Polyarteritis nodosa

I-Polyarteritis nodosa sisifo esinzulu somthambo wegazi. Imithambo encinci nophakathi iyadumba yonakaliswe.

Iimithambo yimithambo yegazi ephethe igazi eline-oksijini kwizitho kunye nezicubu. Unobangela we-polyarteritis nodosa awaziwa. Imeko yenzeka xa iiseli ezithile zomzimba zihlasela imithambo echaphazelekayo. Izicubu ezondliwa yimithambo echaphazelekayo azifumani oksijini kunye nokondla abakudingayo. Umonakalo wenzeka ngenxa yoko.

Abantu abadala ngakumbi kunabantwana bafumana esi sifo.

Abantu abane-hepatitis B esebenzayo okanye i-hepatitis C banokuphuhlisa esi sifo.

Iimpawu zibangelwa ngumonakalo kumalungu achaphazelekayo. Ulusu, amalunga, izihlunu, isisu, intliziyo, izintso, kunye nenkqubo ye-nervous zihlala zichaphazeleka.

Iimpawu zibandakanya:

• Intlungu zesisu
• Ukunciphisa ukutya
• Ukudinwa
• Ifiva
• Iintlungu ezidibeneyo
• Ubuhlungu bemisipha
• Ukuphulukana nobunzima ngabom
• Ubuthathaka

Ukuba imithambo ichaphazelekile, unokuba ndindisholo, iintlungu, ukutshisa kunye nokuba buthathaka. Ukonakala kwenkqubo ye-neva kunokubangela ukubetha okanye ukuxhuzula.

Akukho zilingo zelebhu zifumanekayo zokufumanisa isifo se-polyarteritis nodosa. Kukho ukuphazamiseka okunempawu ezifanayo ne-polyarthritis nodosa. Oku kwaziwa njenge "mimics."

Uya kuba novavanyo olupheleleyo lomzimba.

Uvavanyo lweLebhu olunokunceda ekwenzeni uxilongo kunye nokulawula ukulinganisa kubandakanya:

• Gcwalisa ubalo lwegazi (CBC) umahluko, i-creatinine, iimvavanyo ze-hepatitis B kunye no-C, kunye novavanyo lokuchama
• Ireyithi ye-erythrocyte sedimentation (ESR) okanye iprotein esebenzayo yeC (CRP)
• I-Serum protein electrophoresis, cryoglobulins
• Amanqanaba okuncedisa weSerum
• IArteriogram
• I-biopsy yethishu
• Olunye uvavanyo lwegazi luya kwenziwa ukulawula iimeko ezifanayo, ezinje nge-systemic lupus erythematosus (ANA) okanye i-granulomatosis ene-polyangiitis (ANCA)
• Uvavanyo lwe-HIV
• Cryoglobulins
• Amachiza alwa ne-phospholipid
• Iinkcubeko zegazi

Unyango lubandakanya amayeza acinezele ukudumba kunye nenkqubo yomzimba yokuzikhusela. Oku kunokubandakanya ii-steroids, ezinje nge-prednisone. Amayeza afanayo, afana ne-azathioprine, methotrexate okanye i-mycophenolate evumela ukunciphisa idosi ye-steroids zihlala zisetyenziswa ngokunjalo. Cyclophosphamide lisetyenziswa kwiimeko ezinzima.

Kwi-polyarteritis nodosa enxulumene ne-hepatitis, unyango lunokubandakanya iplasmapheresis kunye namayeza antiviral.

Unyango lwangoku kunye nee-steroids kunye nezinye iziyobisi ezicinezela amajoni omzimba (njenge-azathioprine okanye i-cyclophosphamide) zinokuphucula iimpawu kunye nethuba lokusinda ixesha elide.

Ezona ngxaki zixhaphakileyo zihlala zibandakanya izintso kunye namathumbu esiswini.

Ngaphandle konyango, umbono awukho kakuhle.

Iingxaki zinokubandakanya:

• Ukuhlaselwa yintliziyo
• I-necrosis yamathumbu emathunjini kunye nokugqobhoza
• Ukungaphumeleli kwezintso
• Ukubetha

Tsalela umnxeba umboneleli wakho ukuba ukhulisa iimpawu zesi sifo. Ukuchongwa kwangoko kunye nonyango kunokuphucula ithuba lesiphumo esihle.

Akukho sithintelo saziwayo. Nangona kunjalo, unyango lwakwangoko lunokuthintela umonakalo kunye neempawu ezithile.

Periarteritis nodosa; IPAN; Inkqubo ye-necrotizing vasculitis

• Microscopic polyarteritis 2
• Inkqubo yokujikeleza

Luqmani R, Awisat A. Polyarteritis nodosa kunye nokuphazamiseka okunxulumene noko. Ku: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, ii-eds. Incwadi yeFirestein kunye neKelley yeRheumatology. Ngomhla we-11. IPhiladelphia, PA: Elsevier; 2021: isahluko 95.

UPuéchal X, uPagnoux C, uBaron G, et al. Ukongeza i-azathioprine kwi-remission-induction glucocorticoids ye-eosinophilic granulomatosis kunye ne-polyangiitis (Churg-Strauss), microscopic polyangiitis, okanye i-polyarteritis nodosa ngaphandle kweemeko zokuxela: ityala elingahleliwe, elilawulwayo. Isifo samathambo Rheumatol. Ngo-2017; 69 (11): 2175-2186. IINKCUKACHA: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

IShanmugam VK. I-Vasculitis kunye nezinye ii-arteriopathies ezingaqhelekanga. Ku: Sidawy AN, Perler BA, ii-eds. Rutherford Uqhaqho lweMithambo kunye noNyango lwe-Endovascular. Umhla we-9. IPhiladelphia, PA: Elsevier; I-2019: isahluko 137.

Ilitye JH. Inkqubo ye-vasculitides. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 254.