Itrametinib

Umxholo

• Ngaphambi kokuba uthathe i-trametinib,
• I-Trametinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, yeka ukuthatha i-trametinib kwaye ubize ugqirha ngoko nangoko:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Trametinib isetyenziswa yodwa okanye idityaniswe ne-dabrafenib (Tafinlar) ukunyanga iintlobo ezithile ze-melanoma (uhlobo lomhlaza wolusu) olungenakunyangwa ngoqhaqho okanye oluye lwasasazeka kwamanye amalungu omzimba. Isetyenziswa ngokudibeneyo ne-dabrafenib ukunyanga kunye nokuthintela ukubuya kohlobo oluthile lwe-melanoma emva kotyando ukuyisusa kunye naziphi na ii-lymph node ezichaphazelekayo. I-Trametinib ikwasetyenziswa ngokudibeneyo ne-dabrafenib ukunyanga uhlobo oluthile lomhlaza wamaphaphu ongekho mncinci (NSCLC) osasazeke kwizicwili ezikufutshane okanye kwamanye amalungu omzimba. Isetyenziswa ngokudibeneyo ne-dabrafenib ukunyanga uhlobo oluthile lomhlaza we-thyroid osasazeke kwizicubu ezikufutshane okanye kwamanye amalungu omzimba, angenakuphathwa ngezinye iindlela zonyango. I-Trametinib ikwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

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I-Trametinib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kwisisu esingenanto, ubuncinci iyure enye ngaphambi okanye iiyure ezi-2 emva kwesidlo. Thatha i-trametinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-trametinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho. Ungayeki ukuthatha i-trametinib ngaphandle kokuthetha nogqirha wakho.

Ugqirha wakho unokuhlengahlengisa idosi yakho yetrametinib kuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-trametinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-trametinib, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-trametinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha.
• xelela ugqirha wakho ukuba ukhe unesifo semiphunga okanye uneengxaki zokuphefumla; isifo seswekile; iingxaki zokopha okanye amahlwili egazi; isifo sokudumba (ukudumba koloni); iingxaki zesisu; igazi elonyukayo; Intliziyo, iliso, isibindi, okanye isifo sezintso; okanye ezinye iimeko zonyango.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-trametinib. Kuya kufuneka usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye ne-trametinib kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-trametinib, biza ugqirha wakho. I-Trametinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa okanye ucwangcisa ukuncancisa. Akufanele uncelise ngelixa uthatha i-trametinib kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma kubafazi. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-trametinib.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 kude kube yidosi elandelayo ehleliweyo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Trametinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isikhumba esomileyo
• izilonda emlonyeni naselulwimini
• umlomo owomileyo
• ukugabha
• Ukuphelelwa ngumdla wokutya
• utshintsho kwisakhono sokungcamla ukutya
• ukudinwa

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu, yeka ukuthatha i-trametinib kwaye ubize ugqirha ngoko nangoko:

• ukopha okungaqhelekanga okanye ukugruzuka
• enegazi okanye emnyama, ilindle
• ukukhohlela okanye ukugabha igazi okanye into ebonakala ngathi yindawo yekhofi
• impumlo
• urhudo oluqatha
• isisu esibuhlungu
• isicaphucaphu
• ifiva
• Ukugodola
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• ubunzima bokuphefumla
• iintlungu zesifuba
• ukudumba kobuso, iingalo, imilenze, amaqatha okanye iinyawo
• utywala, intloko, okanye ubuthathaka
• ukuqhawukelwa ngumphefumlo
• iintlungu zomlenze, ukudumba, ukuthamba, ubomvu, okanye ukufudumala
• intloko ebuhlungu
• ukukhohlela
• ukungaboni kakuhle
• Utshintsho kumbono, kubandakanya ukubona ii-halos (ulwandlalo olungqongqo ujikeleze izinto) okanye amachaphaza anemibala
• ukulahleka kombono
• iintlungu zamehlo
• amehlo owomileyo, abomvu, okanye adumbileyo
• irhashalala, isikhumba esibomvu, okanye amaqhakuva
• intsumpa
• iqhuma elibomvu elopha okanye lingapholi
• utshintsho kubungakanani okanye umbala kwimole
• ukurhawuzelela
• amadyunguza, izilonda, okanye izilonda kulusu okanye kwiinzipho
• ukurhawuzelela, ukutshisa, ukuba bomvu, ukudumba, ukuxobuka okanye ukubhabha, iblisters, okanye izilonda ezintendeni zezandla okanye ezintendeni zeenyawo
• ukuchama rhoqo
• ukwanda kokoma

I-Trametinib inokunyusa umngcipheko wokuba uza kuphuhlisa umhlaza wolusu okanye eminye imihlaza. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Trametinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile ngaphakathi, livalwe ngokuqinileyo, kude ukufuma kunye nokukhanya, kwaye kude nokufikelela kwabantwana. Musa ukubeka iipilisi kwezinye izikhongozeli, ezinje ngeebhokisi zepilisi zemihla ngemihla okanye zeveki. Yigcine kwisikhenkcisi, kodwa musa ukuyenza ngumkhenkce. Musa ukuyisusa i-desiccant (ipakethi encinci ebandakanyiwe kunye namayeza okufunxa ukufuma) kwibhotile yakho.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• iingxaki zombono

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukuze abone ukuba kukhuselekile na kuwe ukufumana itrametinib kwaye ujonge impendulo yomzimba wakho kwitrametinib. Ugqirha wakho uya kujonga ulusu lwakho kulo naluphi na utshintsho ngaphambi kokuba uqale unyango, rhoqo kwiinyanga ezi-2 ngexesha lonyango lwakho, kwaye ukuya kuthi ga kwiinyanga ezi-6 emva konyango. Ugqirha wakho uya kujonga uxinzelelo lwegazi amaxesha ngamaxesha njengoko kufuneka.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Mekinist^®