Utshintsho oluncinci lwezifo

Isifo esitshintsho esincinci sisifo sezintso esinokukhokelela kwisifo i-nephrotic syndrome. I-Nephrotic syndrome liqela leempawu ezibandakanya iprotheni kumchamo, amanqanaba asezantsi eeproteni egazini, amanqanaba aphezulu e-cholesterol, amanqanaba aphezulu e-triglyceride, kunye nokudumba.

Intso nganye yenziwa ngaphezu kwesigidi seeyunithi ezibizwa ngokuba zii-nephrons, ezicoca igazi zivelise umchamo.

Kwisifo esitshintsho esincinci, kukho umonakalo kwi-glomeruli. Le yimithambo yegazi encinci ngaphakathi kwe-nephron apho igazi lihluzwa ukwenza umchamo kunye nenkunkuma isuswe. Esi sifo sifumana igama laso kuba lo monakalo awubonakali phantsi kwemicroscope yesiqhelo. Ingabonakala kuphela phantsi kwemicroscope enamandla kakhulu ebizwa ngokuba yi-electron microscope.

Isifo esitshintsho esincinci sesona sizathu siqhelekileyo se-nephrotic syndrome ebantwaneni. Kwakhona kubonakala kubantu abadala abane-nephrotic syndrome, kodwa ayiqhelekanga.

Isizathu asaziwa, kodwa esi sifo singenzeka emva okanye sinxulumene:

• Ukunyanga komzimba
• Ukusetyenziswa kweeNSAID
• Amathumba
• Ukugonywa (umkhuhlane kunye ne-pneumococcal, nangona kunqabile)
• Usulelo lwentsholongwane

Kukho iimpawu ze-nephrotic syndrome, kuquka:

• Ukubonakala kwegwebu komchamo
• Ukutya okungafanelekanga
• Ukudumba (ngakumbi ecaleni kwamehlo, iinyawo, kunye namaqatha, nasesiswini)
• Ukutyeba (ukusuka ekugcineni amanzi)

Isifo esincinci sokutshintsha asinciphisi isixa somchamo esivelisiweyo. Ayifane iqhubele phambili ukusilela kwezintso.

Umboneleli wezempilo usenokungakwazi ukubona naziphi na iimpawu zesi sifo, ngaphandle kokudumba. Uvavanyo lwegazi kunye nomchamo lubonisa iimpawu zesifo se-nephrotic, kubandakanya:

• Cholesterol ephezulu
• Amanqanaba aphezulu eprotheni kumchamo
• Amanqanaba asezantsi ealbumin egazini

Uvavanyo lwezintso kunye novavanyo lwethishu ngemicroscope ye-elektroniki kunokubonisa iimpawu zesifo esincinci esitshintshayo.

Amayeza abizwa ngokuba yi-corticosteroids anokunyanga ukutshintsha okuncinci kwesifo kuninzi lwabantwana. Abanye abantwana banokufuna ukuhlala kwii-steroids ukugcina isifo singabuyi.

I-Steroids iyasebenza kubantu abadala, kodwa kuncinci ebantwaneni. Abantu abadala banokuba nokuphindaphinda rhoqo kwaye baxhomekeke kwii-steroids.

Ukuba i-steroids ayisebenzi, umboneleli uya kuphakamisa amanye amayeza.

Ukudumba kunokunyangwa nge:

• Amayeza e-ACE inhibitor
• Ulawulo lwexinzelelo lwegazi
• I-diuretics (iipilisi zamanzi)

Unokuxelelwa ukuba unciphise inani leetyuwa ekutyeni kwakho.

Abantwana bahlala bephendula ngcono kwi-corticosteroids kunabantu abadala. Abantwana bahlala bephendula kwinyanga yokuqala.

Ukubuyela umva kunokwenzeka. Imeko inokuphucuka emva konyango lwexesha elide kunye ne-corticosteroids kunye namayeza acinezela amajoni omzimba (ii-immunosuppressants).

Fowunela umnikezeli wakho ukuba:

• Uba neempawu zesifo esincinci esitshintshayo
• Unale ngxaki kwaye iimpawu zakho ziya zisiba mbi
• Uba neempawu ezintsha, kubandakanya neziphumo ebezingalindelekanga ezivela kumayeza asetyenziselwa ukunyanga esi sifo

Utshintsho oluncinci nephrotic syndrome; Isifo se-Nil; Lipoid nephrosis; Idiopathic nephrotic syndrome yobuntwana

• IGlomerulus kunye nephron

U-Appel GB, uRadhakrishnan J, D'Agati VD. Isifo se-glomerular sesibini. Ku: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, ii-eds. Brenner kunye noMphathi weZintso. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2020: isahluko 32.

Isifo sika-Erkan E. Nephrotic. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. Umhla wama-21. IPhiladelphia, PA: Elsevier; 2020: isahlulo 545.