IPazopanib

Umxholo

• Ngaphambi kokuthatha ipazopanib,
• I-Pazopanib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Pazopanib inokubangela ukonakala kwesibindi okanye ukusongela ubomi Xelela ugqirha wakho ukuba ukhe unesifo sesibindi. Ukuba uhlangabezana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko kugqirha: tyheli kolusu okanye kwamehlo; umchamo omnyama; ukudinwa kakhulu; isicaphucaphu; ukugabha; ukuphelelwa ngumdla wokutya; iintlungu kwindawo ephezulu yesisu; ukopha okungaqhelekanga okanye ukugruzuka.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngaphambi kokuba uqale ukuthatha ipazopanib kwaye ubuncinci kanye ngenyanga kwinyanga zokuqala ezi-4 zonyango lwakho kwaye rhoqo njengoko kufuneka.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwezigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-pazopanib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko wokuthatha ipazopanib.

I-Pazopanib isetyenziselwa ukunyanga i-renal cell carcinoma (RCC, uhlobo lomhlaza oqala kwiiseli zezintso) kubantu abadala. I-Pazopanib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokunciphisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Pazopanib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa ngaphandle kwesisu kanye ngemini, ubuncinci iyure enye ngaphambi okanye iiyure ezi-2 emva kwesidlo. Thatha ipazopanib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha ipazopanib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho unokuhlengahlengisa idosi yakho yepazopanib ngexesha lonyango lwakho okanye unokuyekisa unyango lwakho. Oku kuxhomekeke ekubeni lisebenza njani na iyeza kunye naziphi na iziphumo ebezingalindelekanga onokuzifumana. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe i-pazopanib nokuba uziva uphilile. Sukuyeka ukuthatha ipazopanib ungakhange uthethe nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha ipazopanib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-pazopanib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-pazopanib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: cisapride (Propulsid) (ayifumaneki eMelika); i-clarithromycin (i-Biaxin, kwi-Prevpac); dofetilide (iTikosyn); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); ketoconazole (Nizoral); amayeza athile okubetha kwentliziyo ngokungaqhelekanga njenge-amiodarone (Cordarone), digoxin (Digitek, Lanoxicaps, Lanoxin), diltiazem (Cardizem, Dilacor, Tiazac, others), disopyramide (Norpace), flecainide (Tambocor), mexiletine (Mexitil), procainamide ), propafenone (Rythmol), propranolol (Inderal, Innopran XL, eInderide), quinidine, sotalol (Betapace, Betapace AF, Sorine), kunye verapamil (Calan, Isoptin, Verelan); moxifloxacin (Avelox); ipimozide (Orap); irifampin (Rifadin, eRifamate, eRifater, eRimactane); i-ritonavir (iNorvir, eKaletra); i-sparfloxacin (iZagam) (ayifumaneki e-US); kunye ne-thioridazine (Mellaril). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana nepazopanib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhohlele igazi okanye ukopha esiswini, emathunjini, okanye kwingqondo kwiinyanga ezi-6 ezidlulileyo okanye utyando kwiintsuku ezisi-7 ezidlulileyo. Xelela ugqirha wakho ukuba ukhe wakha wakhalamba esiswini okanye emathunjini; unxibelelwano olungaqhelekanga phakathi kwamacandelo amabini ephecana lesisu sakho; Isifo sikaGilbert (imeko yemfuza echaphazela isibindi kwaye inokubangela i-jaundice [tyheli kolusu okanye amehlo]); igazi elonyukayo; ukubetha; ukubetha kwentliziyo ngokungaqhelekanga; ixesha elide leQT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe); isifo sentliziyo; iintlungu zesifuba; okanye isifo sentliziyo okanye se-thyroid.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Akufanele ukhulelwe ngelixa uthatha ipazopanib. Ukuba ukhulelwa ngelixa uthatha i-pazopanib, tsalela ugqirha wakho. I-Pazopanib inokulimaza umbungu.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha ipazopanib.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphakathi kweeyure ezili-12 zedosi yakho ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Pazopanib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• ukuqhina
• isilungulela
• utshintsho kwisakhono sokungcamla ukutya
• intlungu edibeneyo okanye yemisipha
• ukudumba kobuso
• ithenda, izintende ezibomvu zezandla kunye neentende zeenyawo
• ukulahleka kweenwele
• inzipho, ubhontsi wamakhaphu okanye iinwele
• utshintsho kumbala weenwele
• ukukhanya kwendawo yesikhumba
• irhashalala
• ubuthathaka
• ukudakumba
• ukungonwabisi okungaqhelekanga kumaqondo obushushu abandayo
• ukuhla ukusinda

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• iintlungu zesifuba
• iintlungu ezingalweni, emqolo, entanyeni okanye emhlathini
• ukuqhawukelwa ngumphefumlo
• intloko ebuhlungu
• intetho ecothayo okanye enzima
• isiyezi okanye ukudinwa
• ubuthathaka okanye ukuba ndindisholo kwengalo okanye umlenze
• amanxeba angapholiyo
• isisu esibuhlungu okanye ukudumba
• izitulo ezimnyama kunye nokulinda
• Igazi elibomvu ilindle
• ukugabha okunegazi
• ukugabha okujongeka njengendawo yekofu
• igazi kumchamo
• impumlo
• ukhohlela igazi

I-Pazopanib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• ukudinwa kakhulu

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Votrient^®