Dabrafenib

Umxholo

• Ngaphambi kokuba uthathe i-dabrafenib,
• I-Dabrafenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza:

I-Dabrafenib isetyenziswa yodwa okanye idityaniswe ne-trametinib (i-Mekinist) ukunyanga iintlobo ezithile ze-melanoma (uhlobo lomhlaza wolusu) olungenakunyangwa ngoqhaqho okanye oluye lwasasazeka kwamanye amalungu omzimba. Isetyenziswa kunye ne-trametinib ukunyanga kunye nokuthintela ukubuya kohlobo oluthile lwe-melanoma emva kotyando ukuyisusa kunye naziphi na ii-lymph node ezichaphazelekayo. I-Dabrafenib ikwasetyenziswa ngokudibeneyo ne-trametinib ukunyanga uhlobo oluthile lomhlaza wesifo somhlaza wamaphaphu ongekho mncinci (NSCLC) osasazeke kwizicwili ezikufutshane okanye kwamanye amalungu omzimba. Isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wedlala lengqula oluye lwasasazeka kwizicwili ezikufutshane okanye kwamanye amalungu omzimba angakhange aphendule kunyango lwangaphambili. UDabrafenib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

I-Dabrafenib iza njengecapsule ukuthatha ngomlomo. Ihlala ithathwa kabini ngemini kwisisu esingenanto, iyure e-1 ngaphambi okanye iiyure ezi-2 emva kwesidlo. Thatha i-dabrafenib malunga neeyure ezili-12 ngaphandle ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-dabrafenib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho. Sukuyeka ukuthatha i-dabrafenib ngaphandle kokuthetha nogqirha wakho.

Ginya zonke iifomsile; sukuzivula, uzaphule, okanye uzityumze.

Ugqirha wakho unokuhlengahlengisa idosi yakho okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-dabrafenib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-dabrafenib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-dabrafenib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiifomsile ze-dabrafenib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: clarithromycin (Biaxin, kwi-PrevPac); dexamethasone; gemfibrozil (iLopid); ketoconazole; midazolam; nefazodone; irifampin (Rifadin, eRifamate, eRifater, eRimactane); kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-dabrafenib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba ukhe unesifo seswekile; Iswekile yeglucose-6-phosphate dehydrogenase (G6PD) (imeko yemfuza); iingxaki zokopha; iingxaki zamehlo; ukusilela kwentliziyo okanye ezinye iingxaki zentliziyo; isibindi okanye isifo sezintso; okanye nayiphi na imeko yezonyango.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa, okanye ukuba ucwangcisa ukuba notata umntwana. Ukuba ungowasetyhini, kuya kufuneka ukuba ube novavanyo lokukhulelwa ngaphambi kokuba uqale unyango, kwaye kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango kunye nakwiiveki ezi-2 emva kwedosi yakho yokugqibela. Ukuba uyindoda kwaye iqabane lakho lingakhulelwa, kuya kufuneka usebenzise ikhondom ngelixa uthatha eli yeza, kunye neeveki ezi-2 emva konyango lwakho, nokuba une-vasectomy (utyando ukunqanda isidoda ukuba singaphumi emzimbeni wakho kwaye sibangele ukukhulelwa) . Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini; Nangona kunjalo, akufuneki ucinge ukuba awungekhe ukhulelwe okanye awungekhe umithise omnye umntu. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha i-dabrafenib, biza ugqirha wakho. I-Dabrafenib inokulimaza umbungu.
• Kuya kufuneka uyazi ukuba i-dabrafenib inokunciphisa ukusebenza kwezicwangcisi zehomoni (iipilisi zokulawula ukuzalwa, iipatches, iiringi, izinto zokufakelwa kunye nenaliti). Kuya kufuneka usebenzise enye indlela yolawulo lokuzalwa ukukhusela ukukhulelwa kuwe okanye kwiqabane lakho ngexesha lonyango lwakho kunye ne-dabrafenib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-dabrafenib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-dabrafenib.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba ingaphantsi kweeyure ezingama-6 de idosi yakho ehleliweyo elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Dabrafenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ngokudibeneyo, umsipha, okanye iintlungu zomqolo
• isicaphucaphu
• urhudo
• ukuqhina
• Ukuphelelwa ngumdla wokutya
• ukukhwehlela, ukuphuma kwempumlo, okanye umqala obuhlungu
• ukulahleka kweenwele
• ukudinwa

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza:

• Utshintsho kulusu (intsumpa entsha, isikhumba esibuhlungu, okanye iqhubu elibomvu elopha okanye lingaphilisi)
• utshintsho kubungakanani okanye umbala kwimole
• irhashalala, isikhumba esibomvu, okanye amaqhakuva
• ifiva
• isiqaqa
• utywala, intloko, okanye ubuthathaka
• Ukugodola
• ukuncipha kokuchama
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukuchama rhoqo
• ukwanda kokoma
• iintlungu zamehlo
• iinkophe ezibomvu okanye ezidumbileyo
• uvakalelo ekukhanyeni
• ukungaboni kakuhle okanye utshintsho lombono, kubandakanya ukubona iihalos (ulwandlalo olungqongqo ujikeleze izinto) okanye amachaphaza anemibala
• ukudumba, iintlungu, ukuba bomvu, okanye ukuxobuka kolusu ezintendeni zeenyawo
• iintlungu eziqhubekayo eziqala kwindawo yesisu kodwa zinokusasazeka ngasemva
• ukopha okungaqhelekanga okanye ukugruzuka
• enegazi okanye emnyama, ilindle
• ukukhohlela okanye ukugabha igazi okanye into ebonakala ngathi yindawo yekhofi
• iintlungu zesifuba
• ukuqhawukelwa ngumphefumlo
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• ngokukhawuleza, ngokungaqhelekanga, okanye ukubetha kwentliziyo
• ubumthubi besikhumba namehlo

I-Dabrafenib inokunyusa umngcipheko wokuba uza kuphuhlisa umhlaza wolusu omtsha okanye eminye imihlaza. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Dabrafenib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-dabrafenib. Ugqirha wakho uya ku-odola iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-dabrafenib. Ugqirha wakho uya kujonga ulusu lwakho kulo naluphi na utshintsho ngaphambili, rhoqo kwiinyanga ezi-2 ngexesha lonyango lwakho, kwaye ukuya kuthi ga kwiinyanga ezi-6 emva konyango.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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