Olaparib

Umxholo

• Ngaphambi kokuba uthathe i-olaparib,
• I-Olaparib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

Amacwecwe e-Olaparib asetyenziselwa ukunceda ukugcina ukuphendula kweentlobo ezithile ze-ovarian (amalungu okuzala ababhinqileyo apho kwenziwa khona amaqanda), ityhubhu (ityhubhu ehambisa amaqanda akhutshwe ngamaqanda esibelekweni), kunye ne-peritoneal (umaleko wethishu eligudle isisu ) umhlaza kubantu abaphendule ngokupheleleyo okanye abasabelayo ngokuyinxenye kunyango lwabo lokuqala okanye lwamva lwe-chemotherapy. Iipilisi zeOlaparib zikwasetyenziselwa ukunyanga iintlobo ezithile zomhlaza wamabele osele unwenwele nakwamanye amalungu omzimba kwaye awuzange uphuculwe okanye uye wanda emva konyango ngezinye iindlela zonyango. Iipilisi zeOlaparib zikwasetyenziselwa ukunyanga uhlobo oluthile lomhlaza webele wendlala osele unwenwele nakwamanye amalungu omzimba, awusaphenduli kunyango okanye kutyando ukunciphisa amanqanaba e testosterone, kwaye uqhubekile emva konyango nge-enzalutamide (Xtandi) okanye i-abiraterone (Yonsa , IZytiga). Amacwecwe e-Olaparib kunye neepilisi njengeliso ukunyanga umhlaza we-ovari ongakhange uphuculwe okanye oye wanda emva konyango kunye nezinye iindlela zonyango ezintathu. Iitafile ze-Olaparib zikwasetyenziselwa ukunceda ukugcina impendulo yohlobo oluthile lomhlaza wepancreatic ongasasazekanga okanye oqhubele phambili emva konyango lokuqala lwe-chemotherapy. I-Olaparib yi-polyadenosine 5'-diphosphoribose polymerase (PARP) ye-enzyme inhibitor. Isebenza ngokubulala iiseli zomhlaza.

I-Olaparib iza njengecwecwe okanye ipilisi yokuthatha ngomlomo kabini yonke imihla kunye okanye ngaphandle kokutya. Zama ukubeka umthamo wakho malunga neeyure ezili-12 ngaphandle. Thatha i-olaparib ngokujikeleza ngamaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-olaparib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya ipilisi okanye ipilisi yonke; musa ukuchoboza ukuhlafuna, ukwahlula, okanye ukuchitha.

I-Olaparib iyafumaneka njengecwecwe kwaye njengephilisi. Amacwecwe kunye neepilisi njengee-olaparib kwaye akufuneki zibekwe endaweni yazo. Thetha nogqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo malunga neethebhulethi kunye nolungiselelo lwecapsule.

Ugqirha wakho unokunciphisa idosi yakho ye-olaparib okanye akuxelele ukuba uyeke ukuthatha i-olaparib kangangexesha elithile kunyango lwakho. Oku kuya kuxhomekeka ekubeni lisebenza njani na iyeza kunye naziphi na iziphumo ebezingalindelekanga onokuzifumana. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-olaparib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-olaparib. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-olaparib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-olaparib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-olaparib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-antibiotics efana ne-ciprofloxacin (Cipro), i-clarithromycin (i-Biaxin, kwi-Prevpac), i-erythromycin (i-EES, i-Erythrocin, abanye), i-nafcillin, kunye ne-telithromycin (ayisekho e-US, Ketek); izinto zokubulala ezifana ne-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); Aprepitant (Hlomela); amayeza athile anyanga ukuxhuzula okufana ne-carbamazepine (Carbatrol, Epitol, Tegretol, Teril), kunye ne phenytoin (Dilantin, Phenytek); i-bosentan (iTracleer); crizotinib (Xalkori); diltiazem (Cardizem, Cartia, Tiazac, nabanye); amayeza athile anyanga i-hepatitis C efana ne-boceprevir (engasafumaneki e-U.S., Victrelis) kunye ne-telaprevir (engasafumanekiyo e-U.S., Incivek); amayeza athile okunyanga intsholongwane kaGawulayo (i-HIV) okanye i-immunodeficiency syndrome (i-AIDS) efana ne-amprenavir (engasekhoyo e-US, Agenerase), atazanavir (Reyataz, e-Evotaz), darunavir (Prezista), efavirenz (Sustiva, e-Atripla) , etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra), kunye ne-saquinavir (Invirase); imatinib (Gleevec); imodafinil (Provigil); nefazodone; amanye amayeza e-chemotherapy omhlaza, i-rifampin (i-Rifadin, i-Rimactane, e-Rifamate, e-Rifater), kunye ne-verapamil (Calan, Verelan, eTarka). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort. Akufanele uthathe i-wort yaseSt.John ngelixa uthatha i-olaparib.
• xelela ugqirha wakho ukuba unengxaki yokuphefumla okanye yokuphefumla, okanye isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ucwangcise ukuba ngutata womntwana. Kuya kufuneka ukuba ube kuvavanyo lokukhulelwa ngaphambi kokuqala unyango, akufuneki ukhulelwe ngelixa uthatha i-olaparib. Kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye ne-olaparib kwaye ubuncinci iinyanga ezi-6 emva kwedosi yokugqibela. Ukuba uyindoda kwaye iqabane lakho linokukhulelwa, kuya kufuneka usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho iipilisi ze-olaparib kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-olaparib, biza ugqirha ngokukhawuleza. U-Olaparib unokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngelixa uthatha i-olaparib kunye nenyanga e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba akufuneki unikele ngesidoda ngelixa uthatha iipilisi ze-olaparib kunye neenyanga ezi-3 emva kwedosi yakho yokugqibela.

Ungayityi i-grapefruit okanye ii-orenji ze-Seville (ngamanye amaxesha zisetyenziswa kwi-marmalade), okanye usele ijusi ye-grapefruit okanye i-Seville orange juice ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Olaparib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• ukugabha
• urhudo
• ukuqhina
• isilungulela
• intloko ebuhlungu
• ukunciphisa ukutya
• umsipha, ukudibana, okanye iintlungu zomqolo
• ukudinwa
• isisu esibuhlungu okanye ukungaphatheki kakuhle
• utshintsho lwencasa
• iintlungu zomlomo okanye izilonda
• ixhala
• ukudakumba
• isikhumba esomileyo
• ukurhawuzelela
• irhashalala
• ubunzima bokulala okanye ukulala
• ukuchama iintlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• umkhuhlane, ukuphefumla kancinci, ukukhohlela okanye ukuvutha
• ukuqhawukelwa ngumphefumlo
• ubuthathaka
• ukudinwa kakhulu
• ukuhla ukusinda
• ukugruzuka okanye ukopha okungaqhelekanga
• ulusu oluthuthu
• igazi kumchamo okanye isitulo
• umkhuhlane, ukugodola, ukukhohlela, umqala obuhlungu, okanye ezinye iimpawu zosulelo
• iintlungu, ukuthamba, ubomvu, okanye ukudumba emlenzeni omnye
• iintlungu zesifuba okanye ukuqina; ukuqhawukelwa ngumphefumlo; ukukhohlela igazi; okanye ukuphefumla ngokukhawuleza

I-Olaparib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho unokuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba imeko yakho inokunyangwa nge-olaparib. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-olaparib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Lynparza^®