ICabozantinib (umhlaza wedlala lengqula)

Umxholo

• Ngaphambi kokuba uthathe i-cabozantinib (Cometriq),
• ICabozantinib (Cometriq) inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Cabozantinib (Cometriq) isetyenziselwa ukunyanga uhlobo oluthile lomhlaza we-thyroid oqhubeka usiba nzima kwaye usasazeke kwamanye amalungu omzimba. ICabozantinib (Cometriq) ikwiklasi yamayeza abizwa ngokuba yi-tyrosine kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Cabozantinib ikwafumaneka njengepilisi (i-Cabometyx) ukunyanga i-renal cell carcinoma (RCC; uhlobo lomhlaza oqala kwiiseli zezintso) kunye ne-hepatocellular carcinoma (HCC; uhlobo lomhlaza wesibindi) kwizigulana ezithile esele zikhona waphathwa ngelinye iyeza. Le monograph inika kuphela ulwazi malunga necabozantinib capsules (Cometriq) yomhlaza wedlala lengqula. Ukuba usebenzisa eli yeza kwi-RCC ephezulu okanye kwi-HCC, funda i-monograph enesihloko esithi cabozantinib (umhlaza wesibindi nowezintso).

ICabozantinib (Cometriq) iza njengecapsule ukuba ithathe ngomlomo. Kuthathwa rhoqo kanye ngemini kwisisu esingenanto, ubuncinci iyure enye ngaphambi kunye neeyure ezi-2 emva kokutya. Thatha i-cabozantinib (Cometriq) ngexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-cabozantinib (Cometriq) ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gwinya zonke iifomsile ngeglasi epheleleyo (ii-ounces eziyi-8, i-240 mL) yamanzi. Sukuzivula.

Ugqirha wakho unokunciphisa idosi yakho ye-cabozantinib (Cometriq) okanye ngokusisigxina okanye okwexeshana uyeke unyango lwakho ukuba uneziphumo ebezingalindelekanga ezibi. Qiniseka ukuba uthethe nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho nge-cabozantinib (Cometriq).

Ubude bonyango lwakho buxhomekeke kwindlela ophendula ngayo kunyango kunye neziphumo ozifumanayo. Qhubeka uthathe i-cabozantinib (Cometriq) nokuba uziva uphilile. Sukuyeka ukuthatha i-cabozantinib (Cometriq) ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-cabozantinib (Cometriq),

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-cabozantinib (i-Cabometyx, i-Cometriq), nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-capsules ze-cabozantinib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: adefovir (Hepsera); izinto zokubulala ezinje nge-itraconazole (Sporanox), ketoconazole, kunye ne-voriconazole (Vfend); i-clarithromycin (i-Biaxin, kwi-Prevpac); dexamethasone; i-furosemide (iLasix); amayeza athile e-HIV okanye i-AIDS afana ne-abacavir (Ziagen), atazanavir (Reyataz), cidofovir, indinavir (Crixivan), lamivudine (Epivir, e-Combivir); nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, eKaletra), saquinavir (Invirase), kunye ne-tenofovir (Viread); amayeza athile okubanjwa njenge-carbamazepine (i-Equetro, iTegretol, iTeril), i-phenobarbital, kunye ne-phenytoin (iDilantin, Phenytek); nefazodone; probenecid (Probalan), rifabutin (Mycobutin); irifampin (Rifactin, Rifadin, eRifamate, eRifater); irifapentine (Priftin); telithromycin (Ketek); kunye ne-warfarin (Coumadin, Jantoven). Uninzi lwamanye amayeza anokusebenzisana necabozantinib (Cometriq), ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akujonge ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ubusandula ukopha ngokungaqhelekanga okanye ukukhwehlela igazi, ukugabha igazi, okanye isitulo segazi okanye esimnyama sokulinda. Xelela ugqirha wakho ukuba unenxeba elivulekileyo okanye eliphilisayo, okanye ukuba unayo okanye ukhe waba noxinzelelo lwegazi oluphezulu okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango nge-cabozantinib. Akufanele ukhulelwe ngexesha lonyango lwakho kunye ne-cabozantinib kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwa ngelixa uthatha i-cabozantinib (Cometriq), biza ugqirha wakho ngokukhawuleza. ICabozantinib inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Ugqirha wakho unokukuxelela ukuba ungancancisi ngexesha lonyango lwakho kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga neengozi zokuthatha i-cabozantinib (Cometriq).
• ukuba uyenziwa utyando, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-cabozantinib (Cometriq). Ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-cabozantinib (Cometriq) ubuncinci kwiintsuku ezingama-21 ngaphambi kotyando lwakho kwaye uya kukuxelela xa kufuneka uqale ukuthatha amayeza kwakhona emva kotyando lwakho.
• Kuya kufuneka uyazi ukuba i-cabozantinib (Cometriq) inokubangela iingxaki ezinzulu ngomhlathi wakho. Ugqirha wamazinyo kufuneka ahlolisise amazinyo akho ngaphambi kokuba uqale ukuthatha i-cabozantinib kwaye rhoqo ngexesha lonyango lwakho. Qiniseka ukuba uhlamba amazinyo kwaye ucoce umlomo wakho ngokufanelekileyo ngelixa uthatha i-cabozantinib (Cometriq). Thetha nogqirha wakho ngaphambi kokuba ufumane unyango lwamazinyo ngelixa uthatha eli yeza. Ugqirha wakho uya kukuxelela ukuba uyeke ukuthatha i-cabozantinib ubuncinci kwiintsuku ezingama-21 ngaphambi kotyando lwamazinyo.
• Kuya kufuneka uyazi ukuba uxinzelelo lwegazi lwakho lunokunyuka ngexesha lonyango lwakho nge-cabozantinib (Cometriq). Ugqirha wakho uya kuthi abeke esweni uxinzelelo lwegazi ngexesha lonyango lwakho.

Musa ukusela ijusi yegrapefruit okanye utye iidiliya okanye nantoni na yokutya okanye izongezo eziqukethe iidiliya okanye ijusi yegrapefruit ngelixa uthatha eliyeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 kude kube yidosi elandelayo ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

ICabozantinib (Cometriq) inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuqhina
• Iimpawu
• isicaphucaphu
• ukugabha
• isilungulela
• utshintsho kwisakhono sokungcamla ukutya
• kunzima ukugwinya
• ubomvu, ukudumba, izilonda, okanye iintlungu emlonyeni okanye emqaleni
• Ukuphelelwa ngumdla wokutya
• ukuhla ukusinda
• ukudinwa okanye ubuthathaka
• iintlungu kumalungu
• iintlungu zemisipha okanye ukudumba
• ixhala
• ukuba ndindisholo, ukutshisa, okanye ukurhawuzelela izandla, iingalo, iinyawo okanye imilenze
• isikhumba esomileyo
• ukuqina okumnyama kolusu
• ukulahleka kweenwele
• umbala weenwele ojika ukhaphuke okanye ube ngwevu
• Ukutshintsha kwelizwi okanye ukungxola

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukukhohlela igazi okanye amahlwili egazi
• ukugabha okunento enegazi okanye okufana nekofu
• ukuphuma kwegazi okunzima kunesiqhelo
• obomvu okanye omnyama, isitulo sokulinda
• nakuphi na ukopha okungafunekiyo okanye okunzima okanye ukugruzuka
• urhudo
• indawo yesisu ethambileyo okanye ebuhlungu
• ukudumba okanye iintlungu ezingalweni okanye emilenzeni
• ukuqhawukelwa ngumphefumlo
• intloko elula okanye etyhafayo
• ukubila
• Ukuba ndindisholo okanye ukuba buthathaka kobuso, ingalo, okanye umlenze kwelinye icala lomzimba wakho
• isiyezi
• ubunzima ngequbuliso ngokulingana okanye ngokulungelelanisa
• Iintsini ezidumbileyo okanye ezibuhlungu
• ngequbuliso, intloko ebuhlungu
• iintlungu zomhlathi
• Lizinyo
• ukuxhuzula
• ukuhamba ngesiquphe
• iingxaki zombono ngesiquphe
• ukudideka
• ubunzima ngesiquphe bokucinga okanye ukuthetha ngokucacileyo
• irhashalala
• ubomvu, iintlungu, ukudumba, okanye ukudumba ezintendeni okanye ematheni
• ubunzima bokutya okanye ukusela ngenxa yezilonda zomlomo okanye isicaphucaphu kunye nokugabha

ICabozantinib (Cometriq) inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo.http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukulahleka kwememori
• ukudideka
• ukuhla ukusinda

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwi-cabozantinib (Cometriq).

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• ICometriq^®