Inaliti yeRituximab

Umxholo

• Ngaphambi kokufumana imveliso yenalitiximab,
• Iimveliso zenaliti ye-Rituximab zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

Inaliti ye-Rituximab, inaliti ye-rituximab-abbs, kunye nenaliti ye-rituximab-pvvr ngamayeza e-biologic (amayeza enziwe kwizinto eziphilayo). Inaliti ye-Biosimilar rituximab-abbs kunye nenaliti ye-rituximab-pvvr ifana kakhulu nenaliti ye-rituximab kwaye isebenza ngendlela efanayo nenaliti ye-rituximab emzimbeni. Ke ngoko, igama elithi iimveliso ze-rituximab ziya kusetyenziswa ukumela la mayeza kule ngxoxo.

Unokufumana impendulo enzulu ngelixa ufumana okanye kwiiyure ezingama-24 emva kokufumana idosi yemveliso yenaliti ye-rituximab. Ezi mpendulo zihlala zenzeka ngexesha ledosi yokuqala yemveliso yenaliti ye-rituximab kwaye inokubangela ukufa. Uya kufumana idosi nganye yemveliso yenaliti ye-rituximab kwiziko lonyango, kwaye ugqirha okanye umongikazi uya kukujonga ngononophelo ngelixa ufumana amayeza. Uya kufumana amayeza athile ukunceda ukuthintela ukusabela okungafunekiyo ngaphambi kokuba ufumane idosi nganye yemveliso yenaliti ye-rituximab. Tshela ugqirha wakho ukuba wakhe waphendula kwimveliso ye-rituximab okanye ukuba unayo okanye wakha wabetha ngentliziyo ngendlela engaqhelekanga, iintlungu esifubeni, ezinye iingxaki zentliziyo, okanye iingxaki zemiphunga. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha wakho okanye umboneleli wezempilo kwangoko: irhashalala; ukurhawuzelela; ukudumba kwemilebe, ulwimi, okanye umqala; ubunzima bokuphefumla okanye ukugwinya; isiyezi; isiqaqa; ukuphefumla kancinci, ukuvutha; intloko ebuhlungu; ukubetha okanye ukubetha kwentliziyo okungaqhelekanga; ukukhawuleza okanye ubuthathaka; ulusu olukhanyayo okanye oluhlaza; iintlungu esifubeni ezinokuthi zisasazeke kwamanye amalungu omzimba aphezulu; ubuthathaka; okanye ukubila okunzima.

Iimveliso zenaliti ye-Rituximab zibangele ulusu, kunye nokusabela okusongela ubomi. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, xelela ugqirha ngoko nangoko: izilonda ezibuhlungu okanye izilonda kulusu, kwimilebe okanye emlonyeni; amadyungudyungu; irhashalala; okanye uxobuka ulusu.

Usenokuba bosulelwe yi-hepatitis B (intsholongwane esosulela isibindi kwaye inokubangela ukonakala kwesibindi) kodwa ungabinazo iimpawu zesifo. Kule meko, ukufumana imveliso yenaliti ye-rituximab kunokunyusa umngcipheko wokuba usulelo lwakho lube mandundu ngakumbi okanye lusongele ubomi kwaye uya kuba neempawu. Tshela ugqirha wakho ukuba ukhe wosulelekile, kubandakanya usulelo lwentsholongwane ye-hepatitis B. Ugqirha wakho uya kuyalela uvavanyo lwegazi ukuze abone ukuba unesifo se-hepatitis B esingasebenziyo. Ukuba kukho imfuneko, ugqirha unokukunika amayeza ukunyanga olu sulelo ngaphambi nangexesha lonyango lwakho ngemveliso yenaliti ye-rituximab. Ugqirha wakho uya kukujonga esweni usulelo lwe-hepatitis B ngexesha kunye neenyanga ezimbalwa emva konyango lwakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva konyango lwakho, tsalela umnxeba kwangoko: ukudinwa okugqithisileyo, ukutyheli kwesikhumba okanye amehlo, ukuphelelwa ngumdla, isicaphucaphu okanye ukugabha, iintlungu zemisipha, iintlungu zesisu, okanye umchamo omnyama.

Abanye abantu abafumene imveliso yenaliti ye-rituximab bakhula ngokuqhubekayo ne-leukoencephalopathy (PML; isifo esinqabileyo sobuchopho esinganyangekiyo, esinokuthintelwa, okanye esinganyangekiyo esihlala sibangela ukufa okanye ukukhubazeka kakhulu) ngexesha okanye emva konyango lwabo. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha wakho ngokukhawuleza: utshintsho olutsha okanye olukhawulezileyo ekucingeni nasekudidekeni; ubunzima bokuthetha okanye ukuhamba; ukulahleka kwemali eseleyo; ukuphelelwa ngamandla; utshintsho olutsha okanye olukhawulezileyo kumbono; okanye naziphi na ezinye iimpawu ezingaqhelekanga ezithi zivele ngesiquphe.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwimveliso yenaliti ye-rituximab.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seMithi) xa uqala unyango ngenaliti ye-rituximab kwaye ngalo lonke ixesha ufumana iyeza. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nemingcipheko yokusebenzisa imveliso yenaliti ye-rituximab.

Iimveliso zenaliti ye-Rituximab zisetyenziswa zodwa okanye namanye amayeza ukunyanga iintlobo ezahlukeneyo ze-non-Hodgkin's lymphoma (NHL; uhlobo lomhlaza oqala kuhlobo lweeseli ezimhlophe zegazi zihlala zilwa nosulelo). Iimveliso zenaliti yeRituximab zikwasetyenziswa namanye amayeza ukunyanga i-lymphocytic leukemia (CLL; uhlobo lomhlaza weeseli ezimhlophe zegazi). Inaliti ye-Rituximab (i-Rituxan) ikwasetyenziswa kunye ne-methotrexate (i-Otrexup, i-Rasuvo, i-Xatmep, abanye) ukunyanga iimpawu zesifo samathambo (RA; imeko apho umzimba uhlasela amalungu ayo, ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) kubantu abadala abasele bephethwe ngohlobo oluthile lwamayeza abizwa ngokuba yi-tumor necrosis factor (TNF) inhibitor. Inaliti ye-Rituximab (i-Rituxan, i-Ruxience) ikwasetyenziswa nakubantu abadala nakwiminyaka emi-2 nangaphezulu kunye namanye amayeza ukunyanga i-granulomatosis nge-polyangiitis (Wegener's Granulomatosis) kunye ne-microscopic polyangiitis, eyimeko apho umzimba uhlasela imithambo yayo kunye nezinye imithambo yegazi, ebangela ukonakala kumalungu, anjengentliziyo nemiphunga. Inaliti ye-Rituximab (i-Rituxan) isetyenziselwa ukunyanga i-pemphigus vulgaris (imeko ebangela iblisters ezibuhlungu kulusu kunye nokufaka umlomo, impumlo, umqala kunye nezitho zangasese). Iimveliso zenaliti ye-Rituximab zikudidi lwamayeza abizwa ngokuba ngamachiza omzimba. Banyanga iintlobo ezahlukeneyo ze-NHL kunye ne-CLL ngokubulala iiseli zomhlaza. Ezinye iimveliso zenaliti ye-rituximab zikwanyanga i-rheumatoid arthritis, i-granulomatosis ene-polyangiitis, i-microscopic polyangiitis, kunye ne-pemphigus vulgaris ngokuthintela ukusebenza kwenxalenye yamajoni omzimba onokonakalisa amalungu, imithambo kunye neminye imithambo yegazi.

Iimveliso zenaliti ye-Rituximab ziza njengesisombululo (ulwelo) ukuze ifakwe kwi-vein. Iimveliso zenaliti yeRituximab zilawulwa ngugqirha okanye ngumongikazi kwiofisi yezonyango okanye kwiziko lokumnika. Ishedyuli yakho yokulinganisa iya kuxhomekeka kwimeko onayo, amanye amayeza owasebenzisayo, kunye nendlela ophendula ngayo emzimbeni wakho kunyango.

Iimveliso zenaliti ye-Rituximab kufuneka zinikwe kancinci emthanjeni. Kungathatha iiyure ezininzi okanye ixesha elide ukufumana idosi yakho yokuqala yemveliso yenaliti ye-rituximab, ke kuya kufuneka ucwangcise ukuchitha ixesha elininzi emini kwiofisi yezonyango okanye kwiziko lokumiliselwa emva kwedosi yokuqala, unokufumana imveliso yenaliti ye-rituximab ngokukhawuleza , kuxhomekeke kwindlela ophendula ngayo kunyango.

Unokufumana iimpawu ezinje ngomkhuhlane, ukugungqa ukugodola, ukudinwa, intloko ebuhlungu, okanye isicaphucaphu ngelixa ufumana idosi yemveliso ye-rituximab, ngakumbi idosi yokuqala. Tshela ugqirha wakho okanye umboneleli wezempilo ukuba ufumana ezi mpawu ngelixa ufumana iyeza lakho. Ugqirha wakho unokuyalela amanye amayeza ukunceda ukuthintela okanye ukunciphisa ezi mpawu. Ugqirha wakho uya kukuxelela ukuba uthathe la mayeza ngaphambi kokuba ufumane idosi nganye yemveliso ye-rituximab.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana imveliso yenalitiximab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-rituximab, i-rituximab-abbs, i-rituximab-pvvr, nawaphi na amanye amayeza, okanye naziphi na izithako kwimveliso yenaliti ye-rituximab. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: adalimumab (Humira); isatifikethi (Cimzia); etanercept (Enbrel); igolimumab (iSimponi); infliximab (Remicade); amanye amayeza e-rheumatoid arthritis; kunye namayeza acinezela amajoni omzimba anje nge-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune, Torisel), kunye ne-tacrolimus (Envarsus, Prograf). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unayo nayiphi na imiqathango ekhankanywe kwicandelo LESILUMKISO ELIBALULEKILEYO kwaye ukuba ubukhe wanesifo sokudumba kwesibindi kohlobo C okanye ezinye iintsholongwane ezinjengerhashalala, iherpes (intsholongwane enokubangela izilonda ezibandayo okanye ukuqhambuka kwamadyunguza kwilungu lobufazi. indawo), i-shingles, intsholongwane ye-West Nile (intsholongwane esasazeka ngokulunywa yingcongconi kwaye inokubangela iimpawu ezibi), i-parvovirus B19 (isifo sesihlanu; intsholongwane eqhelekileyo ebantwaneni edla ngokubangela iingxaki ezinkulu kwabanye abantu abadala), okanye i-cytomegalovirus (a intsholongwane eqhelekileyo edla ngokubangela iimpawu ezibi ebantwini abathe babuthathaka amajoni omzimba okanye abosulelekileyo xa bezalwa), okanye isifo sezintso.Xelela ugqirha wakho ukuba unalo naluphi na uhlobo losulelo ngoku okanye ukuba unayo okanye wakhe wanesifo esingazukuhamba okanye usulelo oluza ludlule.
• xelela ugqirha wakho ukuba ukhulelwe okanye ukuba ucwangcisa ukukhulelwa. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho ngemveliso yenaliti ye-rituximab kunye neenyanga ezili-12 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neentlobo zolawulo lokuzalwa oluza kukusebenzela. Ukuba ukhulelwa ngelixa usebenzisa imveliso yenaliti ye-rituximab, tsalela ugqirha wakho. I-Rituximab inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ngexesha lonyango lwakho ngemveliso yenaliti ye-rituximab kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela.
• Buza ugqirha wakho ukuba kufanelekile na ukufumana ugonyo ngaphambi kokuba uqale unyango lwakho ngemveliso yenaliti ye-rituximab. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphoswa idinga lokufumana imveliso yenaliti ye-rituximab, tsalela ugqirha kwangoko.

Iimveliso zenaliti ye-Rituximab zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• umqolo okanye iintlungu ezidibeneyo
• ukugungxula
• ukubila ebusuku
• ukuziva uxhalabile ngokungaqhelekanga okanye ukhathazekile

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukugruzuka okanye ukopha okungaqhelekanga
• umqala obuhlungu, impumlo ebusayo, ukukhwehlela, umkhuhlane, ukugodola, okanye ezinye iimpawu zosulelo
• indlebe
• ukuchama kabuhlungu
• ubomvu, ukuthamba, ukudumba okanye ukufudumala kwendawo yesikhumba
• ukuqina kwesifuba

Iimveliso zenaliti yeRituximab zinokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Rituxan^® (rituximab)
• Ukuxhamla^® (rituximab-pvvr)
• Truxima^® (rituximab-abbs)