I-CMV - gastroenteritis / colitis

I-CMV gastroenteritis / colitis kukudumba kwesisu okanye amathumbu ngenxa yosulelo kwi-cytomegalovirus.

Le ntsholongwane inokubangela:

• Usulelo lwemiphunga
• Usulelo ngasemva kweliso
• Usulelo lomntwana ngelixa esesibelekweni

I-Cytomegalovirus (CMV) yintsholongwane yohlobo lwe-herpes. Inxulumene nentsholongwane ebangela irhashalala.

Usulelo nge-CMV luxhaphake kakhulu. Isasazeka ngamathe, umchamo, amathontsi okuphefumla, ukudibana ngokwesondo, kunye notofelo-gazi. Uninzi lwabantu luvezwa ngaxa lithile, kodwa uninzi lwamaxesha, intsholongwane ivelisa kancinci okanye akukho zimpawu kubantu abasempilweni.

Usulelo olubi lweCMV lunokwenzeka kubantu abanamajoni omzimba abuthathaka ngenxa:

• UGawulayo
• Unyango lwe-Chemotherapy kumhlaza
• Ngexesha okanye emva komongo wethambo okanye ukufakelwa komzimba
• Ulcerative colitis okanye isifo seCrohn

Rhoqo, usulelo olubi lwe-CMV olubandakanya iphecana le-GI lwenzekile kubantu abanamajoni omzimba asempilweni.

Isifo seCMV esiswini sinokuchaphazela indawo enye okanye umzimba wonke. Izilonda zingenzeka kwi-esophagus, isisu, amathumbu amancinci, okanye ikholoni. Ezi zilonda zinxulunyaniswa neempawu ezinje:

• Intlungu zesisu
• Kunzima ukugwinya okanye iintlungu ngokuginya
• Isicaphucaphu
• Ukuhlanza

Xa amathumbu ebandakanyeka, izilonda zinokubangela:

• Intlungu zesisu
• Izitulo zegazi
• Urhudo
• Ifiva
• Ukuhla ukusinda

Usulelo olubi kakhulu lunokubangela ukopha emathunjini okanye umngxunya kudonga lwamathumbu (ukutyhoboza).

Uvavanyo olunokwenziwa lunokubandakanya:

• I-enema yeBarium
• IColonoscopy kunye ne-biopsy
• I-endoscopy ephezulu (i-EGD) ene-biopsy
• Isitulo senkcubeko yokulawula ezinye izizathu zosulelo
• I-GI ephezulu kunye namathumbu amancinci amancinci

Iimvavanyo zaselebhu ziya kwenziwa kwisampulu yethishu ethathwe esiswini sakho okanye emathunjini. Iimvavanyo, ezinje ngenkcubeko yesisu okanye yamathumbu emathunjini okanye i-biopsy, zichonga ukuba intsholongwane ikwisihlunu na.

Uvavanyo lwe-CMV serology lwenziwa ukukhangela ii-antibodies kwintsholongwane ye-CMV egazini lakho.

Olunye uvavanyo lwegazi olujonga ubukho kunye nenani lamasuntswana egciwane egazini nalo lunokwenziwa.

Unyango lwenzelwe ukulawula usulelo kunye nokunciphisa iimpawu.

Amayeza okulwa intsholongwane (amayeza antiviral) amiselwe. Amayeza anokunikwa ngomthambo (IV), ngamanye amaxesha ngomlomo, kangangeeveki ezininzi. Amayeza aqhelekileyo asetyenziswa yi-ganciclovir kunye ne-valganciclovir, kunye ne-foscarnet.

Ngamanye amaxesha, unyango lwexesha elide lunokufuneka. Iyeza elibizwa ngokuba yi-CMV hyperimmune globulin linokusetyenziswa xa ezinye iziyobisi zingasebenzi.

Amanye amayeza anokubandakanya:

• Iziyobisi ukuthintela okanye ukunciphisa urhudo
• Iipainkillers (iintlungu)

Izongezelelo zesondlo okanye isondlo esinikwa umthambo (IV) zinokusetyenziselwa ukunyanga ukulahleka kwemisipha ngenxa yesi sifo.

Kubantu abanamajoni omzimba asempilweni, iimpawu zihamba ngaphandle konyango kwiimeko ezininzi.

Iimpawu ziqatha ngakumbi kwabo banamajoni omzimba abuthathaka. Iziphumo zixhomekeke ekubeni unqongophele kangakanani amajoni omzimba kunye nosulelo lweCMV.

Abantu abanoGawulayo banokuba neziphumo ezibi kunalezo zinamajoni omzimba abuthathaka ngenxa yesinye isizathu.

Usulelo lwe-CMV luchaphazela umzimba uphela, nokuba ngaba zikhona iimpawu zesisu kuphela. Ukusebenza kakuhle komntu kuxhomekeke kwindlela asebenza ngayo amachiza antiviral.

Amachiza asetyenziselwa ukulwa intsholongwane anokubangela iziphumo ebezingalindelekanga. Uhlobo lwempembelelo yecala luxhomekeke kwichiza elithile elisetyenzisiweyo. Umzekelo, ichiza le-ganciclovir linokunciphisa inani leeseli ezimhlophe zegazi. Elinye ichiza, i-foscarnet, linokukhokelela kwiingxaki zezintso.

Fowunela umboneleli wakho wezempilo ukuba uneempawu zeCMV gastroenteritis / colitis.

Kukho umngcipheko omkhulu wosulelo lweCMV kubantu abafumana ukufakelwa komzimba kumnikeli oneCVV. Ukuthatha amachiza okulwa intsholongwane i-ganciclovir (i-cytovene) kunye ne-valganciclovir (iValcyte) ngomlomo ngaphambi kokuba utyando lunciphise ithuba lakho lokufumana usulelo olutsha okanye ukuvuselela usulelo oludala.

Abantu abanoGawulayo baphathwa ngokufanelekileyo ngonyango olusebenzayo lwe-antiretroviral kuncinci kakhulu ukuba bafumane usulelo lwe-CMV.

Icolitis - icytomegalovirus; Gastroenteritis - icytomegalovirus; Isifo seCVV esiswini

• I-anatomy yesisu
• Isisu kunye nesisu esiswini
• I-CMV (icytomegalovirus)

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IDupont HL, i-Okhuysen PC. Indlela eya kwisigulana esosulelayo sisifo se-enteric. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 267.

I-Larson AM, i-Issaka RB, i-Hockenbery DM. Ubunzima besisu kunye neengxaki ze-hepatic zelungu eliqinileyo kunye nokufakelwa kweseli yehematopoietic. Ku: UFeldman M, uFriedman LS, uBrandt LJ, ii-eds. Sleisenger kunye neFordtran's Gastrointestinal and Liver Disease. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 36.

UWilcox CM. Iziphumo zesisu sosulelo kwintsholongwane yabantu. Ku: UFeldman M, uFriedman LS, uBrandt LJ, ii-eds. Sleisenger kunye neFordtran's Gastrointestinal and Liver Disease. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 35.