Uvavanyo lweCombombs

Uvavanyo lweCoombs lujonga ii-antibodies ezinokuthi zincamathele kwiiseli zakho ezibomvu zegazi kwaye zibangele ukuba iiseli ezibomvu zegazi zife kwangoko.

Isampulu yegazi iyafuneka.

Akukho lungiselelo lukhethekileyo luyimfuneko kolu vavanyo.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukutyumza kancinci. Oku kuya kuhamba kungekudala.

Zimbini iintlobo zovavanyo lweCombombs:

• Ngqo
• Ngqo

Uvavanyo lwe-Coombs ngqo lusetyenziselwa ukukhangela ii-antibodies ezinamathele kumphezulu weeseli ezibomvu zegazi. Izifo ezininzi kunye neziyobisi zinokubangela ukuba oku kwenzeke. Ezi antibodies ngamanye amaxesha zitshabalalisa iiseli ezibomvu zegazi kwaye zibangele i-anemia. Umboneleli wakho wokhathalelo lwempilo unokucebisa olu vavanyo ukuba uneempawu okanye iimpawu ze-anemia okanye i-jaundice (ubumthubi besikhumba okanye amehlo).

Uvavanyo lwe-Coombs olungangqalanga lujonga ii-antibodies ezijikelezayo egazini. Ezi ntsholongwane zinokusebenza ngokuchasene neeseli ezibomvu zegazi. Olu vavanyo luhlala lwenziwa ukumisela ukuba unokufumana impendulo kutofelo-gazi.

Iziphumo eziqhelekileyo zibizwa ngokuba ziziphumo ezibi. Kuthetha ukuba bekungekho ukuhlangana kweeseli kwaye awunazo izilwa-buhlungu kwiiseli ezibomvu zegazi.

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Uvavanyo olungaqhelekanga (oluqinisekileyo) lweCoombs ngqo luthetha ukuba unezilwa ntsholongwane ezisebenza ngokuchasene neeseli ezibomvu zegazi. Oku kunokuba ngenxa:

• I-anemia ye-hemolytic ezenzekelayo
• I-lymphocytic leukemia engapheliyo okanye isifo esifanayo
• Isifo segazi kwiintsana ezibizwa ngokuba yi-erythroblastosis fetalis (ekwabizwa ngokuba sisifo sehemolytic sosana olusandul 'ukuzalwa)
• I-mononucleosis echaphazelekayo
• Usulelo lweMycoplasma
• Igcushuwa
• Inkqubo ye lupus erythematosus
• Ukusabela kotofelo-gazi, olufana nolunye ngenxa yeeyunithi zegazi ezingahambelani kakuhle

Iziphumo zovavanyo zinokungaqhelekanga ngaphandle kwesizathu esicacileyo, ngakumbi kubantu abadala.

Uvavanyo olungaqhelekanga (oluqinisekileyo) olungqalileyo lweeCombs lithetha ukuba unezilwa-buhlungu eziza kusebenza ngokuchasene neeseli ezibomvu zegazi umzimba wakho ozijonga njengezangaphandle. Oku kunokucebisa:

• I-Erythroblastosis fetalis
• Umdlalo wegazi ongahambelaniyo (xa usetyenziswa kwiibhanki zegazi)

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi elakhiweyo phantsi kolusu)
• Ukopha kakhulu
  
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Uvavanyo lwe-antiglobulin ngqo; Uvavanyo olungqalileyo lwe-antiglobulin; Anemia - haemolytic

I-Elghetany MT, i-Schexneider KI, i-Banki K.Ukuphazamiseka kwe-Erythrocytic. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 32.

UMichel M. Ukuzenzekelayo kunye ne-intravascular hemolytic anemias. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahl. 151.