i-flecainide (iTambocor); haloperidol (iHaldol); ibutilide (iCorvert); levofloxacin; imethadone (iDolophine); moxifloxacin (Velox); i-nelfinavir (iViracept); I-ondansetron (iZuplenz, iZofran); amanye amayeza e-NNRTI anyanga i-HIV / AIDS; ipentamidine (NebuPent, Pentam); ipimozide (Orap); ukuvelisa; quinidine (kwiNuedexta); irifabutin (Mycobutin); i-sotalol (iBetapace, iSorine, iSotylize); telithromycin (Ketek); kunye ne-thioridazine. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-rilpivirine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha ii-antacids ezine-calcium, i-magnesium, okanye i-aluminium (Maalox, Mylanta, Tums, others), zithathe ubuncinci iiyure ezi-2 ngaphambi okanye kwiiyure ezi-4 emva kwe-rilpivirine.
• ukuba uthatha amayeza okugaya isisu, ukutsha, okanye izilonda ezinje nge-cimetidine (Tagamet), i-famotidine (Pepcid), i-nizatidine (i-Axid), okanye i-ranitidine (i-Zantac), thatha ubuncinci iiyure ezili-12 ngaphambi okanye ubuncinci iiyure ezi-4 emva kwe-rilpivirine .
• ukuba uthatha i-didanosine (Videx), yithathe ubuncinci iiyure ezi-2 ngaphambi okanye ubuncinci iiyure ezi-4 emva kwe-rilpivirine.
• xelela ugqirha wakho ukuba ukhe wanokudakumba okanye unesifo sengqondo, isifo sesibindi, kubandakanya ihepatitis B okanye C, okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ukhulelwe ngelixa uthatha i-rilpivirine, tsalela ugqirha wakho. Tshela ugqirha wakho ukuba uncelisa. Akufuneki uncancise xa wosulelwe yi-HIV okanye ukuba uthatha i-rilpivirine.
• Kuya kufuneka uyazi ukuba amanqatha omzimba wakho anokunyuka okanye ahambele kwiindawo ezahlukeneyo zomzimba wakho ezinje ngamabele akho, umqolo ongasentla nentamo, okanye ujikeleze umbindi womzimba wakho. Ukuphulukana namafutha emilenzeni, ezingalweni nasebusweni nako kunokwenzeka.
• Kuya kufuneka uyazi ukuba i-rilpivirine inokubangela utshintsho kwiingcinga zakho, indlela oziphatha ngayo, okanye impilo yengqondo. Fowunela ugqirha ngoko nangoko xa uvelisa ezi mpawu zilandelayo ngelixa uthatha i-rilpivirine: uxinzelelo olutsha okanye olubi uziva ulusizi, ungenathemba, uxhalabile, okanye ungonwabanga; okanye ucinga ngokuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo. Qiniseka ukuba usapho lwakho luyazazi ukuba zeziphi iimpawu ezinokubanzima ukuze bakwazi ukubiza ugqirha wakho ukuba awukwazi ukuzifunela unyango ngokwakho.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho okanye zibangele ezinye iimeko zenzeke. Oku kunokubangela ukuba ukhule iimpawu zolo sulelo okanye iimeko. Ukuba uneempawu ezintsha okanye eziba mandundu emva kokuqala unyango nge-rilpivirine, qiniseka ukuxelela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule, ngokutya. Nangona kunjalo, ukuba ngaphezulu kweeyure ezili-12 ukusukela kwidosi yakho yokugqibela, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Rilpivirine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubunzima bokulala okanye ukulala
• intloko ebuhlungu
• isicaphucaphu
• ukugabha
• isiyezi
• intlungu zesisu
• ukozela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, okanye ezo zidweliswe kwicandelo LOKUKHUSELWA OKUQHELEKILEYO, tsalela ugqirha wakho kwangoko:

• irhashalala
• mthubi ulusu okanye amehlo, iintlungu kwicala lasekunene lesisu, isicaphucaphu, ukugabha, izitulo ezikhanyayo, umchamo omnyama

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu yeka ukuthatha i-rilpivirine kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala ihamba ne umkhuhlane, ukudumba kobuso, imilebe, umlomo, ulwimi, okanye umqala, amablister, ingxaki yokuphefumla okanye ukugwinya, izilonda zomlomo, ubomvu okanye ukudumba kwamehlo (conjunctivitis), iintlungu kwicala lasekunene lesisu (esiswini), okanye umchamo omnyama ngombala

I-Rilpivirine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho kwi-rilpivirine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Gcina unikezelo lwe-rilpivirine ngesandla. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Edurant^®
• UJuluca^® (njengemveliso yokudibanisa equlathe i-dolutegravir, rilpivirine)