Uvavanyo lomchamo we-PBG

I-Porphobilinogen (PBG) yenye yeentlobo ezininzi zeeporphyrins ezifumaneka emzimbeni wakho. Iiporphyrins zinceda ukwenza izinto ezininzi ezibalulekileyo emzimbeni. Enye yazo yihemoglobin, iproteni ekwiiseli ezibomvu zegazi ezithwala ioksijini egazini. Iiporphyrins zihlala zishiya umzimba wakho ngomchamo okanye ilindle. Ukuba le nkqubo ayenzeki, ii-porphyrins ezinjenge-PBG zinokwakha emzimbeni wakho.

Eli nqaku lichaza uvavanyo ukulinganisa isixa se-PBG kwisampulu yomchamo.

Emva kokubonelela ngesampulu yomchamo, iyavavanywa elebhu. Oku kubizwa ngokuba sisampulu yomchamo.

Ukuba kuyimfuneko, umboneleli wakho wezempilo unokucela ukuba uqokelele umchamo wakho ekhaya ngaphezulu kweeyure ezingama-24. Oku kubizwa ngokuba ngumzekelo weeyure ezingama-24. Umboneleli wakho uya kukuxelela ukuba ungayenza njani le nto. Landela imiyalelo ngokuchanekileyo.

Umboneleli wakho angakuxelela ukuba uyeke okwexeshana amayeza anokuchaphazela iziphumo zovavanyo. Qiniseka ukuba uxelela umboneleli wakho ngawo onke amayeza owathathayo. Oku kubandakanya:

• Amayeza okubulala iintsholongwane kunye neziyobisi ezichasene nokungunda
• Iziyobisi ezichasene noxinzelelo
• Iipilisi zokulawula inzala
• Amayeza eswekile
• Amayeza entlungu
• Amayeza okulala

Ungaze uyeke ukuthatha naliphi na iyeza ungakhange uqale uthethe nomboneleli wakho.

Olu vavanyo lubandakanya kuphela ukuchama okuqhelekileyo, kwaye akukho kungonwabi.

Olu vavanyo lunokwenziwa ukuba umboneleli wakho ukrokrela i-porphyria okanye esinye isifo esidibene nenqanaba le-PBG engaqhelekanga.

Kwisampulu yomchamo engahleliwe, iziphumo zovavanyo ezingalunganga zithathwa njengeziqhelekileyo.

Ukuba uvavanyo lwenziwe kwisampulu yomchamo weeyure ezingama-24, ixabiso eliqhelekileyo lingaphantsi kweemiligram ezi-4 ngeyure ezingama-24 (ii-micromoles ezili-18 ngeyure ezingama-24).

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba elonyukayo le-PBG kumchamo kunokuba ngenxa:

• Hepatitis
• Ityhefu yelothe
• Umhlaza wesibindi
• IPorphyria (iintlobo ezininzi)

Akukho bungozi kolu vavanyo.

Uvavanyo lwe-Porphobilinogen; Porphyria - umchamo; I-PBG

• Inkqubo yomchamo wamadoda

I-SJ epheleleyo, iWiley JS. I-Heme biosynthesis kunye nokuphazamiseka kwayo: i-porphyrias kunye ne-sideroblastic anemias. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 38.

URiley RS, uMcPherson RA. Uvavanyo olusisiseko lomchamo. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 28.