Cwangcisa icandelo 3 (C3)

Ukugcwalisa i-C3 luvavanyo lwegazi olulinganisa umsebenzi weprotein ethile.

Le protein yinxalenye yenkqubo yokuncedisa. Inkqubo yokuncedisana liqela leeprotein eziphantse ezingama-60 ezikwi-plasma yegazi okanye kumphezulu weeseli ezithile. Iiproteni zisebenza kunye namajoni akho omzimba kwaye zidlala indima ukukhusela umzimba kwizifo, kunye nokususa iiseli ezifileyo kunye nezinto zangaphandle. Rhoqo, abantu banokufumana ilifa lokusilela kwezinye iiprotein ezincedisayo. Aba bantu bathambekele kusulelo oluthile okanye ukuphazamiseka komzimba.

Zilithoba iiprotheyini zokuncedisa. Babhalwe i-C1 nge-C9. Eli nqaku lichaza uvavanyo olulinganisa i-C3.

Igazi litsalwa emthanjeni. Rhoqo, umthambo ovela ngaphakathi kwengqiniba okanye umva wesandla uyasetyenziswa.

Inkqubo imi ngolu hlobo lulandelayo:

• Indawo icocwa nge-antiseptic.
• Umboneleli wezempilo usonga ibhanti yelastic ejikeleze ingalo ephezulu ukufaka uxinzelelo kuloo ndawo kwaye enze umthambo udumbe ligazi.
• Umboneleli ufaka inaliti ngobunono emthanjeni.
• Igazi liqokelela kwi-vial engena moya okanye ityhubhu eqhotyoshelwe kule naliti. Ibhanti e-elastic isuswe engalweni yakho.
• Nje ukuba igazi liqokelelwe, inaliti iyasuswa. Indawo yokubhoboza igqunyiwe ukunqanda ukopha.

Kwiintsana okanye kubantwana abancinci, isixhobo esibukhali esibizwa ngokuba yi-lancet sinokusetyenziselwa ukugqobhoza ulusu kunye nokwenza igazi.Igazi liqokelelwa kwityhubhu yeglasi encinci ebizwa ngokuba yipipette, okanye kwisilayidi okanye kumtya wovavanyo. Ibhandeji inokufakwa ngaphezulu kwendawo ukuba kukho ukopha.

Akukho lungiselelo lukhethekileyo luyafuneka.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye banokuziva ngathi batyhafile okanye batyhafile. Emva koko, kunokubakho ukuthotywa okuthile.

I-C3 kunye ne-C4 zezona zinto zixhaswa ngokulinganayo.

Uvavanyo lokuncedisa lungasetyenziselwa ukubeka esweni abantu abanesifo sokuzimela. Kuyenziwa ukubona ukuba unyango lweemeko zabo luyasebenza na. Xa inkqubo yokuncedisa ivuliwe ngexesha lokudumba, amanqanaba okuxhasa iiproteni anokuhla. Umzekelo, abantu abane-lupus erythematosus esebenzayo banokuba namanqanaba asezantsi kunalawo aqhelekileyo okuxhasa iiproteni ze-C3 kunye ne-C4.

Umsebenzi wokuncedisa uyahluka emzimbeni wonke. Umzekelo, kubantu abane-arthritis ye-rheumatoid, umsebenzi wokuncedisa egazini unokuba yinto eqhelekileyo okanye ephezulu kuneyona iqhelekileyo, kodwa isezantsi kakhulu kunesiqhelo kulwelo oluhlangeneyo.

Uvavanyo luyakwenziwa kwezi meko zilandelayo:

• Usulelo lomngundo
• I-gram septicemia
• Usulelo lwe-parasitic, njenge-malaria
• I-Paroxysmal nocturnal hemoglobinuria (PNH)
• Umothuko

Uluhlu oluqhelekileyo ngama-milligrams angama-88 ukuya kuma-201 kwidesilitha nganye (mg / dL) (0.88 ukuya ku-2.01 g / L).

Qaphela: Uluhlu lwamaxabiso aqhelekileyo luyahluka kancinci phakathi kweelebhu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Imizekelo engentla ibonisa imilinganiselo eqhelekileyo yeziphumo zolu vavanyo. Ezinye iilabhoratri zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo.

Ukonyusa imisebenzi yokuxhasa kunokubonwa ku:

• Umhlaza
• Ukudumba okwenziwa sisilonda sikabhobhosi

Ukuncipha komsebenzi wokuncedisa kunokubonwa ku:

• Usulelo lwebacteria (ngakumbi iNeisseria)
• Isibindi
• IGlomerulonephritis
• Hepatitis
• I-angioedema yelifa
• Ukhatywa kwezintso
• Lupus nephritis
• Ukungondleki
• Inkqubo ye lupus erythematosus
• Ukunqongophala kunqabile okuza kuzuzwa njengelifa
  
  

Iingozi ezinxulunyaniswa nokutsalwa kwegazi zincinci, kodwa zinokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Umncedisi we-cascade luthotho lwempendulo ezenzeka egazini. I-Cascade isebenza ngokuhambelana neeproteni. Isiphumo yeyunithi yohlaselo eyenza imingxunya kwimbumba yebacteria, ibabulale. I-C3 inamathela kwiibhaktheriya kwaye ibulale ngokuthe ngqo.

C3

• Uvavanyo lwegazi

IChernecky CC, iBerger BJ. Umxhasi weC3 (beta-1c-globulin) - serum. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 267-268.

IiHolers VM. Gqibezela kunye nabamkeli bayo: ukuqonda okutsha kwizifo zabantu. U-Annu Rev Immunol. Ngo-2014; 32: 433-459. IINKCUKACHA: 24499275 www.ncbi.nlm.nih.gov/pubmed/24499275.

IMassey HD, iMcPherson RA, iHuber SA, uJenny NS. Abalamli bokudumba: ukuncedisana. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 47.

I-Merle NS, iBandla SE, iFremeaux-Bacchi V, iRoumenina LT. Inkqubo yokugcwalisa icandelo le-I-molecular of activation and regulation. I-Immunol yangaphambili. Ngo-2015; 6: 262. IINKCUKACHA: 26082779 www.ncbi.nlm.nih.gov/pubmed/26082779.

IMerle NS, uNowa R, iHalbwachs-Mecarelli L, iFremeaux-Bacchi V, iRoumenina LT. Inkqubo yokugcwalisa icandelo II: indima ekukhuseleni. I-Immunol yangaphambili. Ngo-2015; 6: 257. IINKCUKACHA: 26074922 www.ncbi.nlm.nih.gov/pubmed/26074922.

UMorgan BP, uHarris CL. Ukuzalisa, ekujolise kuko kunyango lwezifo ezitshisayo kunye nokwehla. Nat Rev iziyobisi Discov. 2015; 14 (12): 857-877. IINKCUKACHA: 26493766 www.ncbi.nlm.nih.gov/pubmed/26493766.