Vemurafenib

Umxholo

• Ngaphambi kokuba uthathe vemurafenib,
• I-Vemurafenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Ukuba ufumana naziphi na kwezi mpawu zilandelayo zokungalungelani okanye ulusu olunamandla, yeka ukuthatha i-vemurafenib kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

I-Vemurafenib isetyenziselwa ukunyanga iintlobo ezithile ze-melanoma (uhlobo lomhlaza wolusu) ongenakunyangwa ngoqhaqho okanye osasazeke kwamanye amalungu omzimba. Isetyenziselwa ukunyanga uhlobo oluthile lwe-Erdheim-Chester isifo (i-ECD; isifo esibangela ukuveliswa ngokugqithisileyo kohlobo lweeseli ezimhlophe zegazi). UVemurafenib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

IVemurafenib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kabini ngemini, kusasa nangokuhlwa, malunga neeyure ezili-12 ukwahlukana. Thatha vemurafenib ngeenxa zonke ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha vemurafenib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho. Sukuyeka ukuthatha vemurafenib ungakhange uthethe nogqirha wakho.

Ginya iipilisi ngokupheleleyo ngeglasi yamanzi; sukuzihlafuna okanye uzityumze.

Ukuba uyagabha emva kokuba uthathe i-vemurafenib, sukuthatha kwangoko enye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho kusenokufuneka ayeke okwexeshana okanye ngokusisigxina unyango lwakho okanye anciphise idosi yemururenen ngexesha lonyango lwakho oku kuxhomekeke ekubeni lisebenza njani na iyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho kunye ne-vemurafenib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango ngeemurafenib kwaye ngalo lonke ixesha uzalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe vemurafenib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-vemurafenib, nawaphi na amanye amayeza, okanye ezinye izithako ezikwiipilisi ze-vemurafenib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: i-clarithromycin (i-Biaxin, kwi-PrevPac); amayeza athile kwintsholongwane kaGawulayo (i-HIV) okanye i-immunodeficiency syndrome (i-AIDS) efana ne-indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, e-Kaletra), kunye ne-saquinavir (i-Invirase); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, kunye phenytoin (Dilantin, Phenytek); nefazodone; irifampin (Rifadin, Rimactane, eRifamate, eRifater); tizanidine; kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokuphinda asebenzisane ne-vemurafenib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba wakhe wanalo naluphi na uhlobo lomhlaza wolusu; ixesha elide leQT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe); ukumelwa yintliziyo; inqanaba eliphantsi le-calcium, i-magnesium, okanye i-potassium egazini lakho; Intliziyo, isifo, okanye isifo sesibindi. Kwakhona xelela ugqirha wakho ukuba unayo okanye uceba ukufumana unyango ngemitha.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-vemurafenib. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye ne-vemurafenib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha vemurafenib, tsalela ugqirha wakho. I-Vemurafenib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufuneki uncancise ngelixa uthatha i-vemurafenib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya nonyango lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha vemurafenib.
• cwangcisa ukuthintela ukukhanya elangeni okungeyomfuneko okanye ixesha elide kunye nokunxiba impahla ekhuselayo, iiglasi zelanga, i-lip balm kunye ne-sunscreen (i-SPF 30 okanye ngaphezulu). I-Vemurafenib inokwenza ulusu lwakho lubuthathaka kwilanga.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba ngaba ngaphakathi kweeyure ezingama-4 zedosi yakho ehleliweyo elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Vemurafenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudinwa
• ngokudibeneyo, umsipha, ingalo, umlenze, okanye iintlungu zomqolo
• ububomvu okanye ukudumba ezandleni, iinyawo, amaqatha, okanye imilenze esezantsi
• utshintsho ngengqondo yokungcamla
• intloko ebuhlungu
• ukulahleka kweenwele
• ulusu olomileyo okanye olurhawuzayo
• urhudo
• ukuqhina
• ukukhohlela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• utshintsho kwinkangeleko yesikhumba
• intsumpa entsha
• ulusu lubuhlungu okanye iqhuma elibomvu elopha okanye lingapholi
• utshintsho kubungakanani okanye umbala kwimole
• ukudinwa kakhulu
• ukugruzuka okanye ukopha okungaqhelekanga
• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• iintlungu kwinxalenye ephezulu yesisu
• mthubi ulusu okanye amehlo
• ubuntununtunu bamehlo ekukhanyeni
• ubomvu wamehlo okanye iintlungu
• utshintsho lombono
• ukuqina okungaqhelekanga kwezandla
• Ukuqiniswa kweminwe ngaphakathi ngaphakathi entendeni
• ukuqina okungaqhelekanga kweenyawo, ezinokuba buhlungu

Ukuba ufumana naziphi na kwezi mpawu zilandelayo zokungalungelani okanye ulusu olunamandla, yeka ukuthatha i-vemurafenib kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ubunzima bokuphefumla okanye ukugwinya
• ukukhawuleza, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• isiqaqa
• irhashalala okanye ukuba bomvu emzimbeni wonke
• urhwebo
• Ukuxobuka okanye ukudumba kolusu
• ifiva

IVemurafenib inokunyusa umngcipheko wokuba uphuhlise eminye imihlaza. Thetha nogqirha wakho malunga nale ngozi.

I-Vemurafenib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwimururafenib. Ugqirha wakho uza kujonga ulusu lwakho ngaphambi kokuqala unyango, rhoqo kwiinyanga ezi-2 ngexesha lonyango, kwaye ukuya kuthi ga kwiinyanga ezi-6 emva konyango.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Zelboraf^®