Ukusilela kwefactor VII

Ukusilela kweFactor VII (sixhenxe) sisifo esibangelwa kukusilela kweprotein ebizwa ngokuba yi-factor VII egazini. Kukhokelela kwiingxaki ze-clotting yegazi (i-coagulation).

Xa usopha, uthotho lweempendulo zenzeka emzimbeni onceda amahlwili egazi. Le nkqubo ibizwa ngokuba yi-coagulation cascade. Ibandakanya iiproteni ezikhethekileyo ezibizwa ngokuba yi-coagulation, okanye izinto ezijiyisayo. Unokuba nethuba eliphezulu lokuphuma kwegazi kakhulu ukuba enye okanye ezingaphezulu kwezi zinto zilahlekile okanye azisebenzi njengoko kufanelekile.

Inqaku VII yenye yezinto ezijiyayo. Ukusilela kwento ye-VII ibaleka kwiintsapho (ezizuzwe njengelifa) kwaye kunqabile kakhulu. Bobabini abazali kufuneka babe nemfuza yokudlulisela ingxaki kubantwana babo. Imbali yosapho yokuphazamiseka kwegazi inokuba ngumngcipheko.

Ukusilela kwefactor VII kunokubangelwa yenye imeko okanye ukusetyenziswa kwamayeza athile. Oku kubizwa ngokuba kukusilela kwe-VII. Ingabangelwa ngu:

• I-vitamin K ephantsi (abanye abantwana bazalwa benesiphene se-vitamin K)
• Isifo esibi sesibindi
• Ukusetyenziswa kwamayeza athintela i-clotting (ii-anticoagulants ezifana ne-warfarin)

Iimpawu zinokubandakanya nayiphi na kwezi zinto zilandelayo:

• Ukopha kwimbumba yencindi
• Ukopha kumalungu
• Ukopha kwimisipha
• Ukukrala ngokulula
• Ukopha okuninzi kokuya exesheni
• Ukuphuma kweempumlo okungayeki ngokulula
• Umtya we-umbilical ukopha emva kokuzalwa

Uvavanyo olunokwenziwa lunokubandakanya:

• Ixesha lecandelo le-thromboplastin (PTT)
• Umsebenzi wePlasma factor VII
• Ixesha leprothrombin (PT)
• Ukuxubusha isifundo, uvavanyo olukhethekileyo lwe-PTT ukuqinisekisa ukusilela kwe-VII

Ukopha kunokulawulwa ngokufumana ukumithiswa kwegazi (IV) kwiplasma eqhelekileyo, kugxilwe kwi-factor VII, okanye kuveliswe ngokwemfuza (into ephindayo) VII.

Uya kudinga unyango rhoqo ngexesha leziqendu ezophayo kuba into VII ayihlali ixesha elide ngaphakathi emzimbeni. Uhlobo lwento VII ebizwa ngokuba yiNovoSeven nayo inokusetyenziswa.

Ukuba une-factor VII yokunqongophala ngenxa yokunqongophala kwe-vitamin K, ungayithatha le vithamin ngomlomo, ngokusebenzisa inaliti phantsi kolusu, okanye ngomthambo (ngaphakathi).

Ukuba unale ngxaki yokuphuma kwegazi, qiniseka ukuba:

• Xelela ababoneleli bakho bezempilo ngaphambi kokuba ube naluphi na uhlobo lwenkqubo, kubandakanya utyando kunye nomsebenzi wamazinyo.
• Xelela amalungu osapho lwakho kuba banokuba nengxaki efanayo kodwa abayazi okwangoku.

Ezi zixhobo zinokubonelela ngolwazi ngakumbi malunga nokusilela kweFactor VII:

• Isiseko seSizwe seHemophilia Foundation: Okunye ukusilela kweFactor- www.hemophilia.org/Bleeding-Disorder/Iindidi-ukukhupha igazi-Iingxaki/Okunye-Ifactor-Ukusilela
• Umbutho weSizwe weengxaki zoRare- rarediseases.org/rare-diseases/factor-vii-deficiency
• Isalathiso seKhaya leNLM yemfuzo - ghr.nlm.nih.gov/condition/factor-vii-defence

Ungalindela iziphumo ezilungileyo ngonyango olufanelekileyo.

Ukusilela kwilifa VII ukusilela yimeko yobomi bonke.

Imbonakalo yokunqongophala kwezinto ezifumanekayo VII ixhomekeke kwisizathu. Ukuba sibangelwa sisifo sesibindi, iziphumo zixhomekeke ekubeni isifo sakho sesibindi singanyangwa njani. Ukuthatha izongezo ze vithamin K kuya kunyanga ukusilela kwe vithamin K

Iingxaki zinokubandakanya:

• Ukopha kakhulu (ukopha)
• Ukubetha kwentliziyo okanye ezinye iingxaki zenkqubo yeemvakalelo ukusuka kwinkqubo yokopha embindini
• Iingxaki ezidibeneyo kwiimeko ezinzima xa ukuphuma kwegazi kwenzeka rhoqo

Fumana unyango olungxamisekileyo kwangoko ukuba wopha ngamandla, ungachazeki.

Akukho sithintelo saziwayo sokusilela kwilifa VII ukusilela. Xa ukunqongophala kukavithamini K kungunobangela, ukusebenzisa ivithamin K kunokunceda.

Ukusilela kweproconvertin; Ukusilela kwento yangaphandle; I-Serum prothrombin yokuguqula isantya sokunqongophala; Isifo sika-Alexander

• Ukubumba kwegazi
• Amahlwili egazi

UGailani D, Wheeler AP, Neff AT. Ukunqongophala kwezinto ezinqabileyo. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 137.

Iholo JE. I-Hemostasis kunye nokuqina kwegazi. KwiHolo yeJe, ed. Incwadi kaGuyton kunye neHolo yePhysical Physiology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 37.

Ragni MV. Ukuphazamiseka kwento eyophayo: ukungabikho kwento ekunqandeni. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 174.