Umbhali: Gregory Harris
Umhla Wokudalwa: 15 Utshazimpuzi 2021
Hlaziya Umhla: 27 Eyedwarha 2024
Anonim
Tafenoquine: Malaria Drug Development
Ividiyo: Tafenoquine: Malaria Drug Development

Umxholo

I-Tafenoquine (Krintafel) isetyenziselwa ukuthintela ukubuya kwesifo seengcongconi (isifo esosulelayo esisasazwa ziingcongconi kwiindawo ezithile zehlabathi kwaye sinokubangela ukufa) kubantu abaneminyaka eli-16 ubudala nangaphezulu abosulelekileyo kwaye ngoku bafumana ichloroquine okanye ihydroxychloroquine ukunyanga isifo seengcongconi. I-Tafenoquine (Arakoda) isetyenziselwa iyodwa ukuthintela isifo seengcongconi kubahambi abatyelela iindawo apho isifo seengcongconi siqhelekile. I-Tafenoquine ikudidi lwamayeza abizwa ngokuba zii-antimalarials. Isebenza ngokubulala izinto ezibanga isifo seengcongconi.

I-Tafenoquine iza njengecwecwe lokuthatha ngomlomo ngokutya. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-tafenoquine ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uthatha i-tafenoquine (Krintafel) ukuthintela isifo seengcongconi ukuba singabuyi, sihlala sithathwa njengedosi enye (iipilisi ezimbini) kusuku lokuqala okanye lwesibini lonyango lwakho nge-chloroquine okanye i-hydroxychloroquine.


Ukuba uthatha i-tafenoquine (Arakoda) ukuthintela isifo seengcongconi, idosi enye (iipilisi ezimbini) zihlala zithathwa kanye ngemini kangangeentsuku ezi-3, ukuqala kwiintsuku ezi-3 ngaphambi kokuya kwindawo apho kukho isifo seengcongconi. Ngelixa ukule ndawo, idosi enye (iipilisi ezimbini) zihlala zithathwa kanye ngeveki kwangolo suku lunye lweveki. Emva kokuba ubuyile kuloo ndawo, idosi enye (iipilisi ezimbini) zihlala zithathwa kwiintsuku ezisi-7 emva kwedosi yokugqibela ethathwe phambi kokuba ubuye. Akufanele uthathe i-tafenoquine (Arakoda) yokuthintela isifo seengcongconi ngaphezulu kweenyanga ezi-6.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kweyure emva kokuba uthathe i-tafenoquine (Krintafel), tsalela ugqirha wakho. Kuya kufuneka ukuba uthathe elinye idosi yolu nyango.

Thatha i-tafenoquine de ugqibe ubugqirha, nokuba uziva ungcono. Ukuba uyeka ukuthatha i-tafenoquine kwakamsinya okanye weqe amathamo, usulelo lwakho alunakuphathwa ngokupheleleyo okanye awunakukhuseleka kusulelo oluzayo.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana ukuba uthatha iTafenoquine (Krintafel). Ukuba uthatha i-tafenoquine (Arakoda), ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.


Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-tafenoquine,

  • xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-tafenoquine, primaquine, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-tafenoquine.
  • xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: dofetilide (Tikosyn) kunye ne-metformin (Fortamet, Glucophage, Riomet, in Actoplus Met, abanye). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
  • xelela ugqirha wakho ukuba une-glucose-6-phosphate dehydrogenase (G-6-PD) ukuswela (isifo eselifa legazi). Ugqirha wakho uya kukuxelela ukuba ungathathi i-tafenoquine. Xelela ugqirha wakho ukuba ukhe wakha uneengxaki zempilo yengqondo. Ugqirha wakho unokukuxelela ukuba ungathathi i-tafenoquine.
  • xelela ugqirha wakho ukuba ukhe wanayo i-hemolytic anemia (imeko enenani eliphantsi ngokungaqhelekanga leeseli ezibomvu zegazi), i-methemoglobinemia (imeko eneeseli ezibomvu ezinegazi ezingakwaziyo ukuthwala ioksijini ukuya kwizicwili emzimbeni), nicotinamide ukusilela kwe-adenine dinucleotide (NADH) (imeko yemfuza), okanye isifo sezintso okanye sesibindi.
  • xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi okwiminyaka yokuzala, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye ne-tafenoquine kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zolawulo lokuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-tafenoquine, biza ugqirha ngokukhawuleza. I-Tafenoquine inokulimaza umbungu.
  • xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.


Fowunela ugqirha okanye usokhemesti akubuze ukuba wenzeni xa uphoswa yidosi ye-tafenoquine (Arakoda)

I-Tafenoquine inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

  • isicaphucaphu
  • ukugabha
  • urhudo
  • ubunzima bokulala okanye ukulala
  • ixhala
  • utshintsho kwiimvakalelo
  • amaphupha angaqhelekanga
  • intloko ebuhlungu
  • iingxaki zombono, kubandakanya ukungaboni kakuhle okanye ubuntununtunu ekukhanyeni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

  • irhashalala
  • urhwebo
  • ukudumba kwamehlo, ubuso, imilebe, ulwimi, umlomo, okanye umqala
  • ubunzima bokuphefumla okanye ukugwinya
  • ukuqhawukelwa ngumphefumlo
  • ukudinwa okanye ukuqina komqala
  • umchamo omnyama ngombala
  • Umbala ongwevu-luhlaza wemilebe kunye / okanye ulusu
  • isiyezi
  • ukudideka
  • ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi angabikho)
  • ukukhohlisa (ukuba neengcinga ezingaqhelekanga okanye iinkolelo ezingenasiseko kwinyani) ezinje ngeengcinga abantu abazama ukukwenzakalisa nokuba azikho
  • intloko elula
  • mthubi ulusu okanye amehlo

I-Tafenoquine inokubangela ezinye iziphumo ebezingalindelekanga.Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-tafenoquine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

  • Arakoda®
  • Krintafel®
Ukuhlaziywa kokugqibela-02/15/2021

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