I-Riociguat

Umxholo

• Ngaphambi kokuba uthathe i-riociguat,
• I-Riociguat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Musa ukuthatha i-riociguat ukuba ukhulelwe okanye ucwangcise ukukhulelwa. I-Riociguat inokulimaza umntwana ongekazalwa. Ukuba usabelana ngesondo kwaye uyakwazi ukukhulelwa, akufuneki uqale ukuthatha i-riociguat de kuvavanyo lokukhulelwa lubonakalisile ukuba awukhulelwe. Kuya kufuneka usebenzise iindlela ezithembakeleyo zolawulo lokuzalwa ngexesha lonyango kunye nenyanga enye emva kokuyeka i-riociguat. Musa ukwabelana ngesondo ngokungakhuselekanga. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa ezisebenzayo kwaye ziya kukusebenzela. Shayela ugqirha wakho ngokukhawuleza ukuba ulahlekile ixesha lokuya esikhathini okanye ucinga ukuba unokukhulelwa ngelixa uthatha i-riociguat.

Ukuba ungumzali okanye umgcini womntu obhinqileyo ebengekafiki ebusheni, jonga umntwana wakho rhoqo ukuze abone ukuba ngaba ukhula na naziphi na iimpawu zokufikisa (amabele, amabele, kunye neenwele zasesidlangalaleni) kwaye wazise ugqirha wakhe ngalo naluphi na utshintsho. Umntwana wakho unokufikisa ngaphambi kokuba aye exesheni.

Ngenxa yomngcipheko weziphene zokuzalwa, i-riociguat ifumaneka kuphela ngenkqubo ekhethekileyo yokuhambisa. Inkqubo ebizwa ngokuba yiAdempas Risk Evaluation and Mitigation Strategies (REMS) isetelwe zonke izigulana ezingoomama ukuze ziqinisekise ukuba zivavanyelwa ukukhulelwa inyanga nenyanga ngexesha lonyango kunye nenyanga e-1 emva kokumisa i-riociguat. babhalisiwe kwiNkqubo ye-Adempas REMS. Ngexesha lobhaliso uyakukhetha ikhemesti eqinisekisiweyo eya kuthi ithumele amayeza akho kuwe. Buza ugqirha wakho ukuba unemibuzo malunga nokuba uza kuwafumana njani amayeza akho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-riociguat kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-riociguat.

I-Riociguat isetyenziselwa ukunyanga uxinzelelo lwegazi lwe-pulmonary arterial hypertension (PAH; uxinzelelo lwegazi oluphezulu kwimithambo ephethe igazi ukuya emiphungeni). I-Riociguat ikwasetyenziselwa ukunyanga uxinzelelo lwegazi oluphezulu lwe-pulmona (CTEPH; uxinzelelo lwegazi oluphezulu kwimithambo yamaphaphu ebangelwa ligazi elincitshisiweyo okanye elibhloka ukuhamba kwegazi) kubantu abadala abangakwaziyo ukwenza utyando okanye abo baphathwa ngotyando abaqhubeka nokuba negazi eliphezulu lemiphunga. amanqanaba oxinzelelo emva kotyando. I-Riociguat inokuphucula amandla okuzivocavoca kubantu abane-PAH kunye ne-CTEPH kwaye inokunciphisa ukwanda kweempawu kubantu abane-PAH. I-Riociguat ikudidi lwamayeza abizwa ngokuba yi-soluble guanylate cyclase (sGC) evuselelayo. Isebenza ngokuphumla kwimithambo yegazi emiphungeni ukuvumela igazi ukuba liphume ngokulula.

I-Riociguat iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kathathu ngemini. Thatha i-riociguat malunga nexesha elifanayo (ii) yonke imihla kwaye ubeke iidosi zakho malunga neeyure ezi-6 ukuya kwezi-8 ngokwahlukeneyo. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-riociguat ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba awukwazi ukuyiginya ipilisi yonke, unokuyityumza ithebhulethi kwaye udibanise imixholo kunye nenani elincinci lamanzi okanye ukutya okuthambileyo okufana neapilesauce. Gwinya umxube kanye emva kokuba uwuxube.

Ugqirha wakho unokukuqala ngedosi esezantsi ye-riociguat kwaye ngokuthe ngcembe wandise idosi yakho, hayi ngaphezulu kwesinye kwiiveki ezi-2. Ugqirha wakho unokunciphisa umthamo wakho ukuba unemiphumo emibi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-riociguat,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-riociguat, nawaphi na amanye amayeza, okanye naziphi na izithako ezikwiipilisi ze-riociguat. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha okanye usandula ukuthatha i-nitrate efana ne-isosorbide dinitrate (Isordil, kwi-BiDil), isosorbide mononitrate (Monoket), okanye nitroglycerin (Nitro-Dur, Nitromist, Nitrostat, Minitran, Rectiv, others) ,; i-phosphodiesterase inhibitors (PDE-5) efana ne-avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), okanye vardenafil (Levitra, Staxyn); okanye ukuba uthatha idipyridamole (Persantine, kwiAgrenrenox), okanye theophylline (Theo-24, Theochron, Theolair, abanye). Ugqirha wakho uya kukuxelela ukuba ungathathi i-riociguat ukuba uthatha eli okanye la mayeza. Musa ukuthatha i-riociguat ngaphakathi kweeyure ezingama-24 ngaphambi okanye emva kokuthatha i-sildenafil okanye ngaphakathi kweeyure ezingama-24 ngaphambi okanye kwiiyure ezingama-48 emva kokuthatha i-tadalafil.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: i-antitifungal ezifana ne-itraconazole (Onmel, Sporanox) kunye ne-ketoconazole (Extina, Nizoral, Xolegel); I-HIV protease inhibitors kubandakanya i-ritonavir (i-Norvir, e-Kaletra); amayeza athile okubanjwa njenge-carbamazepine (Epitol, Equetro, Tegretol, abanye), phenobarbital, kunye ne phenytoin (iDilantin, Phenytek); kunye namayeza oxinzelelo lwegazi oluphezulu. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• ukuba uthatha ii-antacids ezine-aluminium hydroxide okanye i-magnesium hydroxide (Maalox, Mylanta, Tums, others), zithathe iyure enye ngaphambi okanye iyure e-1 emva kokuthatha i-riociguat.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba une-pulmonary hypertension kunye ne-idiopathic interstitial pneumonia (PH-IIP; isifo semiphunga). Ugqirha wakho uya kukuxelela ukuba ungathathi i-riociguat.
• xelela ugqirha wakho ukuba uyatshaya ngoku okanye uqala okanye uyeke ukutshaya ngexesha lonyango. Xelela ugqirha wakho ukuba ubusandula ukuhambisa, ukugabha, okanye ukubila kakhulu okunokubangela ukomisa (ukulahleka kwenani elikhulu lamanzi omzimba); nakuphi na ukopha kwimiphunga yakho; ukuba unenkqubo yokukuyeka ekukhohleleni igazi; ukuba unoxinzelelo oluphantsi lwegazi, isifo se-veno-occlusive semiphunga (ukuvaleka kwemithambo emiphungeni); okanye intliziyo, isifo, okanye isifo sesibindi.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngelixa uthatha i-riociguat.
• Kuya kufuneka uyazi ukuba i-riociguat inokubangela ukuba ube nesiyezi kunye nokuba nentloko elula. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Ukuba uphose ukuthatha i-riociguat ngaphezulu kweentsuku ezi-3, tsalela umnxeba ugqirha wakho. Ugqirha wakho unokufuna ukuqala kwakhona amayeza akho kwidosi esezantsi.

I-Riociguat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukuqhina
• isilungulela
• isisu esimoshakele
• isicaphucaphu
• ukugabha
• urhudo
• ukudumba kwezandla, imilenze, iinyawo kunye namaqatha

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• ukukhohlela upinki, isikhohlela okanye igazi
• isiqaqa
• iintlungu zesifuba
• ukuqhawukelwa ngumphefumlo

I-Riociguat inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho. Ugqirha wakho uya kujonga uxinzelelo lwegazi rhoqo ngexesha lonyango lwakho nge-riociguat.

Musa ukuvumela nabani na ukuba athathe amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• I-Adempas^®