Inaliti yePegloticase

Umxholo

• Ngaphambi kokufumana inaliti ye-pegloticase,
• Inaliti yePegloticase inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

Inaliti yePegloticase inokubangela iimpendulo ezinzulu okanye ezisongela ubomi. Ezi mpendulo zixhaphake kakhulu kwiiyure ezimbini zokufumana ukumiliselwa kodwa zinokwenzeka nangaliphi na ixesha kunyango. Ukufakwa kufuneka kunikwe ngugqirha okanye umongikazi kwindawo yokhathalelo lwempilo apho ezi mpendulo zinokunyangwa. Unokufumana amayeza athile ngaphambi kokufakwa kwe-pegloticase ukukunceda ukuthintela impendulo. Ugqirha wakho okanye unesi uya kukujonga ngononophelo ngelixa ufumana inaliti ye-pegloticase kwaye kangangexesha elithile emva koko. Tshela ugqirha wakho ukuba unazo naziphi na kwezi mpawu zilandelayo ngexesha okanye emva kokufakwa kwakho: ubunzima bokuginya okanye ukuphefumla; ukuvutha; ukudakumba; ukudumba kobuso, umqala, ulwimi okanye imilebe; imihlathi ukuba bomvu ngequbuliso kobuso, intamo okanye isifuba esingaphezulu; irhashalala; ukurhawuzelela; ukuba bomvu kwesikhumba; isiqaqa; isiyezi; iintlungu zesifuba; okanye ukuqina kwesifuba. Ukuba ufumana impendulo, ugqirha wakho unokunciphisa okanye ayeke ukumnika.

Inaliti yePegloticase inokubangela iingxaki zegazi. Xelela ugqirha wakho ukuba une-glucose-6-phosphate dehydrogenase (G6PD) yokuswela (isifo eselifa legazi). Ugqirha wakho unokukuvavanya ukusilela kwe-G6PD ngaphambi kokuba uqale ufumane inaliti ye-pegloticase. Ukuba unesiphene se-G6PD, ugqirha wakho uya kukuxelela ukuba awunakufumana inaliti ye-pegloticase. Xelela ugqirha wakho ukuba ungowaseAfrika, kwiMeditera (kubandakanywa neYurophu eseMazantsi kunye neMbindi Mpuma), okanye imvelaphi yaseAsia eseZantsi.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwisitofu se-pegloticase kwaye unokuyeka unyango ukuba amayeza awasebenzi.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngenaliti ye-pegloticase kwaye ngalo lonke ixesha ufumana iyeza. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Inaliti yePegloticase isetyenziselwa ukunyanga igawuthi eqhubekayo (ngequbuliso, iintlungu eziqatha, ukuba bomvu, kunye nokudumba kwilungu elinye okanye nangaphezulu okubangelwa ngamanqanaba aphezulu ngokungaqhelekanga wento ebizwa ngokuba yi-uric acid egazini) kubantu abadala abangakwaziyo ukuthatha okanye abangaphendulanga kwamanye amayeza . Inaliti yePegloticase ikudidi lwamayeza abizwa ngokuba yi-PEGylated uric acid enzymes. Isebenza ngokunciphisa inani le-uric acid emzimbeni. Inaliti yePegloticase isetyenziselwa ukuthintela ukuhlaselwa yintsholongwane kodwa ingekunyangwa yakuba yenzekile.

Inaliti yePegloticase iza njengesisombululo (ulwelo) ukuze ifakwe ngaphakathi ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi kwiofisi yezonyango okanye eklinikhi. Ihlala inikwa kube kanye kwiiveki ezi-2. Kuya kuthatha ubuncinci iiyure ezi-2 zokuba ufumane idosi yakho yenaliti ye-pegloticase.

Kungathatha iinyanga ezininzi ngaphambi kokuba inaliti ye-pegloticase iqale ukuthintela ukuhlaselwa yintsholongwane. Inaliti ye-Pegloticase inokunyusa inani lokuhlaselwa kwegawuthi kwiinyanga ezintathu zokuqala zonyango lwakho. Ugqirha wakho unokumisela elinye iyeza elinje nge-colchicine okanye ichiza elichasayo (i-NSAID) ukuthintela uhlaselo lwe-gout kwiinyanga ezintandathu zokuqala zonyango lwakho. Qhubeka nokufumana inaliti ye-pegloticase nokuba uhlaselwa yi-gout ngexesha lonyango lwakho.

Pegloticase inaliti ilawula igawuthi kodwa ayiyinyangi. Qhubeka nokufumana inaliti ye-pegloticase nokuba uziva uphilile. Sukuyeka ukufumana inaliti ye-pegloticase ngaphandle kokuthetha nogqirha wakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-pegloticase,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-pegloticase, nawaphi na amanye amayeza, okanye nasiphi na isithako se-pegloticase injection. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: allopurinol (Aloprim, Lopurin, Zyloprim) kunye febuxostat (Uloric). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wasilela kwentliziyo, uxinzelelo lwegazi oluphezulu, okanye isifo sentliziyo.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa usebenzisa inaliti ye-pegloticase, tsalela ugqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inaliti yePegloticase inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• ukuqhina
• ukugruzuka
• umqala obuhkungu

Inaliti yePegloticase inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Buza usokhemesti wakho ukuba unayo nayiphi na imibuzo onayo malunga nenaliti ye-pegloticase.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Krystexxa^®