IPonatinib

Umxholo

• Ngaphambi kokuba uthathe iponatinib,
• I-Ponatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, yeka ukuthatha iponatinib kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Ponatinib inokubangela ukuba igazi lisongele okanye lisongele ubomi emilenzeni okanye emiphungeni, ekuhlaselweni yintliziyo, okanye kwimivumbo. Tshela ugqirha wakho ukuba ukhe wakha unegazi kwimiphunga okanye emilenzeni; ukubetha; igazi elonyukayo; hyperlipidemia (amanqanaba aphezulu e-cholesterol egazini lakho); ukubetha kwentliziyo okukhawulezayo, okukhawulezayo, okanye okungaqhelekanga; isifo semithambo yegazi (ukunciphisa imithambo yegazi ezinyaweni, emilenzeni, okanye ezingalweni kubangela ukuba ndindisholo, iintlungu, okanye ukubanda kuloo ndawo yomzimba); isifo sentliziyo; okanye isifo sentliziyo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: iintlungu zesifuba; ukuqhawukelwa ngumphefumlo; isiyezi okanye ukuphelelwa ngamandla; ukudideka ngesiquphe okanye ingxaki yokuthetha okanye ukuqonda; ukuphazamiseka ngesiquphe okanye ubuthathaka bobuso, ingalo, okanye umlenze kwelinye icala lomzimba; intloko ebukhali ngesiquphe; umlenze, ingalo, umqolo, intamo, okanye iintlungu zomhlathi; imvakalelo ubushushu emlenzeni esezantsi; okanye ukudumba kweenyawo, amaqatha okanye imilenze esezantsi.

I-Ponatinib inokubangela ukusilela kwentliziyo okusongela ubomi (imeko apho intliziyo ingakwaziyo ukupompa igazi elaneleyo kwamanye amalungu omzimba) kunye ne-arrhythmias (izingqisho zentliziyo engaqhelekanga). Tshela ugqirha wakho ukuba ukhe wanengxaki yentliziyo, kubandakanya ukungaphumeleli kwentliziyo, ukongezwa kweQT (isingqisho sentliziyo esingaqhelekanga esinokukhokelela ekuphelelweni lithemba, ekulahlekelweni sisazela, ukuxhuzula, okanye ukufa ngesiquphe); okanye ukubetha kwentliziyo okucothayo, okukhawulezayo, okanye okungaqhelekanga. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngokukhawuleza: ukuphefumla kancinci; iintlungu zesifuba; ukukhawuleza, ukungahambi kakuhle, okanye ukubetha kwentliziyo; isiyezi; okanye isiqaqa.

I-Ponatinib inokubangela umonakalo omkhulu okanye osongela ubomi kwisibindi. Tshela ugqirha wakho ukuba ukhe unesifo sesibindi okanye uneengxaki kwisibindi sakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukurhawuzelela, amehlo atyheli okanye ulusu, umchamo omnyama, okanye iintlungu okanye ukungonwabi kwindawo elungileyo yesisu.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyala iimvavanyo ezithile ngaphambi kokuba uqale kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-ponatinib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ponatinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Ponatinib isetyenziselwa ukunyanga iintlobo ezithile ze-myeloid leukemia engapheliyo (i-CML; uhlobo lomhlaza weeseli ezimhlophe zegazi), kubandakanya unyango kubantu abangasenakuxhamla kwamanye amayeza e-CML okanye abangakwaziyo ukuthatha la mayeza ngenxa yeziphumo ebezingalindelekanga. I-Ponatinib ikwasetyenziselwa ukunyanga iintlobo ezithile ze-acety lymphoblastic leukemia (ZONKE; uhlobo lomhlaza weeseli ezimhlophe zegazi) kubantu abangasenakuxhamla kwamanye amayeza e-leukemia okanye abangakwaziyo ukuthatha la mayeza ngenxa yeziphumo ebezingalindelekanga. IPonatinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

I-Ponatinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya. Thatha i-ponatinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ponatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokufuna ukulibazisa unyango lwakho, uhlengahlengise idosi yakho, okanye uyeke ngokusisigxina unyango lwakho lweponatinib ngokuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-ponatinib nokuba uziva uphilile. Ungayeki ukuthatha iponatinib ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe iponatinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-ponatinib, nawaphi na amanye amayeza, i-lactose, okanye naziphi na izithako kwiipilisi ze-ponatinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ketoconazole (Nizoral); amayeza okunciphisa isisu esiswini, njenge-lansoprazole (Prevacid); kunye nerifampin (Rifadin, Rimactane, eRifamate, eRifater). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-ponatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe wanengxaki yokopha; isifo seswekile; i-pancreatitis (ukudumba kwepancreas, idlala elisesiswini elivelisa izinto ukunceda ukwetyisa); okanye ukuba awunyamezeli i-lactose (ukungakwazi ukwetyisa iimveliso zobisi). Kwakhona xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala.
• Kuya kufuneka uyazi ukuba i-ponatinib inokunciphisa ukuzala kwabasetyhini. Nangona kunjalo, awufanelanga ukucinga ukuba wena okanye iqabane lakho aninakukhulelwa. Tshela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho nge-ponatinib kunye nakwiiveki ezi-3 emva kokuba uyekile ukuthatha amayeza. Thetha nogqirha wakho malunga neentlobo zolawulo lokuzalwa oluza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-ponatinib, biza ugqirha wakho ngokukhawuleza. I-Ponatinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-ponatinib kunye neentsuku ezingama-6 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-ponatinib. Ukuba ucwangciselwe ukuba utyando, ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-ponatinib okungenani iintsuku ezisi-7 ngaphambi kotyando okanye inkqubo. Ugqirha wakho uya kukuxelela ukuba uqale nini ukuthatha i-ponatinib kwakhona emva kotyando lwakho.
• Kuya kufuneka uyazi ukuba uxinzelelo lwegazi lwakho lunokunyuka ngexesha lonyango lwakho ngeponatinib. Ugqirha wakho uya kuthi abeke esweni uxinzelelo lwegazi ngexesha lonyango lwakho.

Musa ukutya isixa esikhulu segrapefruit okanye usele ijusi yeziqhamo zomdiliya ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ponatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• irhashalala
• isikhumba esomileyo
• urhudo
• ukuqhina
• ukulahleka kweenwele
• amabala amhlophe okanye izilonda emilebeni okanye emlonyeni nasemqaleni
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukukhohlela
• ubunzima bokulala okanye ukulala
• umqolo, ithambo, ilungu, ilungu lomzimba, okanye iintlungu zemisipha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, yeka ukuthatha iponatinib kwaye ubize ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukugruzuka okanye ukopha okungaqhelekanga
• enegazi okanye emnyama, ilindle
• igazi kumchamo
• ukugabha okunegazi
• ukopha okungaqhelekanga kwilungu lobufazi okanye ukuba nzima kunokuba kuphuma gazi njengesiqhelo
• ukugabha okujongeka njengendawo yekofu
• ukopha rhoqo
• ukhohlela igazi
• bomile, bomvu, buhlungu, okanye bacaphuka
• uvakalelo ekukhanyeni
• umbono ophazamisayo, i-float, umbono ophindwe kabini, okanye olunye utshintsho lombono
• amanxeba angapholiyo
• umkhuhlane, umqala obuhlungu, ingqele, okanye ezinye iimpawu zosulelo
• utshintsho incasa; ubuthathaka bemisipha; ukuxhoma iinkophe okanye inxalenye yobuso; ukurhawuzelela, ukutshisa, iintlungu, okanye ukulahleka kwemvakalelo ezandleni nasezinyaweni
• intloko, ukuxhuzula, ukudideka, iingxaki zokucinga, okanye utshintsho okanye ukulahleka kombono
• ukuncipha kokuchama
• ukudinwa kakhulu okanye ubuthathaka
• ukutyeba kwakho
• ukudumba kobuso bakho, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• intlungu, ukuvuvukala, okanye ukuthamba kwisisu (indawo yesisu)
• isicaphucaphu
• ukugabha
• iintlungu eziqhubekayo eziqala kwindawo yesisu kodwa zinokusasazeka ngasemva

I-Ponatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• umkhuhlane, umqala obuhlungu, ukugodola kunye neminye imiqondiso yosulelo
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• ukudinwa
• iintlungu zesifuba

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Iclusig^®