Rimonabant ukunciphisa umzimba

Umxholo

• Kusetyenziswa kwanjani
• Indlela yokusebenza
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Ukungqinelana

I-rimonabant eyaziwa ngokuthengisa njenge-Acomplia okanye iRedufast, liyeza elalisetyenziselwa ukunciphisa umzimba, kunye nokusebenza kwenkqubo ye-nervous system ekunciphiseni ukutya.

Eli yeza lisebenza ngokuthintela ii-receptors kwingqondo nakwizitho zepheripherali, ukunciphisa ukungasebenzi kakuhle kwenkqubo ye-endocannabinoid, ekhokelela ekunciphiseni ukutya, ukulawulwa kobunzima bomzimba kunye nokulinganisela kwamandla, kunye nokucolwa kweswekile kunye namafutha, oko kunceda ukunciphisa umzimba.

Ngaphandle kokusebenza kwawo, ukuthengiswa kwala machiza kunqunyanyisiwe ngenxa yomngcipheko okhulayo wokuba neengxaki zengqondo.

Kusetyenziswa kwanjani

Ukusetyenziswa kwe-rimonabant yithebhulethi enye ye-20 mg yonke imihla, kusasa ngaphambi kwesidlo sakusasa, ngomlomo, sithathiwe siphelele, ngaphandle kokophulwa okanye ukuhlafunwa. Unyango kufuneka lukhatshwe kukutya okuneekhalori ezisezantsi kunye nokwanda kwinqanaba lomsebenzi womzimba.

Umthamo ocetyiswayo we-20 mg ngosuku akufuneki udlule, ngenxa yomngcipheko okhulayo weziganeko ezibi.

Indlela yokusebenza

URimonabant ngumchasi wee-cannabinoid receptors kwaye usebenza ngokuthintela uhlobo oluthile lwee-receptors ze-cannabinoid ezibizwa ngokuba yi-CB1, ezifumaneka kwinkqubo yemithambo-luvo kwaye ziyinxalenye yenkqubo esetyenziswa ngumzimba ukulawula ukutya. Ezi receptors zikhona nakwii-adipocyte, eziziiseli zethambo le-adipose.

Iziphumo ebezingalindelekanga ezinokwenzeka

Iziphumo ebezingalindelekanga ezinokubangelwa leli yeza sisicaphucaphu kunye nosulelo oluphezulu lokuphefumla, ukungonwabi sisisu, ukugabha, ukuphazamiseka kokulala, uloyiko, ukudakumba, uburhalarhume, isiyezi, urhudo, unxunguphalo, ukurhawuzelela, ukubila okugqithisileyo, inkantsi yezihlunu okanye ukudumba, ukudinwa, amabala amnyama, iintlungu kunye nokudumba kwiimisipha, ukulahleka kwememori, iintlungu zangasemva, ukutshintsha ubuntununtunu ezandleni nasezinyaweni, ukuqhuma okushushu, umkhuhlane kunye nokudakumba, ukozela, ukubila ebusuku, iihiccups, umsindo.

Ukongeza, iimpawu zokoyika, ukungazinzi, ukuphazamiseka ngokweemvakalelo, iingcinga zokuzibulala, ukuba ndlongondlongo okanye isimilo esinoburharha sinokuvela.

Ukungqinelana

Okwangoku, i-ribonabant iyaphikiswa kubemi bonke, ikhutshiwe kwimarike ngenxa yeziphumo zayo ebezingalindelekanga.

Ngexesha lokuthengisa kwayo, ukusetyenziswa kwayo kwakungacetyiswa kwabasetyhini abakhulelweyo, ngexesha lokuncancisa, kubantwana abangaphantsi kwe-18, abantu abane-hepatic okanye i-renal insufficiency okanye nangayiphi na imeko yokungalawuleki kwengqondo.