Ibrutinib

Umxholo

• Ibrutinib isetyenziswa:
• Ngaphambi kokuba uthathe ibrutinib,
• Ibrutinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

Ibrutinib isetyenziswa:

• ukunyanga abantu abane-mantle cell lymphoma (i-MCL; umhlaza okhula ngokukhawuleza oqala kwiiseli zamasosha amajoni omzimba) esele baphathwa ngamanye amayeza e-chemotherapy,
• ukunyanga abantu abane-lymphocytic leukemia (CLL; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) kunye ne-lymphocytic lymphoma (SLL; uhlobo lomhlaza oqala ikakhulu kwii-lymph node),
• ukunyanga abantu abane-Waldenstrom's macroglobulinemia (WM; umhlaza okhula kancinci oqala kwiiseli ezithile ezimhlophe zomongo wethambo)
• Ukunyanga abantu abane-lymphoma zone marginal (MZL; umhlaza okhula kancinci oqala kuhlobo lweeseli ezimhlophe zegazi ezilwa nosulelo) esele ziphathwe ngohlobo oluthile lwamayeza e-chemotherapy,
• kunye nokunyanga abantu abanesifo esinganyangekiyo sokudityaniswa kwentsholongwane (i-cGVHD; ingxaki ye-hematopoietic stem-cell transplant [HSCT; inkqubo ethatha indawo yomongo wethambo onesifo nomongo wethambo osempilweni] enokuthi iqale okwethutyana emva kokufakelwa ize ihlale ixesha elide ) emva kokuphathwa ngokungaphumeleli nge-1 okanye ngaphezulu amayeza.

U-Ibrutinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukunqanda ukusasazeka kweeseli zomhlaza.

Ibrutinib iza njengephilisi kunye necwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye yonke imihla. Thatha ibrutinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha ibrutinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya i njengezingxobo iphela ngeglasi yamanzi; sukuzivula, ungaqhekezi, okanye uzihlafune. Ginya i iipilisi iphela ngeglasi yamanzi; sukuzisika, uzityumze okanye uzihlafune.

Ukuba ufumana inaliti ye-obinutuzumab (Gazyva) okanye i-rituximab (Rituxan), ugqirha unokukuxelela ukuba uthathe idosi yakho ye-imbrutinib ngaphambi kokuba ufumane inaliti yakho.

Ugqirha wakho unokunciphisa idosi yakho, okanye uphazamise okanye uyeke ukuhambisa kwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Qhubeka uthathe ibrutinib nokuba uziva uphilile. Sukuyeka ukuthatha ibrutinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe ibrutinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-ibrutinib, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwii-capsules ze-ibrutinib okanye iipilisi. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-anticoagulants ('i-blood thinner') efana ne-warfarin (Coumadin, Jantoven); ii-antifungals ezinjenge fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne voriconazole (Vfend); amayeza antiplatelet anje ngeclopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta), kunye ticlopidine; Aprepitant (Hlomela); carbamazepine (Carbatrol, Epitol, Tegretol, Teril); i-clarithromycin (i-Biaxin, i-Prevpac), i-digoxin (i-Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nabanye); i-erythromycin (i-EES, i-Erythrocin, abanye), amayeza athile okunyanga intsholongwane kaGawulayo okanye isifo se-immunodeficiency syndrome (i-AIDS) njenge-efavirenz (Sustiva, e-Atripla), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), kunye ne-saquinavir (i-Invirase); imethotrexate (Otrexup, Rasuvo, Trexall, Xatmep); nefazodone; phenytoin (iDilantin, iPhenytek); rifampin (Rifadin, Rifamate, Rimactane, nabanye); i-verapamil (Calan, Covera, eTarka, abanye); kunye ne-telithromycin (ayisafumaneki e-US; Ketek). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba unentsholongwane okanye usandula kwenziwa utyando. Xelela ugqirha wakho ukuba uyatshaya okanye unesifo seswekile, ukubetha kwentliziyo okungaqhelekanga, uxinzelelo lwegazi (uxinzelelo lwegazi), icholesterol ephezulu, iingxaki zokopha, okanye intliziyo, izintso, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, ukuncancisa, okanye ukuba ucwangcisa ukuba ngutata womntwana. Akufanele ukhulelwe ngelixa uthatha ibrutinib. Ukuba ungumfazi, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuba uqale unyango kwaye kufuneka usebenzise ulawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango lwakho kunye ne-ibrutinib kunye nenyanga e-1 emva kokuyeka ukuthatha iyeza. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kunye ne-ibrutinib kwaye niqhubeke inyanga enye emva kwedosi yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa uthatha ibrutinib, biza ugqirha wakho ngokukhawuleza. Ibrutinib inokubangela ingozi yomntwana.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha ibrutinib. Ugqirha wakho angakuxelela ukuba uyeke ukuthatha ibrutinib iintsuku ezi-3 ukuya kwezi-7 phambi kotyando okanye inkqubo.

Musa ukuyitya i-grapefruit okanye ii-orenji ze-Seville (ngamanye amaxesha zisetyenziswa kwi-marmalade), okanye usele ijusi yeziqhamo zomdiliya ngelixa uthatha eli yeza.

Qinisekisa ukuba usela amanzi amaninzi okanye olunye ulwelo yonke imihla ngelixa uthatha ibrutinib.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule ngalo mini. Nangona kunjalo, ukuba awukhumbuli kude kube lusuku olulandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ibrutinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• isicaphucaphu
• ukuqhina
• ukugabha
• isisu esibuhlungu
• Isitshisa okanye isisu
• ukunciphisa ukutya
• ukudinwa kakhulu okanye ubuthathaka
• izihlunu, ithambo, kunye neentlungu ezidibeneyo
• ukudumba kwezihlunu
• ukudumba kwezandla, iinyawo, amaqatha okanye imilenze esezantsi
• irhashalala
• ukurhawuzelela
• izilonda emlonyeni nasemqaleni
• ixhala
• ubunzima bokulala okanye ukulala
• ukukhohlela, ukuvuza okanye impumlo efakiweyo
• ukungaboni kakuhle
• amehlo owomileyo okanye amanzi
• iliso elipinki

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukudumba kobuso, umqala, ulwimi, imilebe namehlo
• ubunzima bokuginya okanye ukuphefumla
• urhwebo
• ukugruzuka okanye ukopha okungaqhelekanga
• umchamo opinki, obomvu, okanye omnyama
• enegazi okanye emnyama, ilindle
• impumlo iyopha
• ukugabha kwegazi; okanye ukugabha igazi okanye izinto ezimdaka ezifana namabala ekofu
• ukuxhuzula
• ukukhawuleza kwentliziyo okanye okungaqhelekanga
• ukuqhawukelwa ngumphefumlo
• Ukungonwabi esifubeni
• ukuba nesiyezi, ukuba nentloko elula okanye ukuziva udimazekile
• utshintsho lombono
• intloko (ehlala ixesha elide)
• umkhuhlane, ukugodola, ukukhohlela, ubomvu, ulusu olufudumeleyo, okanye ezinye iimpawu zosulelo
• ukudideka
• utshintsho kwintetho yakho
• ukuncipha kokuchama
• ukuchama okubuhlungu, rhoqo, okanye okungxamisekileyo

Ibrutinib inokunyusa umngcipheko wokuphuhlisa iintlobo ezithile zomhlaza kubandakanya umhlaza wolusu okanye amanye amalungu. Thetha nogqirha wakho malunga nemingcipheko yokuthatha ibrutinib.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obugqithisileyo kunye nokufuma hayi kwigumbi lokuhlambela.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela iimvavanyo ezithile zebhu kwaye abeke esweni uxinzelelo lwegazi ukujonga impendulo yomzimba wakho kwi-ibrutinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Imbruvica^®