ICabozantinib (umhlaza wesibindi kunye nezintso)

Umxholo

• Ngaphambi kokuba uthathe i-cabozantinib (Cabometyx),
• ICabozantinib (Cabometyx) inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Cabozantinib (Cabometyx) isetyenziselwa ukunyanga i-renal cell carcinoma (RCC; uhlobo lomhlaza oqala kwiiseli zezintso). Ikwasetyenziswa kunye ne-nivolumab (i-Opdivo) ukunyanga i-RCC ephambili kwizigulana ezingekafumani nyango lwe-RCC. I-Cabozantinib (Cabometyx) ikwasetyenziselwa ukunyanga i-hepatocellular carcinoma (HCC; uhlobo lomhlaza wesibindi) kubantu ababephathwa ngaphambili nge-sorafenib (Nexafar). ICabozantinib (Cabometyx) ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

ICabozantinib ikwafumaneka njengephilisi (iCometriq) ukunyanga uhlobo oluthile lomhlaza wedlala lengqula. Le monograph inika kuphela ulwazi malunga neetafile ze-cabozantinib (Cabometyx) ye-RCC ephezulu okanye ye-HCC. Ukuba usebenzisa eli yeza lomhlaza wedlala lengqula, funda i-monograph enesihloko esithi cabozantinib (umhlaza wedlala lengqula).

ICabozantinib (Cabometyx) iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kwisisu esingenanto, ubuncinci iyure enye ngaphambi kunye neeyure ezi-2 emva kokutya. Thatha i-cabozantinib (Cabometyx) malunga nexesha elifanayo yonke imihla. Ubude bonyango lwakho buxhomekeke kwindlela ophendula ngayo emzimbeni wakho kunyango nakwiziphumo ebezingalindelekanga ohlangabezana nazo. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-cabozantinib (Cabometyx) ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gwinya amacwecwe apheleleyo ngeglasi epheleleyo (ii-ounces eziyi-8, i-240 mL) yamanzi. Musa ukwahlula, ukuhlafuna, okanye ukuchoboza.

Ugqirha wakho unokunciphisa idosi yakho ye-cabozantinib (Cabometyx) okanye ngokusisigxina okanye okwexeshana uyeke unyango lwakho xa uneziphumo ebezingalindelekanga ezibi. Qiniseka ukuba uthethe nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho nge-cabozantinib (Cabometyx).

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-cabozantinib (Cabometyx),

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-cabozantinib (i-Cabometyx, i-Cometriq), nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-cabozantinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, othabathayo okanye oceba ukuthatha. Qiniseka ukuba ukhankanya oku kulandelayo: boceprevir (Victrelis), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), clarithromycin (Biaxin, e-Prevpac), conivaptan (Vaprisol), indinavir (Crixivan), itraconazole ( ), ketoconazole, nefazodone, nelfinavir (Viracept), phenobarbital, phenytoin (Dilantin, Phenytek), posaconazole (Noxafil), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifamate, Rifater, Rifater) , e-Kaletra), saquinavir (Invirase), telithromycin (Ketek), kunye ne-voriconazole (Vfend). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana necabozantinib (Cabometyx), ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ngaba ubusandula ukopha ngokungaqhelekanga njengokukhwehlela igazi, ukugabha igazi, okanye izitulo ezilindileyo ezinegazi okanye ezimnyama, ukuba unenxeba elivulekileyo okanye elipholileyo, okanye ukuba unayo okanye ukhe wanalo uxinzelelo oluphezulu lwegazi, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango nge-cabozantinib. Akufanele ukhulelwe ngexesha lonyango lwakho kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-cabozantinib (Cabometyx), tsalela ugqirha ngokukhawuleza. ICabozantinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Ugqirha wakho unokukuxelela ukuba ungancancisi ngexesha lonyango lwakho kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nomngcipheko wokuthatha i-cabozantinib (Cabometyx).
• ukuba uyenziwa utyando xelela ugqirha ukuba uthatha i-cabozantinib (Cabometyx). Ugqirha wakho uyakukuxelela ukuba uyeke ukuthatha i-cabozantinib (Cabometyx) ubuncinci kwiintsuku ezingama-21 ngaphambi kotyando okanye inkqubo yakho, kwaye uya kukuxelela xa kufuneka uqale ngokuthatha amayeza kwakhona.
• Kuya kufuneka uyazi ukuba i-cabozantinib (Cabometyx) inokubangela iingxaki ezinzulu ngomhlathi wakho. Ugqirha wamazinyo kufuneka ahlolisise amazinyo akho ngaphambi kokuba uqale ukuthatha i-cabozantinib kwaye rhoqo ngexesha lonyango lwakho. Qiniseka ukuba uhlamba amazinyo kwaye ucoce umlomo ngokufanelekileyo ngelixa uthatha i-cabozantinib (Cabometyx). Thetha nogqirha wakho ngaphambi kokuba ufumane unyango lwamazinyo ngelixa uthatha eli yeza. Ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-cabozantinib ubuncinci kwiintsuku ezingama-21 ngaphambi kotyando lwamazinyo.
• Kuya kufuneka uyazi ukuba uxinzelelo lwegazi lwakho lunokunyuka ngexesha lonyango lwakho kunye necabozantinib. Ugqirha wakho uya kuthi abeke esweni uxinzelelo lwegazi ngaphambi nangexesha lonyango lwakho.

Musa ukusela ijusi yegrapefruit okanye utye iidiliya okanye nantoni na yokutya okanye izongezo eziqukethe iidiliya okanye ijusi yegrapefruit ngelixa uthatha eliyeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 kude kube yidosi elandelayo ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ICabozantinib (Cabometyx) inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• isicaphucaphu
• ukugabha
• utshintsho kwisakhono sokungcamla ukutya
• ubomvu, ukudumba, izilonda, okanye iintlungu emlonyeni wakho
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukudinwa kakhulu okanye ubuthathaka
• ulusu oluthuthu
• isikhumba esomileyo
• Ukudumba kwezihlunu
• iintlungu kumalungu, iingalo, okanye imilenze
• Ukutshintsha kwelizwi okanye ukungxola
• ukuphola kwenxeba

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• Intlungu yesifuba, uxinzelelo, okanye ukuqina
• ukukhohlela igazi okanye amahlwili egazi
• ukugabha okunento enegazi okanye okufana nekofu
• ukuphuma kwegazi okunzima kunesiqhelo
• obomvu okanye omnyama, isitulo sokulinda
• urhudo
• ukopha okungaqhelekanga okanye okunzima okanye ukugruzuka
• indawo yesisu ethambileyo okanye ebuhlungu
• kushushu, kubomvu, kudumbile, okanye yingalo ethambileyo okanye imilenze
• ukudumba ujikeleze amehlo, iingalo, izandla, imilenze, iinyawo, okanye amaqatha
• umchamo wegwebu
• ukuphefumla kancinci okanye ukukhohlela
• ngequbuliso intloko
• intloko elula okanye etyhafayo
• ukuxhuzula
• Ukuba ndindisholo okanye ukuba buthathaka kobuso, ingalo, okanye umlenze kwelinye icala lomzimba wakho
• ukuhamba ngesiquphe
• iingxaki zombono ngesiquphe
• ukudideka
• ubunzima ngesiquphe bokucinga okanye ukuthetha ngokucacileyo
• ubunzima ngequbuliso ngokulingana okanye ngokulungelelanisa
• isiyezi
• ukubila ngaphezulu kwesiqhelo
• iintlungu zomhlathi
• Lizinyo
• ukukhululeka kwamazinyo
• Iintsini ezidumbileyo okanye ezibuhlungu
• irhashalala
• ubomvu, iintlungu, ukudumba, okanye ukudumba ezintendeni okanye ematheni
• ukudinwa kakhulu, ukuba nesiyezi, ukuphelelwa ngamandla, ukuba buthathaka, isicaphucaphu, okanye ukugabha
• ukuba tyheli kolusu okanye kwamehlo, ukudinwa kakhulu, ukopha okanye ukugruzuka ngokulula, isicaphucaphu okanye ukugabha, iintlungu zesisu esisemacaleni, umchamo onombala omnyama, ukuncipha kokutya

ICabozantinib (Cabometyx) inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukulahleka kwememori
• ukudideka
• ukuhla ukusinda

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-cabozantinib (Cabometyx).

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ikhabhathi^®