Iprogesterone ye-17-OH

Iprogesterone ye-17-OH luvavanyo lwegazi olulinganisa inani le-17-OH progesterone. Le hormone iveliswa ngamadlala adrenal kunye namadlala esini.

Isampulu yegazi iyafuneka. Uninzi lwexesha, igazi litsalwa kumthambo ngaphakathi kwengqiniba okanye ngasemva kwesandla.

Kwiintsana okanye abantwana abancinci, isixhobo esibukhali esibizwa ngokuba yi-lancet sinokusetyenziselwa ukugqobhoza ulusu.

• Igazi liqokelela kwityhubhu yeglasi encinci ebizwa ngokuba yipipette, okanye kwisilayidi okanye kumtya wovavanyo.
• Ibhandeji ibekwa phezu kwendawo ukunqanda ukopha.

Amayeza amaninzi anokuphazamisa iziphumo zovavanyo lwegazi.

• Umboneleli wakho wokhathalelo lwempilo uya kukuxelela ukuba ngaba ufuna ukuyeka ukuthatha nawaphi na amayeza phambi kokuba wenze olu vavanyo.
• Sukuyeka okanye ukutshintsha amayeza akho ungakhange uthethe nomboneleli wakho kuqala.

Unokuziva iintlungu okanye ulwamvila xa kufakwa inaliti. Unokuziva ubethwa sisiza emva kokuba kuthathwe igazi.

Ukusetyenziswa okuphambili kolu vavanyo kukujonga iintsana kwisifo esasifumana kwilifa esichaphazela i-adrenal gland, ebizwa ngokuba yi-congenital adrenal hyperplasia (CAH). Ihlala isenziwa kwiintsana ezizalwe zinamalungu angasese angaphandle angakhange abonakale kakuhle afana nawenkwenkwe okanye awentombazana.

Olu vavanyo lukwasetyenziselwa ukuchonga abantu abaphuhlisa iimpawu ze-CAH kamva ebomini, imeko ebizwa ngokuba yi-nonclassical adrenal hyperplasia.

Umboneleli unokucebisa olu vavanyo kubafazi okanye amantombazana aneempawu zobudoda ezinje:

• Ukukhula okungaphezulu kweenwele kwiindawo apho amadoda amadala akhula khona
• Ilizwi elinzulu okanye ukwanda kobunzima bemisipha
• Ukungabikho kwamaxesha
• Ukungachumi

Amaxabiso aqhelekileyo nangaqhelekanga kwiintsana ezizelwe zinesisindo sokuzalwa esisezantsi. Ngokubanzi, iziphumo eziqhelekileyo zezi zilandelayo:

• Iintsana ezingaphezu kweeyure ezingama-24 ubudala-ngaphantsi kwama-400 ukuya kuma-600 ama-nanograms kwi-deciliter nganye (ng / dL) okanye i-12.12 ukuya kwi-18.18 i-nanomoles ilitha nganye (nmol / L)
• Abantwana ngaphambi kokufikisa malunga ne-100 ng / dL okanye i-3.03 nmol / L
• Abantu abadala-bangaphantsi kwama-200 ng / dL okanye 6.06 nmol / L

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Thetha nomboneleli wakho malunga nentsingiselo yeziphumo zakho zovavanyo.

Imizekelo engentla ibonisa imilinganiselo eqhelekileyo yeziphumo zolu vavanyo. Ezinye iilabhoratri zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo.

Inqanaba eliphezulu le-17-OH progesterone inokubangelwa:

• Amathumba le ndlala adrenal
• I-adrenal hyperplasia yaso (CAH)

Kwiintsana ezine-CAH, inqanaba le-17-OHP lisusela kwi-2,000 ukuya kwi-40,000 ng / dL okanye i-60.6 ukuya kwi-1212 nmol / L. Kubantu abadala, inqanaba elingaphezulu kwe-200 ng / dL okanye i-6.06 nmol / L inokuba ngenxa ye-nonclassical adrenal hyperplasia.

Umboneleli wakho unokucebisa uvavanyo lwe-ACTH ukuba inqanaba leprogesterone le-17-OH liphakathi kwama-200 ukuya kuma-800 ng / dL okanye i-6.06 ukuya kwi-24.24 nmol / L.

17-hydroxyprogesterone; Iprogesterone-17-OH

UGuber HA, uFarag AF. Uvavanyo lomsebenzi we-endocrine. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 24.

Rey RA, Josso N.Ukuchongwa kunye nokunyangwa kokuphazamiseka kuphuhliso lwezesondo. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, ii-eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 119.

IPc emhlophe. I-hyperplasia ye-adrenal ye-congenital kunye nokuphazamiseka okunxulumene noko. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. Umhla wama-21. IPhiladelphia, PA: Elsevier; 2020: isahluko 594.