Uvavanyo lweSmooth Musbody Antibody (SMA)

Umxholo

• Luyintoni uvavanyo lwe-SMA egudileyo yemisipha?
• Isetyenziselwa ntoni?
• Kutheni ndifuna uvavanyo lweSMA?
• Kwenzeka ntoni ngexesha lovavanyo lweSMA?
• Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?
• Ngaba bukhona ubungozi kuvavanyo?
• Zithetha ntoni iziphumo?
• Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lweSMA?
• Izalathiso

Luyintoni uvavanyo lwe-SMA egudileyo yemisipha?

Olu vavanyo lukhangela ii-antibodies zemisipha egudileyo (SMAs) egazini. I-antibody egudileyo yemisipha (i-SMA) luhlobo lwe-antibody eyaziwa ngokuba yi-autoantibody. Ngokwesiqhelo, amajoni akho omzimba enza ukuba amajoni omzimba ahlasele izinto zangaphandle ezinjengeentsholongwane kunye neebhaktiriya. I-autoantibody ihlasela iiseli zomzimba kunye nezicubu ngempazamo. Ii-SMAs zihlasela izicubu zemisipha egudileyo esibindini nakwamanye amalungu omzimba.

Ukuba ii-SMAs zifunyenwe egazini lakho, kusenokwenzeka ukuba une-hepatitis yokuzimela. I-autoimmune hepatitis sisifo apho amajoni omzimba ahlasela izicwili zesibindi. Kukho iintlobo ezimbini ze-hepatitis ezenzekelayo:

• Uhlobo lwe-1, lolona hlobo luqhelekileyo lwesifo. Uhlobo lwe-1 luchaphazela abafazi abaninzi kunamadoda. Kuqheleke kakhulu kubantu abanesinye isifo sokuzimela.
• Uhlobo lwe-2, uhlobo olungaqhelekanga kwesi sifo. Uhlobo lwe-2 ikakhulu luchaphazela amantombazana aphakathi kweminyaka emi-2 neli-14.

I-autoimmune hepatitis inokulawulwa ngamayeza acinezela amajoni omzimba. Unyango lusebenza ngakumbi xa isifo sifunyenwe kwangethuba. Ngaphandle konyango, i-autoimmune hepatitis inokubangela iingxaki ezinkulu zempilo, kubandakanya i-cirrhosis kunye nokusilela kwesibindi.

Amanye amagama: anti-egudileyo yemisipha, i-ASMA, i-actin antibody, i-ACTA

Isetyenziselwa ntoni?

Uvavanyo lwe-SMA lusetyenziselwa ikakhulu ukufumanisa isifo sokuqina kwesifo somzimba. Kukwasetyenziselwa ukufumanisa ukuba ngaba ingxaki luhlobo 1 okanye uhlobo 2.

Iimvavanyo ze-SMA zihlala zisetyenziswa kunye nolunye uvavanyo ukunceda ukuqinisekisa okanye ukukhupha isifo se-hepatitis. Olu vavanyo lubandakanya:

• Uvavanyo lwe-F-actin antibodies. I-F-actin yiprotein efumaneka kwizicwili ezigudileyo zesibindi nakwezinye iindawo zomzimba. Iintsholongwane ze-F-actin zihlasela ezi zihlunu zisempilweni.
• Uvavanyo lwe-ANA (anti-nuclear antibody). Ii-ANA ngamajoni omzimba ahlasela i-nucleus (embindini) yeeseli ezithile ezisempilweni.
• I-ALT (alanine transaminase) kunye ne-AST (aspartate aminotransferase) kuvavanyo. I-ALT kunye ne-AST zii-enzymes ezimbini ezenziwe sisibindi.

Kutheni ndifuna uvavanyo lweSMA?

Unokulufuna olu vavanyo ukuba wena okanye umntwana wakho uneempawu zesifo sokuqina kwesibindi. Oku kubandakanya:

• Ukudinwa
• IJaundice (imeko ebangela ulusu kunye namehlo ajike abe tyheli)
• Intlungu zesisu
• Intlungu edibeneyo
• Isicaphucaphu
• Irhashalala
• Ukuphelelwa ngumdla wokutya
• Umchamo omnyama-mnyama

Kwenzeka ntoni ngexesha lovavanyo lweSMA?

Ingcali yokhathalelo lwempilo iyakuthatha isampulu yegazi kumthambo engalweni yakho, isebenzisa inaliti encinci. Emva kokuba inaliti ifakiwe, inani elincinci legazi liya kuqokelelwa kwityhubhu yovavanyo okanye igutyana. Unokuziva uluma kancinci xa inaliti ingena okanye iphuma. Oku kuhlala kuthatha imizuzu engaphantsi kwesihlanu.

Ngaba kuya kufuneka ndenze nantoni na ukulungiselela uvavanyo?

Awudingi naluphi na ulungiselelo olukhethekileyo lovavanyo lwe-SMA.

Ngaba bukhona ubungozi kuvavanyo?

Mncinci kakhulu umngcipheko wokuvavanywa kwegazi. Unokuba nentlungu encinci okanye ukrakra kwindawo apho inaliti yafakwa khona, kodwa uninzi lweempawu zihamba ngokukhawuleza.

Zithetha ntoni iziphumo?

Ukuba iziphumo zakho zibonisa inani eliphezulu lee-antibodies ze-SMA, mhlawumbi kuthetha ukuba unohlobo lwe-1 lwe-hepatitis yokuzimela. Inani elisezantsi linokuthetha ukuba unohlobo lwesi-2 sesi sifo.

Ukuba akukho zifunyenwe ii-SMAs, oko kuthetha ukuba iimpawu zesibindi zibangelwa yinto eyahlukileyo kune-autoimmune hepatitis. Umboneleli wakho wokhathalelo lwempilo uyakufuna uku-odola iimvavanyo ezingaphezulu ukuze enze isifo.

Ukuba unemibuzo malunga neziphumo zakho, thetha nomboneleli wakho wezempilo.

Funda ngakumbi malunga novavanyo lwelabhoratri, uluhlu lweereferensi, kunye neziphumo zokuqonda.

Ngaba ikhona enye into endifuna ukuyazi malunga novavanyo lweSMA?

Ukuba iziphumo zakho zibonise ukuba wena okanye umntwana wakho unama-antibodies e-SMA, umboneleli wakho unokuyalela i-biopsy yesibindi ukuqinisekisa ukuxilongwa kwe-hepatitis. I-biopsy yinkqubo esusa isampulu encinci yezicubu zovavanyo.

Izalathiso

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5. Ikliniki yaseMayo [kwi-Intanethi]. Isiseko seMayo seMfundo yezoNyango noPhando; c1998–2019. I-autoimmune hepatitis: Iimpawu kunye noonobangela; I-2018 Sep 12 [icatshulwe nge-2019 ka-Aug 19]; [malunga nezikrini ezi-3]. Ifumaneka kwi: https://www.mayoclinic.org/diseases-conditions/autoimmune-hepatitis/symptoms-causes/syc-20352153
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Ulwazi olukule ndawo akufuneki lusetyenziswe endaweni yonyango okanye iingcebiso. Nxibelelana nomboneleli wezempilo ukuba unemibuzo malunga nempilo yakho.