Ngaba iVitamin D ingawunciphisa umngcipheko we-COVID-19?

Umxholo

• I-vitamin D iyichaphazela njani impilo yomzimba?
• Ngaba ukuthatha ivithamin D kunokukhusela kwi-COVID-19?
• Umgca wezantsi

I-Vitamin D yivitamin enyibilikayo edlala amanqatha edlala indima ebalulekileyo emzimbeni wakho.

Esi sondlo sibaluleke kakhulu kwimpilo yamajoni omzimba, sishiya abantu abaninzi bezibuza ukuba ukuxhasa ivithamin D kunganceda ukunciphisa umngcipheko wokufumana ikhoronavirus entsha ebangela i-COVID-19.

Ngelixa okwangoku kungekho lunyango lwe-COVID-19, amanyathelo othintelo njengokuhamba emzimbeni kunye nococeko olufanelekileyo kunokukukhusela ekufumaneni intsholongwane.

Kwakhona, olunye uphando lubonisa ukuba amanqanaba asempilweni e-vitamin D anokunceda ukugcina amajoni akho omzimba esempilweni kwaye anokukhusela kwizifo zokuphefumla ngokubanzi.

Uphononongo lwamva nje lubonise ukuba abaguli abalaliswe esibhedlele nge-COVID-19 abanamanqanaba aneleyo e-vitamin D abanomngcipheko ophunguliweyo weziphumo ezibi kunye nokufa ().

Eli nqaku lichaza ukuba ivithamin D iyichaphazela njani impilo yamajoni omzimba kunye nendlela ukuxhasa ngayo le sondlo kunokunceda ekukhuseleni iimeko zokuphefumla.

I-vitamin D iyichaphazela njani impilo yomzimba?

I-Vitamin D iyimfuneko ekusebenzeni kakuhle kwamajoni akho omzimba - owona mzila wokuqala womzimba wakho ekukhuseleni izifo kunye nezifo.

Le vithamini idlala indima ebalulekileyo ekukhuthazeni ukuphendula komzimba. Inazo zombini iipropathi ezichasene nokuvuvukala kunye nokugonywa, kwaye kubalulekile ekusebenzeni kokukhusela amajoni omzimba ().

I-Vitamin D yaziwa ngokuba yeyokukhulisa ukusebenza kweeseli zomzimba, kubandakanya iiseli ze-T kunye nee-macrophage, ezikhusela umzimba wakho kumagciwane ().

Ngapha koko, ivithamini ibaluleke kakhulu ekusebenzeni komzimba ukuba amanqanaba asezantsi e-vitamin D adityaniswe nokwanda kokuchaphazeleka kusulelo, izifo, kunye nokuphazamiseka okunxulumene nomzimba ().

Umzekelo, amanqanaba asezantsi e-vitamin D ayanyaniswa nomngcipheko owonyukayo wezifo zokuphefumla, kubandakanya isifo sephepha, isifuba, kunye nesifo esinganyangekiyo semiphunga (COPD), kunye nosulelo lokuphefumla kwintsholongwane kunye neentsholongwane (,,,).

Ngaphezu koko, ukuswela ivithamin D kunxulunyaniswe nokwehla kokusebenza kwemiphunga, okunokuchaphazela amandla omzimba wakho wokulwa izifo zokuphefumla (,).

I-Vitamin D ibalulekile ekusebenzeni komzimba. Ukusilela kwesi sondlo kunokubeka esichengeni ukuphendula komzimba kunye nokwandisa umngcipheko wosulelo kunye nezifo.

Ngaba ukuthatha ivithamin D kunokukhusela kwi-COVID-19?

Okwangoku, akukho lunyango okanye unyango lwe-COVID-19, kwaye zimbalwa izifundo eziye zaphanda isiphumo sevithamin D yokuncedisa okanye ukusilela kwe-vitamin D emngciphekweni wokufumana i-coronavirus entsha, i-SARS-CoV-2.

Nangona kunjalo, uphononongo lwamva nje luchonge ukuba inqanaba legazi le-25-hydroxyvitamin D ye-30 ng / mL ebonakala ngathi iyanceda ukunciphisa amathuba okuba neziphumo ezibi zeklinikhi kunye nokufa kwizigulana ezibhedlele ezine-COVID-19.

Idatha yesibhedlele yezigulana ezingama-235 ezine-COVID-19 zahlalutywa.

Kwizigulana ezindala kuneminyaka yobudala engama-40, abo babenamanqanaba aneleyo e-vitamin D babengama-51.5% amathuba okuba neziphumo ezibi, kubandakanya ukungazi nto, i-hypoxia, kunye nokufa, xa kuthelekiswa nezigulana ezinesiphene se-vitamin D. ().

Okwangoku, olunye uphononongo lubonakalisile ukuba ukunqongophala kukavithamin D kungonakalisa ukusebenza komzimba kunye nokwandisa umngcipheko wokuba nezifo zokuphefumla ().

Ukongeza, ezinye izifundo zibonise ukuba izongezo zevithamin D zinokunyusa ukuphendula komzimba kunye nokukhusela kwizifo zokuphefumla ngokubanzi.

Uphengululo lwamva nje olubandakanya abantu abali-11,321 abavela kumazwe ayi-14 babonisa ukuba ukongeza ivithamin D kunciphise umngcipheko wezifo zokuphefumla (i-ARI) kubo bobabini abanamanqanaba asweleyo kunye neevithamini D.

Ngokubanzi, uphononongo lubonise ukuba izongezo ze vithamin D zinciphise umngcipheko wokuphuhlisa i-ARI enye nge-12%. Iziphumo zokuzikhusela zazinamandla kwabo banamanqanaba asezantsi e-vitamin D ().

Ngaphaya koko, uphononongo lufumanise ukuba izongezo zevithamini D zazisebenza kakhulu ekukhuseleni i-ARI xa zithathwa yonke imihla okanye ngeveki ngeedosi ezincinci kwaye zingasebenzi kakuhle xa zithathwa kumanani amakhulu, ahlukeneyo ().

Izongezo zeVitamin D zikwabonakalisiwe ukunciphisa ukusweleka kubantu abadala, abona basemngciphekweni wokuhlaselwa sisifo sokuphefumla njenge-COVID-19 ().

Ngaphezu koko, ukuswela ivithamin D kuyaziwa ukuphucula inkqubo eyaziwa ngokuba yi "cytokine storm" ().

IiCytokines ziiproteni eziyinxalenye yenkqubo yomzimba yokuzikhusela. Banokuba nefuthe lokudumba kunye nokuchasana nokudlala indima ebalulekileyo, ekuncedeni ukukhusela kusulelo nakwizifo (,).

Nangona kunjalo, ii-cytokines zinokubangela nomonakalo wethishu phantsi kweemeko ezithile.

Isiqhwithi se-cytokine sibhekisa ekukhululweni okungalawulekiyo kwee-cytokines zepro-inflammatory ezenzeka ngokuphendula kusulelo okanye ezinye izinto. Ukukhutshwa okungalawulekiyo kunye nokugqithisileyo kwee-cytokines kukhokelela ekonakaleni kwezicubu kwaye kuphucula ukuqhubela phambili kwesifo kunye nobukrakra ().

Ngapha koko, sesona sizathu siphambili sokungaphumeleli kwamalungu kunye nesifo sokuphefumla esiqatha (i-ARDS), kunye nomba obalulekileyo ekuqhubekeni nasekubukhali kwe-COVID-19 ().

Umzekelo, izigulana ezinamatyala amabi e-COVID-19 zibonisiwe ukuba zikhupha inani elikhulu lee-cytokines, ngakumbi i-interleukin-1 (IL-1) kunye ne-interleukin-6 (IL-6) ().

Ukunqongophala kweVitamin D kunxulunyaniswe nokuncitshiswa komzimba kwaye kunokuphucula isiqhwithi secytokine.

Kananjalo, abaphandi bafaka ukuba ukusilela kwe-vitamin D kunokunyusa umngcipheko we-COVID-19 ezinzima, kunye nokongezwa kwe-vitamin D kunokunciphisa iingxaki ezinxulumene neenkqwithela ze-cytokine kunye nokudumba okungalawulwayo kubantu abane-COVID-19 (, 21).

Okwangoku, iimvavanyo ezininzi zeklinikhi ziphanda iziphumo zokuncedisa i-vitamin D (kwiidosi ukuya kuthi ga kwi-200,000 IU) kubantu abane-COVID-19 (, 22).

Nangona uphando kule ndawo luqhubeka, kubalulekile ukuqonda ukuba ukuthatha i-vitamin D eyongezelelweyo ayikwazi ukukhusela ekuphuhliseni i-COVID-19.

Nangona kunjalo, ukusilela kwivithamini D kunokunyusa ukubakho kwakho kusulelo kunye nezifo ngokwenzakalisa ukusebenza komzimba.

Oku kuyakhathaza ngakumbi ngenxa yokuba abantu abaninzi banengxaki ye-vitamin D, ngakumbi abantu abadala abasemngciphekweni wokuphuhliswa kweengxaki ezinxulumene ne-COVID-19 ().

Ngenxa yezi zizathu, licebo elihle ukuba umboneleli wakho wezempilo avavanye amanqanaba akho e-vitamin D ukumisela ukuba ngaba unentsilelo kwesi sondlo sibalulekileyo. Oku kubaluleke ngakumbi ebusika.

Kuxhomekeka kumanqanaba egazi, ukongeza nge-1,000-4,000 IU ye-vitamin D ngemini yanele abantu abaninzi. Nangona kunjalo, abo banamanqanaba asezantsi egazi bahlala befuna iidosi eziphezulu kakhulu ukunyusa amanqanaba abo kwinqanaba elifanelekileyo ().

Nangona izindululo malunga nokuba yintoni inqanaba elifanelekileyo le-vitamin D ziyahluka, uninzi lweengcali ziyavuma ukuba amanqanaba aphezulu e-vitamin D aphakathi kwe-30-60 ng / mL (75-150 nmol / L) (,).

Nangona uphando luqhubeka, ubungqina bokuba isongezelelo se-vitamin D sinciphisa umngcipheko wokuphuhlisa i-COVID-19 isasikelwe umda. Ukuba nenqanaba le-vitamin D esempilweni kunokuphucula impilo yomzimba kwaye kunokuba luncedo kubantu abane-COVID-19.

Umgca wezantsi

I-Vitamin D idlala indima ebalulekileyo emzimbeni wakho, kubandakanya ukukhuthaza impilo yomzimba wakho.

Uphando lobunzululwazi lucebisa ukuba ukuxhasa ivithamin D kunokukhusela kwizifo zokuphefumla, ngakumbi kwabo banesiphene kwivithamini.

Uphando lwamva nje lubonisa ukuba amanqanaba e-vitamin D aneleyo anokunceda abantu abane-COVID-19 ukunqanda iziphumo ezibi.

Okwangoku, asazi nokuba ukuthatha izongezo ze vithamin D kunciphisa umngcipheko wokuphuhlisa i-COVID-19 njengesiphumo sokufumana ikoronavirus.

Thetha nogqirha wakho malunga nokuxhasa ivithamin D ukuphucula impendulo yakho yomzimba.