Inaliti yeTocilizumab

Umxholo

• Inaliti yeTocilizumab isetyenziswa yodwa okanye idityaniswe namanye amayeza ukunciphisa iimpawu zeentlobo ezithile zesifo samathambo kunye nezinye iimeko kubandakanya:
• Ngaphambi kokufumana inaliti ye-tocilizumab,
• Inaliti yeTocilizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Ukusebenzisa inaliti ye-tocilizumab kunokunciphisa ukubanakho kwakho ukulwa nosulelo kwiibhaktiriya, intsholongwane, kunye nefungi kwaye wandise umngcipheko wokuba ufumane usulelo olubi okanye olusongela ubomi olunokuthi lusasazeke emzimbeni. Tshela ugqirha wakho ukuba uhlala ufumana naluphi na uhlobo losulelo okanye ukuba unayo okanye ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Oku kubandakanya usulelo oluncinci (njengokusikwa okuvulekileyo okanye izilonda), usulelo olufikayo (olufana nezilonda ezibandayo), kunye nosulelo oluqhubekayo olungapheliyo. Xelela ugqirha wakho ukuba ukhe unesifo seswekile, intsholongwane kaGawulayo, okanye nayiphi na imeko echaphazela amajoni akho omzimba, kwaye ukuba uyaphila, ukhe waphila, okanye waya kwiindawo ezinjengeentlambo zoMlambo iOhio neMississippi kunye noMzantsi-ntshona apho izifo ezinzulu zokungunda zixhaphake kakhulu. Buza ugqirha wakho ukuba awazi ukuba ngaba ezi zifo zixhaphakile kwindawo yakho. Xelela ugqirha wakho ukuba uthatha: i-abatacept (i-Orencia); adalimumab (Humira); anakinra (iKineret); isatifikethi (Cimzia); etanercept (Enbrel); igolimumab (iSimponi); infliximab (Remicade); amayeza athintela amajoni omzimba afana ne-azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Otrexup, Trexall, abanye), sirolimus (Rapamune), kunye netacrolimus (Prograf); i-steroids yomlomo efana ne-dexamethasone, i-methylprednisolone, kunye ne-prednisone (iRayos); okanye i-rituximab (Rituxan). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngoko nangoko: umkhuhlane; Ukugodola; ukubila; ubunzima bokuphefumla; umqala obuhkungu; ukukhohlela; ukuhla ukusinda; urhudo; isisu esibuhlungu; igazi kwi-phlegm; ukudinwa kakhulu; iintlungu zemisipha; ulusu olufudumeleyo, olubomvu, okanye olubuhlungu; izilonda eluswini okanye emlonyeni; ukutshisa xa uchama; ukuchama rhoqo; okanye ezinye iimpawu zosulelo.

Unokosulelwa sisifo sephepha (i-TB; uhlobo losulelo lwemiphunga) okanye i-hepatitis B (uhlobo lwesifo sesibindi) kodwa ungabinazo iimpawu zesi sifo. Kule meko, inaliti ye-tocilizumab inokunyusa umngcipheko wokuba usulelo lwakho lube lubi kakhulu kwaye uya kuba neempawu. Ugqirha wakho uza kwenza uvavanyo lolusu ukuze abone ukuba unesifo se-TB esingasebenziyo kwaye angayalela ukuba kwenziwe uvavanyo lwegazi ukuze abone ukuba unesifo se-hepatitis B esingasebenziyo. Ukuba kukho imfuneko, ugqirha wakho uya kukunika amayeza ukunyanga olu sulelo ngaphambi kokuba uqale ukusebenzisa inaliti ye-tocilizumab. Xelela ugqirha wakho ukuba ukhe wakha wahlaselwa yi-TB okanye yi-hepatitis B, ukuba ukhe watyelela naliphi na ilizwe apho ixhaphakileyo i-TB, okanye ukuba ukhe wakunye nomntu one-TB. Ukuba unazo naziphi na kwezi mpawu zilandelayo ze-TB, okanye ukuba uvela kwezi mpawu ngexesha lonyango lwakho, tsalela umnxeba kwangoko: ukukhohlela, iintlungu esifubeni, ukukhohlela igazi okanye amafinyila, ubuthathaka okanye ukudinwa, ukwehla emzimbeni, ukungabi namdla wokutya, Ukugodola, umkhuhlane, okanye ukubila ebusuku. Biza ugqirha ngoko nangoko ukuba unayo nayiphi na le mpawu yesifo sokudumba kwesibindi kohlobo B okanye ukuba ukhula kwezi mpawu ngexesha okanye emva konyango lwakho: ukudinwa kakhulu, ukuba tyheli kolusu okanye amehlo, ukungabi namdla, isicaphucaphu, ukugabha, iintlungu zemisipha, umchamo omnyama, intshukumo yombala wodongwe, umkhuhlane, ukugodola, iintlungu zesisu, okanye irhashalala.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyibeka esweni impilo yakho ukuze uqiniseke ukuba awuzukuhlakulela usulelo olubi. Ugqirha wakho uya ku-odola iimvavanyo ezithile zelebhu ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-tocilizumab injection.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti ye-tocilizumab kwaye ngalo lonke ixesha ufumana iyeza. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga neengozi zokusebenzisa inaliti ye-tocilizumab.

Inaliti yeTocilizumab isetyenziswa yodwa okanye idityaniswe namanye amayeza ukunciphisa iimpawu zeentlobo ezithile zesifo samathambo kunye nezinye iimeko kubandakanya:

• i-rheumatoid arthritis (imeko apho umzimba uhlasela amalungu ayo, ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) kubantu abangakhange bancedwe zezinye iziyobisi ezitshintsha isifo (i-DMARDs),
• i-cell cell arteritis (imeko ebangela ukudumba kwemithambo yegazi, ngakumbi entlonzeni nasentloko),
• polyarticular juvenile idiopathic arthritis (PJIA; uhlobo lwesifo samathambo ebuntwaneni esichaphazela amalunga amahlanu okanye nangaphezulu kwiinyanga ezintandathu zokuqala kwimeko, kubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) kubantwana abaneminyaka emi-2 ubudala okanye ngaphezulu.
• Inkqubo yolutsha lwe-idiopathic arthritis (SJIA; imeko ebantwaneni ebangela ukudumba kwiindawo ezahlukeneyo zomzimba, kubangela umkhuhlane, iintlungu ezidibeneyo kunye nokudumba, ukuphulukana nomsebenzi, kunye nokulibaziseka kokukhula kunye nophuhliso) kubantwana abaneminyaka emi-2 ubudala okanye ngaphezulu,
• i-cytokine release syndrome (impendulo enobuzaza kwaye esongela ubomi) eyenzeka kubantu abadala nakubantwana abaneminyaka emi-2 ubudala okanye ngaphezulu emva kokufumana ukumiliselwa okuthile kwe-immunotherapy.

Inaliti yeTocilizumab ikudidi lwamayeza abizwa ngokuba yi-interleukin-6 (IL-6) receptor inhibitors. Isebenza ngokuthintela ukusebenza kwe-interleukin-6, into esemzimbeni ebangela ukudumba.

Inaliti yeTocilizumab iza njengesisombululo (ulwelo) sokujova ngaphakathi (emthanjeni) engalweni ngugqirha okanye umongikazi kwiofisi yezonyango okanye kwiklinikhi yezigulana ezingalaliswanga esibhedlele okanye njengesirinji ekhethiweyo yokujova (ngaphantsi kolusu) ngokwakho ekhaya. Xa i-tocilizumab inikwa ngaphakathi ngaphakathi ukunyanga i-rheumatoid arthritis okanye i-polyarticular juvenile idiopathic arthritis, ihlala inikwa kanye kwiiveki ezi-4. Xa i-tocilizumab inikwa ngaphakathi ngenaliti ukunyanga inkqubo yolutsha ye-idiopathic arthritis, ihlala inikwa kube kanye kwiiveki ezi-1 okanye ezi-2. Xa i-tocilizumab inikwa ngaphakathi ngaphakathi ukunyanga i-cytokine release syndrome, ihlala inikwa kube kanye, kodwa ukuya kuthi ga kwiidosi ezi-3 ezongezelelweyo zinokunikwa ubuncinci iiyure ezi-8. Kuya kuthatha malunga neyure e-1 ukuba ufumane idosi yakho ye-tocilizumab inaliti efakwa ngaphakathi. Xa i-tocilizumab inikwa ngendlela engeyiyo ukunyanga i-rheumatoid arthritis okanye i-giant cell arteritis, ihlala inikwa kanye ngeveki okanye kanye ngeveki nganye.

Uya kufumana idosi yakho yokuqala engaphantsi kwesitofu se-tocilizumab inaliti kwiofisi kagqirha wakho. Ukuba uza kutofa inaliti ye-tocilizumab ngokwakho ekhaya okanye unetshomi okanye isihlobo sikufakele iyeza, ugqirha wakho uya kukubonisa okanye umntu oza kungenza iyeza ukuba ungalitofa njani. Wena kunye nomntu oza kutofa iyeza kufuneka ufunde imiyalelo ebhaliweyo yokusetyenziswa okuza nonyango.

Imizuzu engamashumi amathathu ngaphambi kokuba ulungele ukujova inaliti ye-tocilizumab, kuya kufuneka ususe amayeza kwifriji, uyikhuphe ngaphandle kwebhokisi, kwaye uyivumele ukuba ifikelele kubushushu begumbi. Xa ususa isirinji ekhethiweyo ebhokisini, lumka ukuba ungachukumisi iminwe yesirinji. Sukuzama ukufudumeza amayeza ngokuwatshisa kwimicrowave, ngokuwabeka emanzini afudumeleyo, okanye ngayo nayiphi na enye indlela.

Musa ukuyisusa ikepusi kwisirinji ekhethiweyo ngelixa iyeza lifudumala. Kuya kufuneka uyisuse ikepusi kungadluli kwimizuzu emi-5 ngaphambi kokuba utofe iyeza. Sukuyitshintsha ikepusi emva kokuba uyisusile. Sukusebenzisa isirinji ukuba uyilahla phantsi.

Jonga isirinji ekhethiweyo ukuqinisekisa ukuba umhla wokuphelelwa uprintwe kwiphakheji awupasanga, ubambe isirinji ngenaliti egqunyiweyo ejonge phantsi, jonga kufutshane ulwelo kwisirinji. Ulwelo kufuneka lucace okanye lube mthubi mthubi kwaye akufuneki lubenamafu okanye lube nebala okanye lube namaqhuma okanye amasuntswana. Fowunela usokhemesti wakho ukuba kukho naziphi na iingxaki kwiphakheji okanye isirinji kwaye ungalitofisi iyeza.

Unokufaka inaliti ye-tocilizumab ngaphambili kwamathanga okanye naphina esiswini sakho ngaphandle kwenkaba yakho (iqhosha lesisu) kunye nendawo ye-intshi ezi-2 ezijikeleze yona. Ukuba omnye umntu utofa iyeza lakho, indawo engaphandle yeengalo ezingaphezulu inokusetyenziswa. Musa ukujova iyeza eluswini oluthambileyo, elityumkileyo, elibomvu, elilukhuni, okanye elingapheliyo, okanye elinamanxeba, iimolekyuli okanye imivumbo. Khetha indawo eyahlukileyo ngalo lonke ixesha utofa iyeza, ubuncinci i-intshi enye kude nendawo obukade uyisebenzisa. Ukuba idosi epheleleyo ayitofelwanga, biza ugqirha okanye usokhemesti.

Sukuyisebenzisa kwakhona iisirinji ezizalisiweyo ze-tocilizumab kwaye ungaphindi iisirinji emva kokusetyenziswa. Lahla nayiphi na isirinji esetyenzisiweyo kwisikhongozeli esinganyangekiyo kwaye ubuze usokhemesti ukuba usilahla njani isikhongozeli.

Inaliti yeTocilizumab inokunceda ukulawula iimpawu zakho, kodwa ayizukuyinyanga imeko yakho. Ugqirha wakho uyakukujonga ngononophelo ukuze ubone ukuba isebenza njani inaliti ye-tocilizumab. Ugqirha wakho unokuhlengahlengisa idosi yakho okanye alibazise unyango lwakho ukuba uneenguqu ezithile kwiziphumo zakho zelebhu. Kubalulekile ukuxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-tocilizumab,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-tocilizumab, nawaphi na amanye amayeza, okanye naziphi na izithako kwiinaliti ze-tocilizumab. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nayo nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin, Jantoven); i-aspirin kunye nezinye iziyobisi ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin, ezinye) kunye ne-naproxen (Aleve, Naprosyn, ezinye); iyeza elinciphisa i-cholesterol (ii-statins) ezinjenge-atorvastatin (Lipitor, eCaduet), lovastatin (Altoprev, kwi-Advicor), kunye ne-simvastatin (iZocor, eVytorin); izinto zokucwangcisa ngomlomo (iipilisi zolawulo lokuzalwa); okanye theophylline (Elixophyllin, Theo-24, abanye). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokuphinda asebenzisane nenaliti ye-tocilizumab, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba wakhe wanomhlaza okanye wakha wanomhlaza; i-diverticulitis (iipokotshi ezincinci kwimigca yamathumbu amakhulu anokutsha); izilonda esiswini sakho okanye emathunjini; i-cholesterol ephezulu kunye ne-triglycerides; nayiphi na imeko echaphazela inkqubo ye-nervous efana ne-multiple sclerosis (MS; isifo apho imithambo-luvo ingasebenzi kakuhle kwaye abantu banokufumana ubuthathaka, ukuba ndindisholo, ukuphulukana nokulungelelaniswa kwemisipha kunye neengxaki ngombono, intetho, kunye nolawulo lwesinyi) okanye ukudumba okungapheliyo demyelinating polyneuropathy (CIDP; ukuphazamiseka kwamasosha omzimba kunye neenkqubo zemithambo-luvo); okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa ufumana inaliti ye-tocilizumab, biza ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana inaliti ye-tocilizumab.
• buza ugqirha wakho ukuba ufanele ukufumana naluphi na ugonyo ngaphambi kokuba uqale unyango lwakho ngenaliti ye-tocilizumab. Ukuba kunokwenzeka, lonke ugonyo lwabantwana kufuneka lwenziwe ngokutsha ngaphambi kokuqala unyango. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Ukuba uphosa ixesha lokufumana i-tocilizumab infusion, tsalela ugqirha wakho.

Ukuba uyalibala ukujova idosi engaphantsi kwe-tocilizumab, jola idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukujoba idosi ephindwe kabini ukulungiselela eyilahlekileyo. Biza ugqirha wakho okanye usokhemesti ukuba awazi ukuba uza kutofa nini inaliti ye-tocilizumab.

Inaliti yeTocilizumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukuphuma empumlweni okanye ukuthimla
• ubomvu, ukurhawuzelela, iintlungu, okanye ukudumba kwindawo apho kufakwe khona i-tocilizumab

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala
• ukugungxula
• urhwebo
• ukurhawuzelela
• ukudumba kwamehlo, ubuso, imilebe, ulwimi, umqala, iingalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ubunzima bokuphefumla okanye ukugwinya
• iintlungu zesifuba
• isiyezi okanye isiqaqa
• umkhuhlane, iintlungu eziqhubekayo kwindawo yesisu, okanye utshintsho kwimikhwa yamathumbu
• Amehlo atyheli okanye ulusu; iintlungu zangaphezulu esiswini; ukugruzuka okungachazwanga okanye ukopha; ukuphelelwa ngumdla wokutya; ukudideka; umchamo omthubi okanye omdaka ngombala; okanye ilindle eliluthuthu

I-Tocilizumab inokunyusa umngcipheko wokuphuhlisa iintlobo ezithile zomhlaza. Thetha nogqirha wakho malunga neengozi zokufumana eli yeza.

Inaliti yeTocilizumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina la mayeza kwiphakeji engenileyo, kude nokukhanya, ivaliwe ngokuqinileyo, kwaye ayifumaneki ebantwaneni. Gcina inaliti ye-tocilizumab kwifriji, kodwa ungayimisi. Gcina iisirinji ezikhethwe kwangaphambili zome. Lahla naliphi na iyeza eliphelelwe lixesha okanye elingasafunekiyo. Thetha kumachiza wakho malunga nokulahla ngokufanelekileyo amayeza akho.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenaliti ye-tocilizumab.

Musa ukuvumela omnye umntu asebenzise amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Actemra^®