Inqanaba leVitamin B12

Inqanaba levithamini B12 luvavanyo lwegazi olulinganisa ubuninzi bevithamini B12 egazini lakho.

Isampulu yegazi iyafuneka.

Akufuneki utye okanye usele malunga neeyure ezi-6 ukuya kwezi-8 ngaphambi kovavanyo.

Amayeza athile anokuchaphazela iziphumo zolu vavanyo. Umboneleli wakho wezempilo uya kukuxelela ukuba ngaba ufuna ukuyeka ukuthatha nawaphi na amayeza. SUKUYEKE nawaphi na amayeza ngaphambi kokuba uthethe nomboneleli wakho.

Amayeza anokuchaphazela iziphumo zovavanyo aquka:

• Colchicine
• Neomycin
• IPara-aminosalicylic acid
• IPhenytoin

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukukrala kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo luhlala lwenziwa xa ezinye iimvavanyo zegazi zibonisa imeko ebizwa ngokuba yi-megaloblastic anemia. I-anemia enobungozi luhlobo lwe-megaloblastic anemia ebangelwa kukungafuneki kakuhle kwe-vitamin B12. Oku kunokwenzeka xa isisu senza into engaphantsi komzimba kufuneka uyifunxe ngokufanelekileyo ivithamini B12.

Umboneleli wakho unokucebisa novavanyo lwe-vitamin B12 ukuba uneempawu ezithile zenkqubo ye-neva. Inqanaba eliphantsi le-B12 linokubangela ukuphazamiseka okanye ukubetha ezingalweni nasemilenzeni, ubuthathaka, kunye nelahleko yokulinganisa.

Eminye imiqathango enokwenziwa kuvavanyo ibandakanya:

• Ukudideka okukhulu ngesiquphe (delirium)
• Ukuphulukana nokusebenza kwengqondo (isifo sengqondo esixhalabisayo)
• Isifo sengqondo esixhalabisayo ngenxa yoonobangela bokubanga umzimba
• Ukungaqheleki kwamathambo, njenge-peripheral neuropathy

Amaxabiso aqhelekileyo zii-picograms eziyi-160 ukuya kwezi-950 ngeemililitha (pg / mL), okanye nge-118 ukuya kuma-701 ii-picomoles kwilitha nganye (pmol / L).

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho malunga neziphumo zovavanyo lwakho ezithile zithetha ntoni.

Ixabiso elingaphantsi kwe-160 pg / mL (118 pmol / L) luphawu olunokubakho lokusilela kwe-vitamin B12. Abantu abanesiphene banokubakho okanye bakhulise iimpawu.

Abantu abadala abanevithamini B12 yenqanaba elingaphantsi kwe-100 pg / mL (74 pmol / L) banokuba neempawu. Ukusilela kufuneka kuqinisekiswe ngokujonga inqanaba lezinto ezisegazini ezibizwa ngokuba yi-methylmalonic acid. Inqanaba eliphezulu libonisa ukusilela kwe-B12 yokwenyani.

Izizathu zokunqongophala kwe-vitamin B12 zibandakanya:

• Ayonelanga i-vitamin B12 kukutya (kunqabile, ngaphandle kokutya okungqongqo kwemifuno)
• Izifo ezibangela i-malabsorption (umzekelo, isifo se-celiac kunye nesifo se-Crohn)
• Ukunqongophala kwento engenayo, iprotein enceda amathumbu afumane ivithamini B12
• Ngaphezulu kwemveliso eqhelekileyo yobushushu (umzekelo, ngehyperthyroidism)
• Ukukhulelwa

Ukunyuka kwenqanaba levithamini B12 akuqhelekanga. Ngokwesiqhelo, i-vitamin B12 egqithisileyo iyasuswa kumchamo.

Iimeko ezinokunyusa inqanaba le-B12 zibandakanya:

• Isifo sesibindi (njenge-cirrhosis okanye i-hepatitis)
• Iingxaki ze-Myeloproliferative (umzekelo, i-polycythemia vera kunye ne-leukemia engapheliyo)

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye nakwelinye icala lomzimba liye kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi elakhiweyo phantsi kolusu)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Uvavanyo lweCobalamin; I-anemia enobunzima - inqanaba levithamini B12

IMarcogliese AN, ewe DL. Izixhobo ze-hematologist: Amagqabantshintshi otolikayo kunye namaxabiso akhethiweyo esalathiso seentsana, abantwana kunye nabantu abadala. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 162.

UMason JB, iBooth SL. Iivithamini, ukulandelela iiminerali, kunye nezinye izinto ezincinci. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 205.