Inaliti yeBuprenorphine

Umxholo

• Ngaphambi kokufumana inaliti ye-buprenorphine,
• I-Buprenorphine eyandisiweyo yokukhutshwa kwenaliti inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

Inaliti yokukhutshwa kwe-Buprenorphine eyandisiweyo ifumaneka kuphela kwinkqubo ekhethekileyo yokuhambisa ebizwa ngokuba yi-Sublocade REMS. Ugqirha wakho kunye nekhemesti kufuneka babhalise kule nkqubo ngaphambi kokuba ufumane inaliti ye-buprenorphine. Buza ugqirha wakho ngolwazi oluthe kratya malunga nale nkqubo kunye nendlela oza kuwafumana ngayo amayeza akho.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unoku-odola uvavanyo oluthile ngaphambi kunye nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-buprenorphine injection-release release.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seMithi) xa uqala unyango ngenaliti yokukhupha eyandisiweyo ye-buprenorphine kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

I-Buprenorphine eyandisiweyo yokukhutshwa kwenaliti isetyenziselwa ukunyanga ukuxhomekeka kwe-opioid (iziyobisi ze-opioid, kubandakanya i-heroin kunye ne-narcotic painkillers) kubantu abafumene i-buccal okanye i-buprenorphine engaphantsi kweentsuku ezisi-7. I-Buprenorphine eyandisiweyo yokukhutshwa kwenaliti ikwiklasi yamayeza abizwa ngokuba yi-opiate agonists. Isebenza ukukhusela iimpawu zokurhoxa xa umntu eyeka ukuthatha iziyobisi ze-opioid ngokuvelisa iziphumo ezifanayo kula machiza.

I-Buprenorphine eyandisiweyo-yokukhululwa (esebenza ixesha elide) inaliti iza njengesisombululo (ulwelo) sokutofwa (ngaphantsi nje kwesikhumba) ngumboneleli wezempilo kwindawo yesisu. Ihlala inikwa kube kanye ngenyanga kunye neentsuku ezingama-26 ubuncinci phakathi kweedosi. Inaliti nganye ye-buprenorphine ikhupha kancinci ichiza emzimbeni wakho ngaphezulu kwenyanga.

Emva kokuba ufumene idosi yenaliti yokukhupha i-buprenorphine eyandisiweyo, unokuqaphela isigaxa kwindawo yenaliti kangangeeveki ezininzi, kodwa kufuneka sinciphise ubungakanani ngokuhamba kwexesha. Musa ukurabha okanye uhlikihle indawo yenaliti. Qiniseka ukuba ibhanti okanye ibhanti yakho ayifaki xinzelelo kwindawo apho lalifakwe khona iyeza.

Ugqirha wakho unokunyusa okanye anciphise idosi yakho ngokuxhomekeke ekubeni lisebenza kanjani na iyeza lakho, kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho ngenaliti yokukhutshwa kwe-buprenorphine.

Ukuba ukukhutshwa kwe-buprenorphine eyandisiweyo kuya kuyekiswa, ugqirha wakho uya kunciphisa idosi yakho ngokuthe ngcembe. Unokuba neempawu zokurhoxa kubandakanya ukungazinzi, amehlo aneenyembezi, ukubila, ukugodola, ukwanda kwabafundi (izangqa ezimnyama phakathi kwamehlo), ukuba nochuku, ixhala, umqolo obuhlungu, ubuthathaka, isisu, ubunzima bokulala okanye ukuhlala ulele, isicaphucaphu, ukuphelelwa ngumdla, ukugabha, urhudo, ukuphefumla ngokukhawuleza, okanye ukubetha kwentliziyo okukhawulezayo. Ezi mpawu zokurhoxa zinokwenzeka kwinyanga e-1 okanye ngaphezulu emva kwedosi yakho yokugqibela yenaliti yokukhululwa kwe-buprenorphine.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-buprenorphine,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-buprenorphine, nawaphi na amanye amayeza, okanye naziphi na izithako kwiinaliti ze-buprenorphine. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: antihistamines; i-benzodiazepines ezinje ngealprazolam (Xanax), chlordiazepoxide (Librium, eLibrax), clonazepam (Klonopin), diazepam (Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), carbamazepine (Carbatrol, Tegretol, Teril, nabanye); umchamo ('iipilisi zamanzi'); erythromycin (EES, Eryc, PCE, nabanye); Amayeza e-HIV afana ne-atazanavir (Reyataz, e-Evotaz), delavirdine (Rescriptor), efavirenz (Sustiva, e-Atripla), etravirine (Intelence), indinavir (Crixivan), nevirapine (Viramune), ritonavir (Norvir, e Kaletra), nase saquinavir (Inkuthazo); amayeza athile okubetha kwentliziyo okungaqhelekanga kubandakanya i-amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), procainamide (Procanbid), quinidine (eNuedexta), kunye ne-sotalol (Betapace, Betapace AF, Sorine); amayeza e-glaucoma, isifo sengqondo, isifo sokuhamba, isifo sika-Parkinson, izilonda, okanye iingxaki zomchamo; ketoconazole, amanye amayeza eentlungu; amayeza e-migraine iintloko ezinje nge-almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, eTreximet), kunye ne-zolmitriptan (iZomig); izihlunu ezonwabisayo; phenobarbital; phenytoin (iDilantin, iPhenytek); irifampin (Rifadin, Rimactane); ukuthomalalisa; iipilisi zokulala; I-5HT3 i-serotonin blockers efana ne-alosetron (Lotronex), i-dolasetron (i-Anzemet), i-granisetron (i-Kytril), i-ondansetron (i-Zofran, i-Zuplenz), okanye i-palonosetron (i-Aloxi); i-inhibitors ekhethiweyo ye-serotonin-reuptake inhibitors enjenge citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), kunye sertraline (Zoloft); i-serotonin kunye ne-norepinephrine reuptake inhibitors enjenge-duloxetine (iCymbalta), i-desvenlafaxine (i-Khedezla, i-Pristiq), i-milnacipran (i-Savella), kunye ne-venlafaxine (i-Effexor); i-tramadol; izinto zokuthomalalisa; ithenda okanye i-tricyclic antidepressants (’mood elevators’) ezinje ngeamitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactiline), kunye neTrimipramine. Xelela ugqirha wakho okanye usokhemesti ukuba uthatha okanye ufumana i-monoamine oxidase (MAO) inhibitors okanye ukuba uyekile ukuzithatha kwezi veki zimbini zidlulileyo: isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil) , selegiline (Eldepryl, Emsam, Zelapar), okanye tranylcypromine (iParnate). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-buprenorphine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba wena okanye ilungu losapho uyasela okanye wakha wasela izixa ezikhulu zotywala okanye wakha wanesifo se-QT (imeko eyonyusa umngcipheko wokuba nesifo sentliziyo esingaqhelekanga esinokubangela ukulahleka kwengqondo okanye ukufa ngesiquphe). Kwakhona, xelela ugqirha wakho ukuba unayo okanye wakhe wanamaqondo asezantsi e-potassium okanye yemagniziyam egazini; ukumelwa yintliziyo; ukubetha kwentliziyo kancinci okanye okungaqhelekanga; isifo esinganyangekiyo semiphunga (COPD; iqela lezifo ezichaphazela imiphunga kunye neendlela zomoya); nezinye izifo zemiphunga; ukwenzakala entloko; ithumba lobuchopho; nayiphi na imeko eyonyusa inani loxinzelelo kwingqondo yakho; iingxaki ze-adrenal ezifana nesifo se-Addison (imeko apho i-adrenal gland ivelisa i-hormone encinci kuneqhelekileyo); i-benign prostatic hypertrophy (BPH, ukwandisa i-prostate gland); ubunzima bokuchama; ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angabikho); igophe lomqolo elenza kubenzima ukuphefumla; okanye i-thyroid, i-gallbladder, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ufumana i-buprenorphine eyandisiweyo-yokukhupha inaliti rhoqo ngexesha lokukhulelwa kwakho, umntwana wakho unokuba neempawu ezisongela ubomi emva kokuzalwa. Xelela ugqirha wosana lwakho ngoko nangoko ukuba umntwana wakho unazo naziphi na kwezi mpawu zilandelayo: ukucaphuka, ukuxhalaba, ukulala ngendlela engaqhelekanga, ukukhala okuphezulu, ukungcangcazela okungalawulekiyo kwenxalenye yomzimba, ukugabha, urhudo, okanye ukusilela ukutyeba.
• xelela ugqirha wakho ukuba uncelisa. Xelela ugqirha womntwana wakho ngoko nangoko ukuba umntwana wakho ulele ngaphezu kwesiqhelo okanye unengxaki yokuphefumla ngelixa ufumana eli yeza.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga nomngcipheko wokusebenzisa inaliti yokukhululwa kwe-buprenorphine.
• ukuba uyenziwa utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana inaliti yokukhululwa kwe-buprenorphine.
• Kuya kufuneka uyazi ukuba i-buprenorphine eyandisiweyo-yokukhupha inaliti inokukwenza wozele. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• akufuneki usele utywala okanye usebenzise iziyobisi zasesitalatweni ngexesha lonyango lwakho. Ukusela utywala, ukuthatha amayeza kagqirha okanye ongabhalisiyo aqukethe utywala, okanye ukusebenzisa iziyobisi ezitalatweni ngexesha lonyango lwakho ngenaliti ye-buprenorphine yonyusa umngcipheko wokuba uza kuba neengxaki zokuphefumla ezinzulu nezisongela ubomi.
• Kuya kufuneka uyazi ukuba i-buprenorphine inokubangela ukuba ube nesiyezi, ukuba nentloko elula, kunye nokuphelelwa ngamandla xa usukuma ngokukhawuleza kwindawo oxokileyo kuyo. Ukuthintela le ngxaki, phuma kancinci ebhedini, uphumle iinyawo zakho phantsi imizuzu embalwa ngaphambi kokuba ume.
• Kuya kufuneka uyazi ukuba i-buprenorphine inokubangela ukuqhina. Thetha nogqirha wakho malunga nokutshintsha indlela otya ngayo okanye ukusebenzisa amanye amayeza ukuthintela okanye ukunyanga ukuqhina ngelixa usebenzisa inaliti ye-buprenorphine.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uyaphoswa yidosi ye-buprenorphine eyandisiweyo yokukhutshwa kwenaliti, kuya kufuneka ubize ugqirha wakho ukuba afumane idosi ngokukhawuleza. Idosi yakho elandelayo kufuneka inikwe ubuncinci kwiintsuku ezingama-26 kamva.

I-Buprenorphine eyandisiweyo yokukhutshwa kwenaliti inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• intloko ebuhlungu
• ukudinwa
• iintlungu, ukurhawuzelela, ukudumba, ukungonwabi, ukuba bomvu, ukutyumka, okanye amaqhuma kwindawo yenaliti

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ubunzima bokuphefumla
• Ukuphazamiseka, ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angekhoyo), umkhuhlane, ukubila, ukudideka, ukubetha kwentliziyo okukhawulezayo, ukungcangcazela, intetho edikidiki, ukuqina kwemisipha okanye ukujijeka, ukulahleka kokudibana, isicaphucaphu, ukugabha, okanye urhudo
• isicaphucaphu, ukugabha, ukungabi namdla wokutya, ukuba buthathaka okanye isiyezi
• ukungakwazi ukufumana okanye ukugcina ulwakhiwo
• ukuya exesheni ngokungaqhelekanga
• ukunciphisa umnqweno wesondo
• irhashalala
• urhwebo
• ukurhawuzelela
• intetho engacacanga
• ukungaboni kakuhle
• utshintsho kwintliziyo
• iintlungu kwinxalenye ephezulu yesisu
• mthubi ulusu okanye amehlo
• umchamo omnyama-mnyama
• izitulo ezikhanyayo

I-Buprenorphine eyandisiweyo yokukhutshwa kwenaliti inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Tsalela umnxeba woncedo lolawulo lweetyhefu ku-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• Ukunciphisa okanye ukwandisa abafundi (izangqa ezimnyama embindini wamehlo)
• ucothisile okanye kunzima ukuphefumla
• ukulala kakhulu okanye ukozela
• isiqaqa (ukulahleka kwengqondo ixesha elithile)
• ukubetha kwentliziyo kancinci

Ngaphambi kokuba uvavanywe elebhu (ngakumbi ezo zibandakanya imethylene eluhlaza okwesibhakabhaka), xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba usebenzisa inaliti ye-buprenorphine.

Kwimeko yongxamiseko, ilungu losapho okanye umntu okhathalelayo kufuneka axelele abasebenzi bezonyango olungxamisekileyo ukuba uxhomekeke emzimbeni kwi-opioid kwaye ufumana unyango ngenaliti yokukhupha eyandisiweyo ye-buprenorphine.

I-Buprenorphine eyandisiweyo-yokukhupha inaliti yinto elawulwayo. Qiniseka ukuba ucwangcisa ixesha lokuqeshwa nogqirha wakho rhoqo ukufumana inaliti yakho. Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Inkqutyana^®