I-Goodpasture syndrome: yintoni, iimpawu, oonobangela kunye nonyango

Umxholo

• Iimpawu eziphambili
• Indlela yokuqinisekisa ukuxilongwa
• Izizathu ezinokubangela
• Unyango lwenziwa njani

Isifo seGoodpasture Syndrome sisifo esinqabileyo somzimba, apho iiseli zokhuselo lomzimba zihlasela izintso nemiphunga, ikakhulu zibangela iimpawu ezinjengokukhohlela okunegazi, ukuphefumla nzima kunye nokuphulukana negazi kumchamo.

Esi sifo senzeka ngenxa yobukho beentsholongwane ezihlasela iiseli zezintso nemiphunga. Ezinye zezinto ezibonakala ngathi zonyusa umngcipheko wokuba nesi sifo zezi: ukuba nembali yesi sifo kunye nokutshaya, ukuba nezifo zokuphefumla eziphindaphindayo kunye nokuvezwa kukufuthwa kwezinto ezinje nge methane okanye ipropane, umzekelo.

Unyango lusekwe kusetyenziso lwamayeza anje nge-immunosuppressants kunye ne-corticosteroids, kodwa kwiimeko ezinzima kakhulu, i-plasmapheresis okanye i-hemodialysis ingafuneka.

Iimpawu eziphambili

Iimpawu eziphambili ze-Goodpasture Syndrome zezi:

• Ukudinwa kakhulu;
• Ukukhohlela igazi;
• Ubunzima bokuphefumla;
• Iintlungu xa uphefumla;
• Ukunyuka kwamazinga e-urea egazini;
• Ubukho begazi kunye / okanye igwebu kumchamo;
• Ukutsha xa uchama.

Xa iimpawu zivela, kuyacetyiswa ukuba ufune unyango ngokukhawuleza kwiimviwo kunye nokubonisa olona nyango lufanelekileyo, njengoko iimpawu zinokuba mandundu ukuba isifo asinyangwa kwangethuba.

Ukongeza, ezinye izifo zinokuba neempawu ezifanayo nezo zesi sifo, ezinje nge-Wegener granulomatosis, eyenza ukuba kube nzima ukuxilongwa. Zazi iimpawu kunye nendlela yokunyanga i-Wegener's granulomatosis.

Indlela yokuqinisekisa ukuxilongwa

Ukuchonga isifo seGoodpasture's syndrome, ugqirha uya kuvavanya imbali yakho yezempilo kunye nexesha lweempawu zakho. Emva koko, ugqirha unokuyalela iimvavanyo ezithile, ezinje ngegazi kunye nomchamo, ukuze achonge izilwa-buhlungu eziveliswa ngumzimba ezibangela isifo seGoodpasture's.

ezifana ne-kidney biopsy, ekususeni icandelo elincinci lezicubu zezintso, ukubona ukuba kukho iiseli ezibangela isifo seGoodpasture's.

Ukongeza, ugqirha unokuyalela ezinye iimvavanyo, ezinje nge-biopsy yezintso, ebandakanya ukususa indawo encinci yezicubu zezintso eziza kuvavanywa elebhu, ukuze kukhangelwe ukuba kukho iiseli ezibangela isifo sikaGoodpasture.

I-X-ray kunye ne-CT scans nazo zinoku-odolwa ngugqirha wakho ukubona umonakalo wemiphunga. Bona iinkcukacha ezithe kratya malunga nendlela eyenziwa ngayo ikhompyutha yetomography.

Izizathu ezinokubangela

Unobangela wesifo seGoodpasture's syndrome ngenxa ye-anti-GBM antibodies ehlasela i-NC-1 yenxalenye yohlobo IV collagen kwizintso nakwiiseli zemiphunga.

Esi sifo sibonakala siqhelekile emadodeni kunabafazi, phakathi kweminyaka engama-20 ukuya kwengama-30 ubudala, nakubantu abanolusu olukhanyayo. Ukongeza, ukubhencwa kwimichiza efana nezibulala-zinambuzane, umsi wecuba, kunye nosulelo olubangelwa ziintsholongwane zezinye zezinto ezibonakala ngathi zonyusa umngcipheko wokuba nesifo, njengoko zinokubangela ukuba iiseli zokhuselo lomzimba zihlasele imiphunga nemiphunga.

Unyango lwenziwa njani

Unyango lwe-Goodpasture's Syndrome luhlala lwenziwa esibhedlele kwaye lusekwe ekusetyenzisweni kwamachiza okunyanga umzimba kunye ne-corticosteroids, ethintela iiseli zokhuselo lomzimba ekutshabalaliseni izintso nemiphunga.

Kwezinye iimeko, unyango lwe-plasmapheresis luboniswa, yinkqubo ehluza igazi kwaye yahlule izilwa-buhlungu eziyingozi kwizintso nemiphunga. Ukuba izintso zichaphazeleke kakhulu, ukufunwa kwehemodialysis okanye ukufakelwa kwezintso kunokufuneka. Ukuqonda ngcono ukuba yintoni i-plasmapheresis kunye nendlela eyenziwa ngayo.