Ivacaftor

Umxholo

• Ngaphambi kokuba uthathe ivacaftor,
• I-Ivacaftor inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Ivacaftor isetyenziselwa ukunyanga iintlobo ezithile ze-cystic fibrosis (isifo esizalwe naso esidala iingxaki ngokuphefumla, ukwetyisa, kunye nokuzala) kubantu abadala kunye nabantwana abane iinyanga ezi-4 ubudala nangaphezulu. I-Ivacaftor kufuneka isetyenziswe kuphela kubantu abanemveliso ethile yobume. Ugqirha wakho unokuyalela uvavanyo lwegazi ukukunceda uthathe isigqibo sokuba ngaba eliyeza lilungile na kuwe. I-Ivacaftor ikudidi lwamayeza abizwa ngokuba yi-cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Isebenza ngokuphucula ukusebenza kweprotein emzimbeni ukunciphisa ukwakhiwa kwe-mucus eshinyeneyo emiphungeni kunye nokuphucula ezinye iimpawu ze-cystic fibrosis.

I-Ivacaftor iza njengecwecwe kwaye njengegranules yokuthatha ngomlomo. Ihlala ithathwa ngokutya okunamafutha kabini ngemini, ngaphandle kweeyure ezili-12. Thatha i-ivacaftor ngeenxa zonke ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ivacaftor ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukulungiselela idosi ye-ivacaftor granules, xuba yonke ipakethi yegranu kwitispuni ye-1 (5 ml) yengqele okanye igumbi lobushushu ukutya okuthambileyo okanye ulwelo olufana neyogathi, iapile, amanzi, ubisi, ubisi olungumgubo losana, ubisi lwebele, okanye ijusi. Thatha umxube ngaphakathi kweyure eli-1 lokuxuba iigraanu kunye nokutya okanye ulwelo.

Thatha idosi nganye ye-ivacaftor ngokutya okunamafutha okufana namaqanda, ibhotolo, ibhotolo yamandongomane, itshizi pizza, iimveliso zobisi olupheleleyo (ezinje ngobisi olupheleleyo, itshizi, kunye neyogathi), ifomula yosana, kunye nobisi lwebele. Thetha nogqirha wakho malunga nokunye ukutya okunamafutha okutya kunye ne-ivacaftor.

I-Ivacaftor ilawula i-cystic fibrosis kodwa ayiyinyangi. Qhubeka nokuthatha ivacaftor nokuba uziva uphilile. Sukuyeka ukuthatha ivacaftor ungakhange uthethe nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe ivacaftor,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-ivacaftor, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-ivacaftor. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, othabathayo okanye oceba ukuthatha Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: ii-antibiotics ezithile ezifana ne-clarithromycin (i-Biaxin, kwi-PrevPac), i-erythromycin (i-EES, i-E-Mycin, i-Ery-Tab, i-Erythrocin), kunye ne-telithromycin (Ketek); ii-antifungals ezithile ezinjenge fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne voriconazole (Vfend); icyclosporine (Gengraf, Neoral, Sandimmune); idigoxin (Lanoxin); amayeza athile okubanjwa njenge-carbamazepine (Carbatrol, Epitol, Tegretol, abanye), phenobarbital, kunye phenytoin (Dilantin, Phenytek); midazolam; irifabutin (Mycobutin); irifampin (Rifadin, eRifamate, eRifater, eRimactane); itacrolimus (Astagraf, Prograf), okanye warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-ivacaftor, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwe ngelixa uthatha ivacaftor, tsalela ugqirha wakho.
• Kuya kufuneka uyazi ukuba ivacaftor inokukwenza ube nesiyezi. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Musa ukuyitya i-grapefruit okanye ii-orenji ze-Seville okanye usele ijusi ye-grapefruit ngelixa uthatha eli yeza.

Ukuba ukhumbula idosi ephosiweyo kwisithuba seeyure ezingama-6 zexesha owawucwangciselwe ukulithatha, thatha idosi ephosiweyo kwangoko kunye nokutya okunamafutha. Nangona kunjalo, ukuba ngaphezulu kweeyure ezingama-6 zidlulile ukusukela kwixesha elimiselweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ivacaftor inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• irhashalala
• intlungu edibeneyo
• umlomo nomqala obuhlungu
• umkhuhlane, umqala obuhlungu, ukuphuma kwempumlo, okanye ezinye iimpawu zosulelo
• urhudo
• isiyezi

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya
• iintlungu kwinxalenye ephezulu yesisu
• umchamo omnyama
• ukudinwa kakhulu
• ukopha okungaqhelekanga okanye ukugruzuka
• mthubi ulusu okanye amehlo
• utshintsho lombono

I-Ivacaftor inokuwonyusa umngcipheko wokuba wena okanye umntwana wakho unokuhlakulela i-cataract. Thetha nogqirha wakho okanye ugqirha womntwana wakho malunga neengozi zokuthatha la mayeza.

I-Ivacaftor inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isiyezi
• urhudo

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuku-odola kuvavanyo lwamehlo kunye novavanyo oluthile lwelebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-ivacaftor.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Kalydeco^®