Cryoglobulinemia

I-Cryoglobulinemia bubukho beeproteni ezingaqhelekanga egazini. Ezi proteni ziyabanda kumaqondo obushushu abandayo.

I-Cryoglobulins ngamagciwane. Akukaziwa okwangoku ukuba kutheni zomelele okanye zifane nejeli kumaqondo obushushu asezantsi elebhu. Emzimbeni, ezi ntsholongwane zinokwenza amajoni omzimba anokubangela ukudumba kunye nokuvimba imithambo yegazi. Oku kubizwa ngokuba yi-cryoglobulinemic vasculitis. Oku kunokukhokelela kwiingxaki ezisusela kurhashalala lolusu ukuya ekusileleni kwezintso.

I-Cryoglobulinemia yinxalenye yeqela lezifo ezibangela ukonakala kunye nokudumba kwemithambo yegazi emzimbeni wonke (i-vasculitis). Zintathu iintlobo eziphambili zale meko. Ziqokelelwe ngokwamaqela e-antibody eveliswayo:

• Chwetheza I
• Uhlobo II
• Uhlobo lwe-III

Iindidi II no-III zikwabizwa ngokuba yi-cryoglobulinemia exutyiweyo.

Uhlobo I-cryoglobulinemia luhlala luhambelana nomhlaza wegazi okanye amajoni omzimba.

Iindidi II no-III zihlala zifunyanwa kubantu abanesifo esihlala ixesha elide (esingapheliyo) sokudumba, njengesifo sokuzimela okanye i-hepatitis C. Uninzi lwabantu abanoluhlobo II lwe-cryoglobulinemia banesifo se-hepatitis C esinganyangekiyo.

Ezinye iimeko ezinokuthi zihambelane ne-cryoglobulinemia zibandakanya:

• Ileukemia
• I-myeloma eninzi
• Iiprayimari ze-macroglobulinemia
• Irheumatoid Arthritis
• Inkqubo ye lupus erythematosus

Iimpawu ziya kwahluka, kuxhomekeka kuhlobo lwesifo onaso kunye namalungu abandakanyekayo. Iimpawu zingabandakanya:

• Iingxaki zokuphefumla
• Ukudinwa
• IGlomerulonephritis
• Intlungu edibeneyo
• Intlungu yezihlunu
• Iipurura
• Into kaRaynaud
• Ukufa kolusu
• Izilonda zolusu

Umboneleli wezempilo uya kwenza uvavanyo lomzimba. Uya kujongwa ukuba awunazimpawu zesibindi nokudumba.

Uvavanyo lwe-cryoglobulinemia lubandakanya:

• Gcwalisa ubalo lwegazi (CBC).
• Gcwalisa uvavanyo - amanani aya kuba sezantsi.
• Uvavanyo lweCryoglobulin- lunokubonisa ubukho beekryoglobulins. (Le yinkqubo entsonkothileyo yaselebhu ebandakanya amanyathelo amaninzi. Kubalulekile ukuba ilebhu eyenza uvavanyo iqhelene nenkqubo.)
• Ukuvavanywa kokusebenza kwesibindi-kunokuba phezulu ukuba isifo se-hepatitis C sikhona.
• I-rheumatoid factor-elungileyo kwiintlobo II kunye no-III.
• Ulusu lwe-biopsy-lunokubonisa ukudumba kwimithambo yegazi, i-vasculitis.
• Iprotein electrophoresis - igazi-inokubonisa iprotheni yomzimba engaqhelekanga.
• Uhlalutyo lomchamo-lunokubonisa igazi kumchamo ukuba ngaba izintso zichaphazele.

Olunye uvavanyo lunokubandakanya:

• I-Angiogram
• I-x-ray yesifuba
• I-ESR
• Uvavanyo lwe-Hepatitis C
• Uvavanyo lokuqhutywa kwemithambo, ukuba umntu unobuthathaka kwiingalo okanye emilenzeni

I-CRYOGLOBULINEMIA EXUBILEYO (IINDLELA II NO-III)

Iifom ezinobulali okanye eziphakathi ze-cryoglobulinemia zihlala zinokunyangwa ngokuthatha amanyathelo okujongana nesizathu esisisiseko.

Amayeza asebenza ngokuthe ngqo ngoku e-hepatitis C ayayisusa intsholongwane phantse kubo bonke abantu. Njengoko i-hepatitis C ihamba, ii-cryoglobulins ziya kunyamalala malunga nesiqingatha sabo bonke abantu kwiinyanga ezili-12 ezizayo. Umboneleli wakho uya kuqhubeka nokubeka iliso kwii-cryoglobulins emva konyango.

I-cryoglobulinemia vasculitis enamandla ibandakanya amalungu abalulekileyo okanye iindawo ezinkulu zolusu. Iphathwa nge-corticosteroids kunye namanye amayeza acinezela amajoni omzimba.

• I-Rituximab sisiyobisi esisebenzayo kwaye inobungozi obuncinci kunamanye amayeza.
• I-cyclophosphamide isetyenziswa kwiimeko ezisongela ubomi apho i-rituximab ingasebenzi okanye ingafumaneki. Eli yeza lalisetyenziswa rhoqo ngaphambili.
• Unyango olubizwa ngokuba yi-plasmapheresis luyasetyenziswa. Kule nkqubo, iplasma yegazi ithathwa ekujikelezeni kwegazi kwaye iiproteyini ze-cryoglobulin antibody ezingaqhelekanga ziyasuswa. Iplasma ithatha indawo yolwelo, iproteni, okanye iplasma enikelweyo.

TYPE I CRYOGLOBULINEMIA

Esi sifo senziwa ngumhlaza wegazi okanye amajoni omzimba anjenge-myeloma eninzi. Unyango lujolise kwiiseli zomhlaza ezingaqhelekanga ezivelisa i-cryoglobulin.

Uninzi lwexesha, i-cryoglobulinemia exubeneyo ayikhokeleli ekufeni. Umbono unokuba mpofu ukuba izintso ziyachaphazeleka.

Iingxaki zibandakanya:

• Ukopha kwindawo yokugaya (kunqabile)
• Isifo sentliziyo (kunqabile)
• Usulelo lwezilonda
• Ukungaphumeleli kwezintso
• Ukungaphumeleli kwesibindi
• Ukufa kolusu
• Ukufa

Fowunela umnikezeli wakho ukuba:

• Uphuhlisa iimpawu zekryoglobulinemia.
• Unesifo se-hepatitis C kwaye uvelise iimpawu ze-cryoglobulinemia.
• Unayo i-cryoglobulinemia kwaye uphuhlise iimpawu ezintsha okanye eziba mandundu.

Akukho sithintelo saziwayo kule meko.

• Ukuhlala kude namaqondo obushushu abandayo kunokuthintela iimpawu ezithile.
• Ukuvavanya kunye nokunyangwa kosulelo lwe-hepatitis C kuya kunciphisa umngcipheko.

• Cryoglobulinemia yeminwe
• Cryoglobulinemia - iminwe
• Iiseli zegazi

IPatterson ER, iWinters JL. IHemapheresis. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 37.

URoccatello D, uSaadoun D, ​​uRamos-Casals M, et al. Cryoglobulinaemia. UNat Rev Dis Primers. 2018; 4 (1): 11. IINKCUKACHA: 30072738 pubmed.ncbi.nlm.nih.gov/30072738/.

Ilitye JH. Isisu semithambo esine-vasculitis esincinci. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, ii-eds. Incwadi kaKelley kunye neFirestein yeRheumatology. Ngomhla we-10. IPhiladelphia, PA: Elsevier; Ngo-2017: isahluko 91.