Uvavanyo lwegazi lweCortisol

Uvavanyo lwegazi lwe-cortisol lilinganisa inqanaba le-cortisol egazini. I-Cortisol yi-steroid (i-glucocorticoid okanye i-corticosteroid) i-hormone eveliswa yi-adrenal gland.

ICortisol inokulinganiswa kusetyenziswa umchamo okanye uvavanyo lwamathe.

Isampulu yegazi iyafuneka.

Ugqirha wakho uya kwenza uvavanyo ekuseni. Oku kubalulekile, kuba inqanaba le-cortisol liyahluka yonke imihla.

Unokucelwa ukuba ungenzi mthambo ngamandla kusuku olungaphambi kovavanyo.

Unokuxelelwa nokuba uyeke okwethutyana amayeza anokuchaphazela uvavanyo, kubandakanya:

• Iziyobisi ezichasene nokuhlutha
• Estrogen
• Izinto ezenziwe ngabantu (zokwenziwa) zeglucocorticoids, ezinje ngehydrocortisone, prednisone kunye ne-prednisolone
• Androgens

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukutyumza kancinci. Oku kuya kuhamba kungekudala.

Uvavanyo lwenziwe ukukhangela ukwanda okanye ukunciphisa imveliso ye-cortisol. ICortisol yiglucocorticoid (steroid) hormone ekhutshwe kwi-adrenal gland ekuphenduleni i-adrenocorticotropic hormone (ACTH). I-ACTH yincindi yedlala ephuma kwilungu lengqondo ebuchotsheni.

ICortisol ichaphazela iinkqubo ezahlukeneyo zomzimba. Idlala indima:

• Ukukhula kwamathambo
• Ulawulo lwexinzelelo lwegazi
• Umsebenzi we-immune system
• I-Metabolism yamafutha, iicarbohydrate, kunye neeprotein
• Umsebenzi wenkqubo yemithambo-luvo
• Impendulo yoxinzelelo

Izifo ezahlukileyo, ezinje ngeCushing syndrome kunye nesifo iAddison, zinokukhokelela kwimveliso yecortisol eninzi kakhulu okanye encinci. Ukulinganisa inqanaba legazi le-cortisol kunokunceda ukufumanisa imeko. Kukalinganiswa ukuvavanya ukuba isebenza njani i-pituitary kunye ne-adrenal gland.

Uvavanyo luhlala lwenziwa ngaphambi kweyure enye emva kwenaliti yeyeza ebizwa ngokuba yi-ACTH (cosyntropin). Eli candelo lovavanyo libizwa ngokuba luvavanyo lwe-ACTH. Luvavanyo olubalulekileyo olunceda ukukhangela ukusebenza kwamadlala ebubende kunye neadrenal.

Eminye imiqathango ekunga-odolwa kuyo uvavanyo ibandakanya:

• Ingxaki ye-adrenal, imeko esongela ubomi eyenzeka xa kungekho cortisol yaneleyo
• I-Sepsis, isifo apho umzimba uphendula ngokuqatha kwiintsholongwane okanye ezinye iintsholongwane
• Uxinzelelo lwegazi oluphantsi

Amaxabiso aqhelekileyo esampulu yegazi ethathwe nge-8 kusasa zi-5 ukuya kwi-25 mcg / dL okanye i-140 ukuya kwi-690 nmol / L.

Amaxabiso aqhelekileyo axhomekeke kwixesha losuku kunye nemeko yeklinikhi. Uluhlu oluqhelekileyo lunokwahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo. Thetha nogqirha wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba elingaphezulu kwesiqhelo linokubonisa:

• Isifo se-Cushing, apho i-pituitary gland yenza i-ACTH kakhulu ngenxa yokukhula okugqithisileyo kwe-pituitary gland okanye i-tumor kwi-pituitary gland
• I-Ectopic Cushing syndrome, apho ithumba ngaphandle kwamadlala ebuchopho okanye adrenal lenza kakhulu i-ACTH
• Ithumba le-adrenal gland evelisa kakhulu i-cortisol
• Uxinzelelo
• Ukugula kakhulu

Inqanaba elisezantsi kuneliqhelekileyo linokubonisa:

• Isifo iAddison, apho iincindi zamadlala zingavelisi ngokwaneleyo icortisol
• I-Hypopituitarism, apho i-pituitary gland ingabonakali uphawu lwe-adrenal gland ukuvelisa i-cortisol eyaneleyo
• Ukuncitshiswa kwento yesiqhelo yebhinqa okanye ye-adrenal ngamayeza e-glucocorticoid kubandakanya iipilisi, iikhrimu zolusu, i-eyedrops, inhalers, inaliti edibeneyo, ichemotherapy

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

I-serum cortisol

IChernecky CC, iBerger BJ. ICortisol - iplasma okanye i-serum. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 388-389.

Stewart PM, Newell-Price JDC. I-adrenal cortex. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 15.