Uvavanyo lweKlinikhi oluKhethekileyo luthetha ukuba asisoloko sazi ukuba amayeza abachaphazela njani abantu basetyhini

Umxholo

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Mhlawumbi sele uyazi ukuba ukuthatha i-aspirin kunokuba luncedo ekuthinteleni ukuhlaselwa yintliziyo-sisiseko seBayer Aspirin yomkhankaso wentengiso uphela. Kodwa mhlawumbi awuyazi into yokuba uphononongo oludumileyo lwango-1989 oluye lwaqinisa ukusebenza kwechiza kwezi meko lubandakanya ngaphezulu kwama-20,000 amadoda-kunye nabafazi abaziro.

Kutheni kunje? Kuninzi lwembali yezonyango, amadoda (kunye nezilwanyana ezingamadoda) ziye zaba "ziihagu zeguinea" kwiziphumo zovavanyo, iidosi, kunye neziphumo ebezingalindelekanga ziye zalinganiswa kwizifundo zamadoda okanye ezingamadoda ngokupheleleyo. Kumayeza anamhlanje, amadoda abeyimodeli; abafazi badla ngokuba yingcinga engemva.

Ngelishwa, imeko yokujonga ngokungaphaya kwiziphumo zamayeza kwabasetyhini iyaqhubeka nanamhlanje. Ngo-2013, kwiminyaka engama-20 emva kokuba ichiza laqala ukubakho, uLawulo lokuTya kunye noLawulo lweziyobisi (i-FDA) lisike idosi ecetyiswayo ye-Ambien yabasetyhini ngesiqingatha (ukusuka kwi-10 mg ukuya kwi-5 mg yenguqulo ekhutshwayo kwangoko). Kuyavela ukuba abantu basetyhini-iipesenti ezi-5 zabo baxela ukusebenzisa amayeza okulala amayeza xa kuthelekiswa neepesenti ezi-3 kuphela zamadoda-ziqhubekeka ichiza ngokuthe chu kunamadoda, oko kuthetha ukuba bazokuziva bediniwe emini kwidosi ephezulu. Esi siphumo secala siza nefuthe elibi, kubandakanya neengozi zokuqhuba.

Olunye uphando lubonisa ukuba abasetyhini basabela kumayeza awahlukeneyo ngokwahlukileyo emadodeni. Umzekelo, kolunye uvavanyo, abathathi-nxaxheba abangamadoda abathatha ii-statins babenobuncinane bokuhlaselwa yintliziyo kunye nemivumbo, kodwa izigulana zabasetyhini azibonisanga mpembelelo mikhulu. Ke kunokuba, kunokuba yingozi ukumisela i-statins-ehlala iza neziphumo ebezingalindelekanga ezingathandekiyo-kwabasetyhini abanomngcipheko weengxaki zentliziyo.

Ngamanye amaxesha, abasetyhini benza ngcono kunamadoda kwi-SSRI antidepressants, kwaye olunye uphando lubonisa ukuba amadoda anempumelelo enkulu kwiziyobisi ze-tricyclic. Kwakhona, abasetyhini abakhotyokiswe yi-cocaine babonisa umahluko kwimisebenzi yengqondo xa kuthelekiswa namadoda, becebisa indlela abantu ababhinqileyo abanokuxhomekeka ngayo kwichiza ngokukhawuleza. Ke ngoko, ukushiya iimodeli zabasetyhini ngaphandle kwezifundo zokulutha, umzekelo, kunokuba nefuthe elibi kumachiza kunye nemigangatho yokhathalelo ethi kamva iphuhliswe ukunceda abakhotyokisiweyo.

Siyazi kananjalo ukuba abasetyhini babonakalisa iimpawu ezahlukeneyo kwizigulo ezimandundu. Xa abantu ababhinqileyo behlaselwa sisifo sentliziyo, umzekelo, banokuthi okanye bangaziva besiva iintlungu zesifuba. Endaweni yoko, kunokwenzeka ngakumbi kunamadoda ukuba afumane ukuphefumla okufutshane, ukubila okubandayo, kunye nentloko elula. Nangona isondo ayisiyonto iphambili kuyo yonke imiba yempilo, xa kunjalo, ihlala iyingozi.

"Asikazi ukuba ingaba [isondo] siza kuba yinto ebalulekileyo kuyo yonke imeko yokugula, kuyo yonke imeko, kodwa kufuneka sazi ukuba ibaluleke nini," utshilo uPhyllis Greenberger, umongameli kunye ne-CEO yoMbutho weMpilo yabaseTyhini Uphando. Ebesandula ukuba yinxalenye yenkomfa yokuxoxa malunga nendima yokwahluka kwezesondo kuphando lwezonyango, axhaswe ngumbutho wakhe kunye noMbutho we-Endocrine.

Umbutho kaGreenberger wawubalulekile ekuncedeni ukudlula koMthetho wokuVuselelwa kwe-NIH we-1993, owawufuna ukuba onke amaZiko ezeMpilo eSizwe (NIH) afumane inkxaso-mali yolingo lwezonyango ukubandakanya abasetyhini kunye nabathathi-nxaxheba abambalwa. Okwangoku, eli qela lelinye labaninzi abasebenza ukufumana ingqalelo efanayo yezilwanyana kunye neeseli ezisetyenziswa kuphando lwe-preclinical-hayi abantu kuphela.

Ngombulelo, i-NIH ityhala ukwenza utshintsho olusisigxina kuphando. Ukuqala ngoSeptemba wonyaka ophelileyo, yaqala ukwazisa uluhlu lwemigaqo-nkqubo, imimiselo, kunye nezibonelelo zokukhuthaza ukukhuthaza (kwaye kwiimeko ezininzi kunyanzelekile) abaphandi ukuba baqaphele isondo sebhayoloji njengento ebalulekileyo kumsebenzi wabo. [Funda ibali elipheleleyo ku Refinery29!]

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