Uvavanyo lwe-Erythropoietin

Uvavanyo lwe-erythropoietin lilinganisa inani lehomoni ebizwa ngokuba yi-erythropoietin (EPO) egazini.

Ihommone uxelela iiseli ezitshisayo kumongo wethambo ukuba zenze iiseli ezibomvu zegazi ngakumbi. I-EPO yenziwa ziiseli kwizintso. Ezi seli zikhupha i-EPO engakumbi xa inqanaba leoksijini egazini liphantsi.

Isampulu yegazi iyafuneka.

Akukho lungiselelo lukhethekileyo luyimfuneko.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva ngathi batyhafile okanye batyhafile. Emva koko, kunokubakho ukuthotywa okuthile.

Olu vavanyo lunokusetyenziselwa ukunceda ukumisela unobangela we-anemia, i-polycythemia (ubalo oluphezulu lweeseli ezibomvu zegazi) okanye ezinye iingxaki zomongo wethambo.

Utshintsho kwiiseli ezibomvu zegazi luya kuchaphazela ukukhutshwa kwe-EPO. Umzekelo, abantu abane-anemia baneeseli ezibomvu ezimbalwa kakhulu, kungoko ke i-EPO eninzi iveliswayo.

Uluhlu oluqhelekileyo luyi-2.6 ukuya kwi-18.5 yezigidi ngeemililitha (mU / mL).

Imizekelo engentla yimilinganiselo eqhelekileyo yeziphumo zolu vavanyo. Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye ukuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yesiphumo sakho sovavanyo.

Ukonyuka kwenqanaba le-EPO kunokubangelwa yi-polycythemia yesibini. Oku kukuveliswa ngokugqithisileyo kweeseli ezibomvu zegazi ezenzeka ngokuphendula kwisiganeko esinjengeqondo eliphantsi leoksijini yegazi. Imeko inokwenzeka kwiindawo eziphakamileyo okanye, kunqabile, ngenxa yethumba ekhupha i-EPO.

Inqanaba le-EPO elisezantsi kuneliqhelekileyo linokubonwa kukusilela kwezintso okungapheliyo, i-anemia yesifo esinganyangekiyo, okanye i-polycythemia vera.

Iingozi ezinxulunyaniswa nokutsalwa kwegazi zincinci, kodwa zinokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Iseli erythropoietin; EPO

Bain BJ. I-peripheral yegazi smear. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 148.

UKaushansky K.Hematopoiesis kunye ne hematopoietic grow factor. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahl. 147.

UKremyanskaya M, Najfeld V, Mascarenhas J, Hoffman R.Iipolycythemias. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2018: isahluko 68.

UKumar V, u-Abbas AK, uAster JC. Iseli ebomvu yegazi kunye nokuphazamiseka kokopha. Ku: Kumar P, Clark M, ii-eds. Kumar kunye noClarke's Clinical Medicine. Umhla we-9. IPhiladelphia, PA: Elsevier; Ngo-2017: isahluko 14.