I-Lapatinib

Umxholo

• Ngaphambi kokuba uthathe i-lapatinib,
• ILapatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO okanye icandelo LOKULUMKELA OKHETHEKILEYO, tsalela ugqirha wakho ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Lapatinib inokubangela ukonakala kwesibindi okunokuba nzima okanye ukusongela ubomi. Umonakalo wesibindi unokwenzeka kwakamsinya kwiintsuku ezininzi okanye emva kweenyanga ezininzi emva kokuqala konyango nge-lapatinib. Xelela ugqirha wakho ukuba ukhe unesifo sesibindi. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukurhawuzelela, ukutyheli kolusu okanye amehlo, umchamo omnyama, iintlungu kwinxalenye ephezulu yesisu, ukopha okungaqhelekanga okanye ukugruzuka, okanye ilindle okanye isitulo esimnyama.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zaselebhu ngaphambi kwaye ngexesha lonyango lwakho ukuze abone ukuba ingaba isibindi sakho sinokonakaliswa okanye sonakaliswe yi-lapatinib.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-lapatinib.

I-Lapatinib isetyenziswa kunye ne-capecitabine (i-Xeloda) ukunyanga uhlobo oluthile lomhlaza webele osele uhambile kubantu abasele bephethwe ngamanye amayeza e-chemotherapy. I-Lapatinib ikwasetyenziswa kunye ne-letrozole (Femara) ukunyanga uhlobo oluthile lomhlaza webele kubantu basetyhini abasemva kwemini (abasetyhini abaye bafumana utshintsho kubomi, ukuphela kwexesha lokuya exesheni) okunwenwele kwamanye amalungu omzimba. ILapatinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

ILapatinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini, ubuncinci iyure enye ngaphambi okanye iyure enye emva kwesidlo. Xa i-lapatinib isetyenziselwa ukunyanga umhlaza webele osele uhambile okanye we-metastatic, ihlala inikwa kanye yonke imihla ngeentsuku zoku-1 ukuya kwezingama-21 (kunye ne-capecitabine ngeentsuku ezi-1 ukuya kwezi-14) zomjikelo weentsuku ezingama-21. Umjikelo unokuphindwa njengoko ucetyiswa ngugqirha wakho. Xa i-lapatinib isetyenziselwa ukunyanga umhlaza webele kubafazi abasemva kokuya exesheni, ihlala inikwa kanye yonke imihla kunye neletrozole. Thatha onke amacwecwe e-lapatinib yedosi yakho yemihla ngemihla ngexesha elinye ngosuku; musa ukwahlula iipilisi ukuba zithathe njengeedosi ezahlukileyo. Thatha i-lapatinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-lapatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokunyusa kancinci okanye anciphise idosi ye-lapatinib ngexesha lonyango lwakho. Oku kuxhomekeke ekubeni lisebenza njani na iyeza kunye naziphi na iziphumo ebezingalindelekanga onokuzifumana. Qhubeka nokuthatha i-lapatinib nokuba uziva uphilile. Sukuyeka ukuthatha i-lapatinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-lapatinib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-lapatinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-lapatinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: ii-antibiotics ezithile ezifana ne-clarithromycin (i-Biaxin, kwi-Prevpac), i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin), i-moxifloxacin (i-Avelox), i-rifabutin (i-Mycobutin), i-rifampin (i-Rifadin, e-Rifamate, in Rifater, Rimactane), rifapentine (Priftin), sparfloxacin (Zagam) (ayifumaneki e-US), kunye ne-telithromycin (Ketek); ii-antifungals ezifana ne-itraconazole (Sporanox), ketoconazole (Nizoral), kunye ne-voriconazole (Vfend); iicalcium block blockers ezinje ngeamlodipine (Norvasc, eCaduet naseLotrel), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil, e Lexxel), nifedipine (Adalat, Nifedical XL, Procardia, abanye), nisoldipine (Sular) , kunye neverapamil (Calan, Isoptin, Verelan, nabanye); i-cisapride (Propulsid) (ayifumaneki e-U.S.); dexamethasone (iDecadron, iDexpak); amayeza athile okudakumba afana ne-nefazodone; amayeza athile e-chemotherapy kubandakanya i-daunorubicin (Cerubidine, DaunoXome), doxorubicin (Adriamycin, Doxil, Rubex), epirubicin (Ellence), idarubicin (Idamycin), tamoxifen (Nolvadex), valrubicin (Valstar), vinblastine, amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye i-immunodeficiency syndrome (i-AIDS) kubandakanya i-atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra), kunye ne-saquinavir (i-Invirase); amayeza okubetha kwentliziyo ngokungaqhelekanga kubandakanya i-amiodarone (Cordarone), i-disopyramide (i-Norpace), i-dofetilide (Tikosyn), i-procainamide (i-Procanbid), i-quinidine, kunye ne-sotalol (i-Betapace, i-Betapace AF, i-Sorine); amayeza athile okubanjwa afana ne-carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital (Luminal), kunye ne phenytoin (Dilantin, Phenytek); ipimozide (Orap); kunye ne-thioridazine. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-lapatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho kunye nosokhemisti ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi i-wort yaseSt.
• xelela ugqirha wakho ukuba ukhe wakha wacotha, wakhawuleza, okanye akabetha entliziyweni; ixesha elide leQT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe); inqanaba eliphantsi le-magnesium okanye i-potassium egazini lakho; okanye isifo sentliziyo okanye semiphunga.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango. Ukuba ungumfazi okwaziyo ukukhulelwa, kuya kufuneka usebenzise ulawulo olusebenzayo lokuzalwa ngexesha lonyango kunye nakwiveki e-1 emva kwethamo lakho lokugqibela. Ukuba uyindoda kunye neqabane lomfazi onokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho kunye neveki e-1 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-lapatinib, biza ugqirha wakho ngokukhawuleza. ILapatinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-lapatinib kunye neveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba i-lapatinib ihlala ibangela urhudo, olunokuba lukhulu. Biza ugqirha wakho ukuba urhudo ngelixa uthatha i-lapatinib. Ugqirha wakho angakuxelela ukuba usele into engamanzi, wenze utshintsho kwindlela otya ngayo, kwaye uthathe amayeza ukulawula urhudo kunye nokuthintela ukomisa (ukulahleka kwamanzi amaninzi emzimbeni wakho). Tsalela umnxeba kwangoko ukuba unazo naziphi na kwezi mpawu zilandelayo zokoma: ukoma kakhulu, umlomo owomileyo kunye / okanye ulusu, ukuncipha komchamo, amehlo atshonileyo, okanye ukubetha kwentliziyo okukhawulezayo.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule ngalo mini. Nangona kunjalo, ukuba awukhumbuli kude kube lusuku olulandelayo, ukuba awukhumbuli ukuba uwathathile na amayeza, okanye ukuba uyagabha amayeza akho, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ILapatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• isilungulela
• izilonda emilebeni, emlonyeni, nasemqaleni
• Ukuphelelwa ngumdla wokutya
• bomvu, buhlungu, ndindisholo, okanye ukurhawuzelela izandla neenyawo
• isikhumba esomileyo
• iintlungu ezingalweni, emilenzeni, okanye emqolo
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO okanye icandelo LOKULUMKELA OKHETHEKILEYO, tsalela ugqirha wakho ngokukhawuleza:

• ukuqhawukelwa ngumphefumlo
• ukukhohlela owomileyo
• ukukhohlela upinki okanye i-mucus enegazi
• ngokukhawuleza, ngokungaqhelekanga, okanye ukubetha kwentliziyo
• ubuthathaka
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• irhashalala
• ifiva
• ukudumba okanye ukuxobuka kolusu

I-Lapatinib inokutshintsha indlela intliziyo yakho ebetha ngayo kunye neempompo zegazi emzimbeni wakho. Ugqirha wakho uya kukujonga ngononophelo ukuze abone ukuba i-lapatinib ichaphazele intliziyo yakho. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-lapatinib.

ILapatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• urhudo
• ukugabha

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• ITykerb^®