Erlotinib

Umxholo

• Ngaphambi kokuba uthathe i-erlotinib,
• I-Erlotinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Erlotinib isetyenziselwa ukunyanga iintlobo ezithile zomhlaza wesifo semiphunga ongekho mncinci osasazeke kwizicubu ezikufutshane okanye kwamanye amalungu omzimba kwizigulana esele zinyangwe okungenani elinye iyeza lonyango kwaye aluzange lubengcono. I-Erlotinib ikwasetyenziswa ngokudibanisa nelinye iyeza (gemcitabine [Gemzar]) ukunyanga umhlaza wepancreatic osasazeke kwizicwili ezikufutshane okanye kwamanye amalungu omzimba kwaye awunakunyangwa ngoqhaqho. U-Erlotinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

U-Erlotinib uza njengepilisi ukuba ayithathe ngomlomo. Ihlala ithathwa ngaphandle kwesisu kanye ngemini, ubuncinci iyure enye ngaphambi okanye iiyure ezi-2 emva kokutya okanye ukutya. Thatha i-erlotinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-erlotinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ugqirha wakho unokunciphisa idosi yakho ye-erlotinib ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-erlotinib nokuba uziva uphilile. Sukuyeka ukuthatha i-erlotinib ungakhange uthethe nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-erlotinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-erlotinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-erlotinib Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: angiogenesis inhibitors ezinje nge-bevacizumab (Avastin); ii-anticoagulants ('igazi elincinci)' njengewarfarin (Coumadin); ii-antifungals ezithile ezinje nge-itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); I-boceprevir (iVictrelis); carbamazepine (Tegretol); ciprofloxacin (Cipro, Proquin XR); i-clarithromycin (i-Biaxin); ikhonkco (Vaprisol); I-HIV protease inhibitors efana ne-atazanavir (Reyataz), indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), kunye ne-saquinavir (Fortovase, Invirase); H₂ iibhloko ezifana ne-cimetidine (Tagamet), i-famotidine (i-Pepcid), i-nizatidine (i-Axid), kunye ne-ranitidine (i-Zantac); amayeza amabala afana ne-benzoyl peroxide (e-Epiduo, eBenzaClin, eBenzamycin, nabanye); midazolam (iVesi): nefazodone; iziyobisi ezichasayo (ii-NSAID) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); i-steroids yomlomo efana ne-dexamethasone (i-Decadron, i-Dexone), i-methylprednisolone (Medrol), kunye ne-prednisone (Deltasone); phenobarbital (iLuminal, iSolfoton); phenytoin (Dilantin); Iiproton pump inhibitors ezifana ne-esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), kunye ne-rabeprazole (AcipHex); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane); irifapentine; amayeza eteksi kumhlaza njenge-docetaxel (iTaxotere) kunye ne-paclitaxel (i-Abraxane, iTaxol); telithromycin (Ketek); teriflunomide (Aubagio); kunye ne-troleandomycin (TAO) (ayifumaneki e-U.S. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-erlotinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• ukuba uthatha ii-antacids, zithathe iiyure ezininzi ngaphambi okanye kwiiyure ezininzi emva kokuba uthathe i-erlotinib.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba uyanyangwa okanye usandula kunyangwa ngechemotherapy okanye unyango ngemitha (unyango lomhlaza olusebenzisa amaza amasuntswana amandla ukubulala iiseli zomhlaza). Xelela ugqirha wakho ukuba ukhe unesifo semiphunga okanye usulelo, izilonda zesisu, isifo esingafaniyo (imeko apho iipakethi ezingaqhelekanga zenzeka emathunjini amakhulu kwaye zinokutsha), okanye isibindi okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-erlotinib kwaye ubuncinci inyanga e-1 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa. Ukuba ukhulelwe, biza ugqirha wakho ngokukhawuleza. U-Erlotinib unokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngexesha lonyango lwakho kunye ne-erlotinib kunye nokuya kuthi ga kwiiveki ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-erlotinib.
• xelela ugqirha wakho ukuba usebenzisa iimveliso zecuba. Ukutshaya icuba kunokunciphisa ukusebenza kweli yeza.
• cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko okanye ixesha elide kunye nokunxiba umnqwazi, ezinye iimpahla zokuzikhusela, iiglasi zelanga kunye nescreen selanga. Khetha i-sunscreen ene-sun protection factor (SPF) ye-15 ubuncinci kwaye ine-zinc oxide okanye i-titanium dioxide. Ukubonakaliswa kukukhanya kwelanga kwandisa umngcipheko wokuba uya kuphuhlisa irhashalala ngexesha lonyango kunye ne-erlotinib.
• Kuya kufuneka uyazi ukuba i-erlotinib inokubangela irhashalala kunye nezinye iingxaki zolusu. Ukukhusela ulusu lwakho, sebenzisa amafutha okuthambisa angenabutywala, uhlambe isikhumba sakho ngesepha epholileyo, kwaye ususe izinto zokuthambisa ngesicoci esincinci.

Kuphephe ukutya iidiliya kunye nokusela ijusi yegrapefruit ngelixa uthatha eli yeza.

Ukuthintela urhudo olunokuthi lubangelwe yi-erlotinib, sela iincindi ezincinci zolwelo njengesiselo esingenashukela kwezemidlalo rhoqo ngalo lonke usuku, yitya ukutya okuthambileyo okufana nokuqhekeza kunye ne-toast, kunye nokutya ukutya okunezipayisi.

Thatha idosi elandelayo ngexesha lakho eliqhelekileyo ngosuku olulandelayo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Erlotinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• Ukuphelelwa ngumdla wokutya
• isicaphucaphu
• ukugabha
• isilungulela
• irhasi
• ukuqhina
• izilonda zomlomo
• ukuhla ukusinda
• ukudinwa kakhulu
• intloko ebuhlungu
• iintlungu zethambo okanye izihlunu
• ukudakumba
• ixhala
• Ukuba ndindisholo, ukutshisa, okanye ukubetha kwezandla okanye kweenyawo
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ubumnyama besikhumba
• ukulahleka kweenwele
• utshintsho kwinkangeleko yeenwele kunye neenzipho

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• irhashalala (inokubonakala ngathi ngamabala kwaye inokuchaphazela ulusu ebusweni, esifubeni ngaphezulu, okanye ngasemva)
• ukudumba, ukuxobuka, ukoma okanye ulusu
• ukurhawuzelela, ukuthamba okanye ukutshisa ulusu
• ukuqhawukelwa ngumphefumlo
• ukukhohlela
• umkhuhlane okanye ukubanda
• ukukhula kweenkophe ngaphakathi kwenkophe
• iintlungu ezinzima zesisu
• bomile, bomvu, buhlungu, ziinyembezi, okanye amehlo akhathazekile
• ukungaboni kakuhle
• ubuntununtunu bamehlo ekukhanyeni
• iintlungu esifubeni okanye uxinzelelo
• iintlungu ezingalweni, entanyeni, okanye kumqolo ongasentla
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• intetho ecothayo okanye enzima
• isiyezi okanye ukudinwa
• ubuthathaka okanye ukuba ndindisholo kwengalo okanye umlenze
• ukugruzuka okanye ukopha okungaqhelekanga
• mnyama kunye nokulinda okanye izitulo ezinegazi
• ukugabha okunegazi okanye okujongeka njengendawo yekofu
• Amehlo atshonile
• umlomo owomileyo
• ukuncipha kokuchama
• umchamo omnyama
• isikhumba esiluthuthu okanye esimthubi
• ubomvu, ukufudumala, iintlungu, ukuthamba, okanye ukudumba emlenzeni omnye

I-Erlotinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• urhudo
• irhashalala

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-erlotinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Tarceva^®