Vorinostat

Umxholo

• Ngaphambi kokuba uthathe i-vorinostat,
• IVorinostat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

I-Vorinostat isetyenziselwa ukunyanga i-T-cell lymphoma (CTCL, uhlobo lomhlaza) kubantu abanesifo esingakhange siphuculwe, siye sanda ngakumbi, okanye sabuya emva kokuthatha amanye amayeza. IVorinostat ikwiklasi yamayeza abizwa ngokuba yi-histone deacetylase (HDAC) inhibitors. Isebenza ngokubulala okanye ukuyeka ukukhula kweeseli zomhlaza.

IVorinostat iza njengephilisi emayithathwe ngomlomo. Ihlala ithathwa kanye ngemini ngokutya. Ugqirha wakho uza kukuxelela ukuba uthathe i-vorinostat yonke imihla okanye kuphela ngeentsuku ezithile zeveki. Thatha i-vorinostat malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-vorinostat ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; sukuwavula, uwahlafune, okanye uwaqhekeze. Ukuba awukwazi ukuginya yonke iicapsule, tsalela ugqirha wakho. Ukuba ii-vorinostat capsules zivulwe ngengozi okanye zityunyuziwe, ungazichukumisi njengezingxobo okanye umgubo. Ukuba umgubo ovela kwisicubu esivulekileyo okanye esityumkileyo sifika kulusu lwakho okanye emehlweni okanye empumlweni, hlamba loo ndawo kakuhle ngamanzi amaninzi kwaye ubize ugqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-vorinostat,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-vorinostat, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-vorinostat capsules. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-anticoagulants ('blood thinner') ezifana ne-warfarin (Coumadin, Jantoven), belinostat (Beleodaq), kunye ne-valproic acid (Depakene). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba unesicaphucaphu, ukugabha, okanye urhudo; kwaye ukuba ukhe wabanegazi emiphungeni okanye umthambo (umthambo wegazi); iswekile yegazi ephezulu okanye isifo seswekile; arrhythmias (ukubetha kwentliziyo okungaqhelekanga okanye iingxaki zesingqisho sentliziyo); amanqanaba asezantsi e-potassium okanye i-magnesium, kunye nentliziyo, izintso, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka uthathe uvavanyo lokukhulelwa ubuncinci kwiintsuku ezisi-7 ngaphambi kokuqala unyango. Ukuba ungumfazi okwaziyo ukukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-6 emva kwedosi yakho yokugqibela. Ukuba uyindoda kunye neqabane lomfazi onokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela. Ukuba ukhulelwa ngelixa uthatha i-vorinostat, biza ugqirha ngokukhawuleza. IVorinostat inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncancise ngelixa uthatha i-vorinostat kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba i-vorinostat inokukwenza wozele. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• Kuya kufuneka uyazi ukuba i-vorinostat inokubangela ukonyuka kweglucose egazini. Ukuba unesifo seswekile okanye iswekile ephezulu yegazi, jonga iswekile yakho yegazi rhoqo njengoko kuyalelwa ngugqirha. Ukuba iswekile yegazi lakho iphezulu kunesiqhelo, tsalela umnxeba kugqirha wakho. Xelela ugqirha wakho kwangoko ukuba unayo nayiphi na kwezi mpawu zilandelayo ngelixa uthatha i-vorinostat: ukunxanwa okugqithisileyo, ukuchama rhoqo, ukulamba kakhulu, ukungaboni kakuhle, okanye ubuthathaka. Kubaluleke kakhulu ukubiza ugqirha wakho nje ukuba ube nazo naziphi na ezi mpawu, kuba iswekile ephezulu yegazi enganyangekiyo inokubangela imeko embi ebizwa ngokuba yi ketoacidosis. I-Ketoacidosis inokuba sengozini yobomi ukuba ayinyangwa kwangoko. Iimpawu zeketoacidosis zibandakanya umlomo owomileyo, isisu esibuhlungu kunye nokugabha, ukuphefumla kancinci, ukuphefumla okunuka iziqhamo kunye nokuncipha kwengqondo. Fowunela ugqirha wakho ukuba awukwazi ukutya okanye ukusela ngesiqhelo ngenxa yesicaphucaphu, ukugabha, okanye urhudo ngelixa uthatha i-vorinostat.

Qiniseka ukuba usele ubuncinci i-8-ounce (240-milliliter) yeekomityi zamanzi okanye ezinye izinto ezilulwelo yonke imihla ngelixa uthatha i-vorinostat ukuze ungabi namanzi emzimbeni.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IVorinostat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• isicaphucaphu
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukugabha
• ukuqhina
• ukudinwa kakhulu
• Ukugodola
• utshintsho kwindlela izinto ezingcamla ngayo
• umlomo owomileyo
• ukulahleka kweenwele
• isiyezi
• ukudumba kwemilenze, iinyawo, okanye amaqatha
• ukurhawuzelela
• ukukhohlela
• ifiva
• intloko ebuhlungu
• iintlungu zemisipha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukopha okungaqhelekanga okanye ukugruzuka
• ulusu oluthuthu
• ukudumba ngesiquphe, ukuba bomvu, ukufudumala, iintlungu, kunye / okanye ukuthamba emlenzeni
• ububomvu bolusu okanye utshintsho kumbala wolusu
• iintlungu ezibukhali esifubeni
• ukuqhawukelwa ngumphefumlo
• ukhohlela igazi
• ukubila
• ukubetha kwentliziyo ngokukhawuleza
• isiqaqa
• ndiziva ndixhalabile

IVorinostat inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-vorinostat.

Ngaphambi kokuba uvavanywe elebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-vorinostat.

Musa ukuvumela nabani na ukuba athathe amayeza akho, buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UZolinza^®