Ruxolitinib

Umxholo

• Ngaphambi kokuba uthathe i-ruxolitinib,
• I-Ruxolitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Ruxolitinib isetyenziselwa ukunyanga i-myelofibrosis (umhlaza womongo wethambo apho umongo wethambo uthatyathelwa indawo sisihlunu esibomvu kwaye kubangele ukuhla kwemveliso yeseli yegazi). Isetyenziselwa ukunyanga i-polycythemia vera (PV; umhlaza okhula kancinci egazini apho umongo wethambo wenza iiseli ezibomvu zegazi) kubantu abangakwazanga ukunyangwa ngempumelelo ngehydroxyurea. I-Ruxolitinib ikwasetyenziselwa ukunyanga isifo se-graft ngokuchasene nezifo ezisingathiweyo (i-GVHD; ingxaki ye-hematopoietic stem-cell transplant [HSCT; inkqubo ethatha indawo yomongo wethambo onesifo kunye nomongo wethambo osempilweni] kubantu abadala nakubantwana abaneminyaka eli-12 ubudala nangaphezulu abanyangwa ayiphumelelanga ngamayeza e-steroid. URuxolitinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ukunyanga i-myelofibrosis kunye ne-PV ngokuthintela imiqondiso ebangela ukuba iiseli zomhlaza zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza. Kuyasebenza ukunyanga i-GVHD ngokuthintela imiqondiso yeeseli ezibangela i-GVHD.

I-Ruxolitinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya amaxesha amabini ngemini. Thatha i-ruxolitinib malunga namaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ruxolitinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi, okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uphathwa nge-myelofibrosis okanye i-PV ugqirha wakho angakuqala kwidosi esezantsi ye-ruxolitinib kwiiveki zokuqala ezine zonyango, kwaye ngokuthe ngcembe wandise idosi yakho emva kwelo xesha, hayi ngaphezulu kwe kanye kwiiveki ezi-2. Ukuba unyangwa i-GVHD ugqirha wakho angakuqala kwidosi esezantsi ye-ruxolitinib kwaye unokunyusa idosi yakho emva kweentsuku ezi-3 zonyango.

Ginya iipilisi ngokupheleleyo; sukuzihlafuna okanye uzityumze.

Ukuba awukwazi ukutya ngomlomo kwaye unetyhubhu ye-nasogastric (NG), ugqirha wakho unokukuxelela ukuba uthathe i-ruxolitinib ngokusebenzisa ityhubhu ye-nasogastric (NG). Ugqirha wakho okanye usokhemesti uyakuchaza ukuba uyilungiselela njani i-ruxolitinib ukuba inike nge-NG ityhubhu.

Ugqirha wakho uya ku-odola uvavanyo lwegazi ngaphambi kunye nangexesha lonyango lwakho ukuze abone ukuba uchaphazeleka njani leli yeza. Ugqirha wakho unokunyusa okanye anciphise idosi yakho ye-ruxolitinib ngexesha lonyango lwakho, okanye angakuxelela ukuba uyeke ukuthatha i-ruxolitinib okomzuzwana. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza, iziphumo zovavanyo lwakho lwelebhu, kwaye ukuba uneziphumo ebezingalindelekanga. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka nokuthatha i-ruxolitinib nokuba uziva uphilile. Sukuyeka ukuthatha i-ruxolitinib ngaphandle kokuthetha nogqirha wakho. Ukuba ugqirha wakho uthatha isigqibo sokuyeka unyango lwakho nge-ruxolitinib, ugqirha wakho unokunciphisa idosi yakho ngokuthe ngcembe.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-ruxolitinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-ruxolitinib, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwi-ruxolitinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amayeza okubulala ukubola kubandakanya itraconazole (Sporanox), ketoconazole, kunye ne-voriconazole (Vfend); carbamazepine (Carbatrol, Equetro, Tegretol, nabanye); I-clarithromycin; efavirenz (Sustiva, eAtripla, eSymfi); i-fluconazole (iDiflucan); I-HIV protease inhibitors kubandakanya indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e Kaletra, Viekira Pak), kunye ne-saquinavir (Invirase); mibefradil (Posicor); nefazodone; nevirapine (Viramune); phenytoin (iDilantin, iPhenytek); ipioglitazone (iActos, eOseni, iDuetact); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane, eRifamate, Rifater); iTelaprevir (Incivik); kunye ne-telithromycin (Ketek). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.Amanye amayeza amaninzi anokusebenzisana ne-ruxolitinib, ke qiniseka ukuxelela ugqirha wakho malunga nawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unayo i-anemia, usulelo, ukuba unesifo se-dialysis, okanye ukuba ubusandul 'ukudibana nomntu onesifo sephepha (i-TB, isifo esosulelayo semiphunga) okanye otyeleleyo okanye ohlala apho ixhaphake kakhulu i-TB. Xelela ugqirha wakho ukuba unayo okanye wakhe wanesifo sephepha, i-cholesterol ephezulu, umhlaza wolusu, i-hepatitis B okanye esinye isifo sesibindi, okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa uthatha i-ruxolitinib, biza ugqirha wakho. Akufanelanga ukuncancisa ngelixa uthatha i-ruxolitinib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ruxolitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isiyezi
• intloko ebuhlungu
• ukudinwa
• ubuthathaka
• ukuqhawukelwa ngumphefumlo
• ukutyeba kwakho
• irhasi
• intlungu zesisu
• urhudo
• ukuqhina
• isicaphucaphu
• ukurhawuzelela
• irhashalala
• intlungu yesihlunu okanye edibeneyo
• ukudumba kweengalo, imilenze okanye amanye amalungu omzimba

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukopha okungaqhelekanga okanye okunzima okanye ukugruzuka
• umkhuhlane, umqala obuhlungu, ukugodola, ukukhohlela, iintlungu esifubeni, ukubila ebusuku, rhoqo, kubuhlungu, ukuchama ngokungxamisekileyo, kunye nezinye iimpawu zosulelo
• ukutshisa, ukurhawuzelela, ukurhawuzelela, okanye ubuntununtunu bolusu kwelinye icala lomzimba okanye ubuso ngokurhabaxa okubuhlungu okanye iblisters ezibonakala emva kweentsuku ezininzi.
• izilonda ezintsha, amaqhuma, okanye umbala okanye olunye utshintsho kwesikhumba
• ulusu olumhlophe, ukudinwa, okanye ukuphefumla okufutshane (ngakumbi ngelixa uzilolonga)
• ubunzima bokuhambisa okanye ukugcina ulungelelwaniso, ubuthathaka bemilenze okanye iingalo eziqhubeka zisiba mbi, ubunzima bokuqonda okanye ukuthetha, ukulahleka kwememori, iingxaki zombono, okanye utshintsho kubuntu

I-Ruxolitinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukopha okungaqhelekanga okanye ukugruzuka
• isiyezi
• intloko ebuhlungu
• ukudinwa
• umkhuhlane, umqala obuhlungu, Ukugodola, ukukhohlela, kunye neminye imiqondiso yosulelo

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Jakafi