Glucagonoma

I-Glucagonoma sisisu esinqabileyo kakhulu seeslet zeseli zepancreas, ekhokelela ekugqithiseni kwehomoni yeglucagon egazini.

I-Glucagonoma ihlala inomhlaza (imbi). Umhlaza uhlala usasazeka kwaye uya usiba mbi.

Lo mhlaza uchaphazela iiseli zesqhekeza zepancreas. Ngenxa yoko, iiseli ze-islet zivelisa kakhulu i-hormone yeglucagon.

Unobangela awaziwa. Izinto zemfuza zidlala indima kwezinye iimeko. Imbali yosapho yesifo se-endocrine neoplasia yohlobo I (MEN I) yinto eyingozi.

Iimpawu zeglucagonoma zinokubandakanya oku kulandelayo:

• Ukunganyamezelani ngeglucose (umzimba unengxaki yokuphula iswekile)
• Iswekile yegazi ephezulu (hyperglycemia)
• Urhudo
• Ukoma kakhulu (ngenxa yeswekile ephezulu yegazi)
• Ukuchama rhoqo (ngenxa yeswekile ephezulu yegazi)
• Ukwanda kwesidlo
• Umlomo nolwimi odumbileyo
• Ixesha lasebusuku (ebusuku) ukuchama
• Ukudumba kolusu ebusweni, isisu, iimpundu, okanye iinyawo eziza kwaye zihambe, kwaye zihamba-hambe
• Ukuhla ukusinda

Kwiimeko ezininzi, umhlaza sele usasazekile waya esibindini xa ufunyaniswe.

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye abuze malunga nembali yakho yonyango kunye neempawu.

Uvavanyo olunokwenziwa lunokubandakanya:

• Ukuvavanywa kwe-CT kwesisu
• Inqanaba leGlucagon egazini
• Inqanaba leswekile egazini

Ugqirha lokususa ithumba kuhlala kucetyiswa. I-tumor ayisoloko iphendula kwi-chemotherapy.

Ungaluphelisa uxinzelelo lokugula ngokujoyina iqela lokuxhasa umhlaza. Ukwabelana nabanye abanamava afanayo kunye neengxaki kunokukunceda ungaziva ulilolo.

Phantse iipesenti ezingama-60 zala mathumba ngumhlaza. Kuqhelekile ukuba lo mhlaza usasazeka esibindini. Bamalunga nama-20% kuphela abantu abanokunyangeka ngotyando.

Ukuba ithumba lisepancreas kuphela kwaye uqhaqho lususwe luyimpumelelo, abantu baneminyaka emi-5 yokusinda ye-85%.

Umhlaza unganwenwela esibindini. Inqanaba leswekile yegazi ephezulu kunokubangela iingxaki kwimetabolism kunye nomonakalo womzimba.

Fowunela umnikezeli wakho ukuba ubona iimpawu zeglucagonoma.

AMADODA I-glucagonoma

• Amadlala endocrine

Kwiwebhusayithi yeZiko loMhlaza weSizwe. Unyango lwepancreatic neuroendocrine tumors (islet cell tumors) unyango (PDQ) -uhlobo lobuchwephesha kwezempilo. www.cancer.gov/types/pancreatic/hp/pnet-kunyanga-pdq. Ukuhlaziywa ngoFebruwari 8, 2018. Ifikeleleke ngoNovemba 12, 2018.

Schneider DF, Mazeh H, Lubner SJ, Jaume JC, Chen H. Umhlaza wenkqubo ye-endocrine. Ku: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, Tepper JE, ii-eds. I-Oncology yeklinikhi yase-Abeloff. Umhla we-5. IPhiladelphia, PA: Elsevier Saunders; 2014: isahl 71.

UVella A. Amadlala emathunjini kunye namathumbu endocrine esiswini. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 38.