I-Sunitinib

Umxholo

• Ngaphambi kokuba uthathe i-sunitinib,
• I-Sunitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo esiXwayiso ESIBALULEKILEYO okanye AMANYATHELO AQHELEKILEYO, tsalela umnxeba kwangoko:

I-Sunitinib inokubangela umonakalo omkhulu okanye osongela ubomi kwisibindi. Tshela ugqirha wakho ukuba ukhe unesifo sesibindi okanye uneengxaki kwisibindi sakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukurhawuzelela, amehlo atyheli kunye nolusu, umchamo omnyama, okanye iintlungu okanye ukungonwabi kwindawo elungileyo yesisu. Ugqirha wakho unokunciphisa idosi yakho ye-sunitinib okanye ngokusisigxina okanye okwexeshana uyeke unyango lwakho.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zegazi ngaphambi kwaye ngexesha lonyango lwakho ukuze uqiniseke ukuba kukhuselekile kuwe ukuba uthathe i-sunitinib kwaye ujonge impendulo yomzimba wakho kunyango.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-sunitinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga neengozi zokuthatha i-sunitinib.

I-Sunitinib isetyenziselwa ukunyanga izicubu zesisu esiswini (GIST; uhlobo lwesisu esikhula esiswini, emathunjini (emathunjini), okanye kwisophagus (ityhubhu edibanisa umqala nesisu) kubantu abanezilonda ezingakhange ziphathwe ngempumelelo nge-imatinib ( I-Sunitinib ikwasetyenziselwa ukunyanga i-renal cell carcinoma (RCC, uhlobo lomhlaza oluqala kwiiseli zezintso) .I-Sunitinib ikwasetyenziselwa ukunceda ukuthintela ukubuya kwe-RCC kubantu une-RCC engasasazekanga kwaye ikhutshwe izintso.Sunitinib ikwasetyenziselwa ukunyanga amathumba epancreatic neuroendocrine (pNET, uhlobo lwethumba eliqala kwiiseli ezithile zepancreas) kubantu abanezilonda eziye zanda kwaye azinakunyangwa I-Sunitinib ikudidi lwamayeza ekuthiwa yi-kinase inhibitors.Isebenza ngokuthintela ukusebenza kweprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande.Oku kunceda ukunqanda okanye ukucothisa ukusasazeka kweeseli zomhlaza kwaye kunokunceda shwabanisa amathumba.

I-Sunitinib iza njengepilisi yokuthatha ngomlomo kunye nangaphandle kokutya. Unyango lwesisu esiswini (GIST), okanye unyango lwe-renal cell carcinoma (RCC), i-sunitinib ihlala ithathwa kanye ngemini kangangeeveki ezi-4 (iintsuku ezingama-28) kulandelwa ikhefu leeveki ezi-2 ngaphambi kokuqala komjikelo olandelayo wedosi kwaye iphindwe rhoqo kwiiveki ezi-6 okoko ugqirha ekucebisa. Ukuthintela i-RCC, i-sunitinib ihlala ithathwa kanye ngemini kangangeeveki ezi-4 (iintsuku ezingama-28) kulandelwa ikhefu leeveki ezi-2 ngaphambi kokuqala komjikelo olandelayo wedosi kunye nokuphindaphinda iiveki ezi-6 zemijikelo eli-9. Unyango lwe-pancreatic neuroendocrine tumors (pNET), i-sunitinib ihlala ithathwa kanye yonke imihla. Thatha i-sunitinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-sunitinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya zonke iifomsile; ungahluleli, ungahlaleli, okanye uzityumze. Musa ukuvula iifomsile.

Kuya kufuneka uthathe iicapsule enye okanye ezingaphezulu ngexesha kuxhomekeke kwidosi yakho ye-sunitinib.

Ugqirha wakho unokunyusa kancinci okanye anciphise idosi yakho ye-sunitinib ngexesha lonyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe i-sunitinib nokuba uziva uphilile. Ungayeki ukuthatha i-sunitinib ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-sunitinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-sunitinib, naziphi na izithako zeepilisi ze-sunitinib, okanye nayiphina imithi. Buza usokhemesti wakho okanye ujonge iphepha lolwazi lomguli lomenzi (Isikhokelo seyeza) uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: ii-antibiotics ezithile ezifana ne-clarithromycin (i-Biaxin, kwi-Prevpac), i-rifampin (i-Rifadin, i-Rimactane, i-Rifamate, i-Rifater), i-rifabutin (i-Mycobutin), i-rifapentine (i-Priftin), kunye ne-telithromycin (i-Ketek); ii-antifungals ezithile ezinje nge-itraconazole (Onmel, Sporanox), ketoconazole, kunye ne-voriconazole (Vfend); dexamethasone; amayeza seswekile; amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye i-immunodeficiency syndrome (i-AIDS) kubandakanya i-atazanavir (Reyataz, e-Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra), kunye ne-saquinavir (Invirase); nefazodone; amayeza athile okubanjwa afana ne-carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, kunye ne phenytoin (Dilantin, Phenytek). Xelela ugqirha wakho ukuba uthatha okanye uthathe i-alendronate (Binosto, Fosamax), etidronate, ibandronate (Boniva), pamidronate, risedronate (Actonel, Atelvia), okanye inaliti ye-zoledronic acid (Reclast, Zometa), Amanye amayeza anokusebenzisana sunitinib, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho kunye nosokhemisti ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi i-wort yaseSt. Musa ukuthatha i-wort yaseSt. John ngelixa uthatha i-sunitinib.
• xelela ugqirha wakho ukuba ukhe wanengxaki yokopha; ihlwili legazi emiphungeni; Ukongezwa kwekhefu le-QT (isingqisho sentliziyo esingaqhelekanga esinokukhokelela ekuphelelweni lithemba, ukulahleka kwengqondo, ukuxhuzula, okanye ukufa ngesiquphe); ukubetha kwentliziyo okukhawulezayo, okukhawulezayo, okanye okungaqhelekanga; isifo sentliziyo; ukumelwa yintliziyo; igazi elonyukayo; ukuxhuzula; iswekile esezantsi yegazi okanye isifo seswekile; amanqanaba asezantsi e-potassium okanye i-magnesium egazini lakho; iingxaki ngomlomo, ngamazinyo okanye ngeentsini; okanye izintso, idlala lengqula, okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba notata umntwana. Wena okanye iqabane lakho akufuneki ukuba ukhulelwe ngelixa uthatha i-sunitinib. Ukuba ungumfazi, kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango, kwaye kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho lwe-sunitinib kunye neeveki ezi-4 emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena kunye neqabane lakho kufuneka nisebenzise ukuzalwa ukuthintela ukukhulelwa ngexesha lonyango kunye ne-sunitinib kunye neeveki ezisi-7 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. I-Sunitinib inokunciphisa ukuzala kwamadoda nabasetyhini. Nangona kunjalo, awufanelanga ukucinga ukuba wena okanye iqabane lakho aninakukhulelwa. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-sunitinib, biza ugqirha wakho. I-Sunitinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngexesha lonyango lwakho nge-sunitinib kunye neeveki ezi-4 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-sunitinib. Ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-sunitinib ubuncinci iiveki ezi-3 ngaphambi kotyando lwakho olucwangcisiweyo kuba lunokuchaphazela ukuphilisa amanxeba. Ugqirha wakho uya kukuxelela ukuba uqale nini ukuthatha i-sunitinib kwakhona emva kotyando lwakho.
• Kuya kufuneka uyazi ukuba i-sunitinib inokubangela ukuba ulusu lwakho lujike lube tyheli kwaye neenwele zakho zikhanyise kwaye zilahle umbala. Oku kusenokwenzeka ukuba kubangelwa ngumbala otyheli wamayeza kwaye akuyongozi okanye kubuhlungu.
• Kuya kufuneka uyazi ukuba i-sunitinib inokubangela uxinzelelo lwegazi oluphezulu. Uxinzelelo lwegazi kufuneka luhlolwe rhoqo ngelixa uthatha i-sunitinib.
• Kuya kufuneka uyazi ukuba i-sunitinib inokubangela i-osteonecrosis yomhlathi (ONJ, imeko enzima yethambo lomhlathi), ngakumbi ukuba utyando lwamazinyo okanye unyango ngelixa uthatha amayeza. Ugqirha wamazinyo kufuneka ahlolisise amazinyo akho kwaye enze naluphi na unyango olufunekayo, kubandakanya ukucoca okanye ukulungisa amazinyo okufakela angalunganga, ngaphambi kokuba uqale ukuthatha i-sunitinib. Qiniseka ukuba uhlamba amazinyo kwaye ucoce umlomo wakho ngokufanelekileyo ngelixa uthatha i-sunitinib. Xelela ugqirha wakho okanye ugqirha wamazinyo ukuba ukhe wakha wanomlomo, amazinyo, okanye iintlungu zomhlathi; izilonda zomlomo okanye ukudumba; ukuba ndindisholo okanye uvakalelo lobunzima emhlathini; okanye nawaphi na amazinyo. Thetha nogqirha wakho ngaphambi kokuba ufumane unyango lwamazinyo ngelixa uthatha eli yeza.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Ukuba uphosa idosi ye-sunitinib ngaphantsi kweeyure ezili-12, thatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule kwaye emva koko uthathe idosi elandelayo ngexesha elimiselweyo. Nangona kunjalo, ukuba uphosa idosi ngaphezulu kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Sunitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubuthathaka
• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• isilungulela
• irhasi
• Iimpawu
• intlungu, ukucaphuka, okanye ukutsha kwemilebe, ulwimi, umlomo okanye umqala
• umlomo owomileyo
• utshintsho kwindlela izinto ezingcamla ngayo
• Ukuphelelwa ngumdla wokutya
• utshintsho lobunzima
• ukulahleka kweenwele
• inzipho, ubhontsi wamakhaphu okanye iinwele
• intetho ecothayo
• isikhumba esiluthuthu okanye esomileyo
• ndingcangcazela
• ixesha elinzima, elingaqhelekanga, okanye elilahlekileyo lokuya esikhathini
• ukudakumba
• ubunzima bokulala okanye ukulala
• ukoma, ukutyeba, ukuqhekeka, okanye ukudumba kolusu ezintendeni zezandla kunye naphantsi kweenyawo
• intlungu yesihlunu, edibeneyo, yomqolo, okanye yelungu
• iimpumlo zeempumlo rhoqo
• ukopha kwiintsini zakho
• ukungonwabisi okungaqhelekanga kumaqondo obushushu abandayo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kumacandelo esiXwayiso ESIBALULEKILEYO okanye AMANYATHELO AQHELEKILEYO, tsalela umnxeba kwangoko:

• ukugruzuka okanye ukopha okungaqhelekanga
• enegazi okanye emnyama kunye nezitulo ezilindileyo
• igazi kumchamo
• ukugabha okubomvu ngokuqaqambileyo okanye okujongeka njengendawo yekofu
• ukhohlela igazi
• isisu esibuhlungu, ukudumba, okanye ukuthamba
• intloko ebuhlungu
• ifiva
• ukudumba, ukuthamba, ukufudumala, okanye ubomvu bomlenze
• ukudumba kweenyawo okanye amaqatha
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• isiyezi okanye isiqaqa
• ukuncipha kokujonga okanye ukugxila
• ukudideka
• ukudakumba
• uvalo
• ukuxhuzula
• utshintsho lombono
• iintlungu esifubeni okanye uxinzelelo
• ukudinwa kakhulu
• ukuqhawukelwa ngumphefumlo
• iintlungu ngokuphefumla okunzulu
• ukuzuza ubunzima obungachazwanga
• ukuncipha kokuchama
• umchamo onamafu
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, okanye umqala
• irhashalala
• urhwebo
• ukudumba okanye ukuxobuka kolusu okanye umlomo
• ubunzima bokuginya okanye ukuphefumla
• ukudinwa

I-Sunitinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ezithile ezinje ngee-electrocardiograms (EKG, uvavanyo olurekhoda umsebenzi wombane wentliziyo), ii-echocardiograms (uvavanyo olusebenzisa amaza esandi ukulinganisa ukubanakho kwempompo yegazi), kunye novavanyo lomchamo ngaphambi nangexesha lokunyanga kwakho ukuqinisekisa ukuba kukhuselekile ukuba ungathatha i-sunitinib, kwaye ujonge impendulo yomzimba wakho kunyango.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Ngobuqhetseba^®