Uvavanyo lwegazi lwe-Alpha-1 antitrypsin

I-Alpha-1 antitrypsin (AAT) luvavanyo lwaselebhu ukulinganisa inani le-AAT egazini lakho. Uvavanyo luyenziwa kwakhona ukujonga iifom ezingaqhelekanga ze-AAT.

Isampulu yegazi iyafuneka.

Akukho lungiselelo lukhethekileyo.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukukrala kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo luncedo ekuchongeni uhlobo olunqabileyo lwe-emphysema kubantu abadala kunye nefom enqabileyo yesifo sesibindi (i-cirrhosis) ebantwaneni nakubantu abadala ebangelwa kukusilela kwe-AAT. Ukusilela kwe-AAT kudluliswa kwiintsapho. Imeko ibangela ukuba isibindi senze i-AAT encinci, iprotein ekhusela imiphunga kunye nesibindi kumonakalo.

Wonke umntu uneekopi ezimbini zofuzo ezenza i-AAT. Abantu abaneekopi ezimbini ezingaqhelekanga zofuzo banesifo esibi kakhulu kunye namanqanaba egazi asezantsi.

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yeziphumo zakho zovavanyo.

Inqanaba elisezantsi kuneliqhelekileyo le-AAT linokudityaniswa:

• Ukonakaliswa kweendlela ezinkulu zomoya kwimiphunga (i-bronchiectasis)
• Ukuqhekeka kwesibindi (i-cirrhosis)
• Isifo esinganyangekiyo semiphunga (COPD)
• Amathumba wesibindi
• Ukutyheli kolusu kunye namehlo ngenxa yokuthintela ukuhamba kwenyongo
• Uxinzelelo lwegazi oluphezulu emthanjeni omkhulu kukhokelela kwisibindi (uxinzelelo lwegazi portal)

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye, kwaye ukusuka kwelinye icala lomzimba ukuya kwelinye. Ukuthatha igazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Uvavanyo lwe-A1AT

IChernecky CC, iBerger BJ. UAlfa₁i-antitrypsin-serum. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 121-122.

UWinnie GB, iBoas SR. a₁ -I-Antitrypsin defence kunye ne-emphysema. Ku: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, ii-eds. Incwadi kaNelson yeNcwadi yePediatrics. Umhla wama-21. IPhiladelphia, PA: Elsevier; 2020: isahluko 421.