Ivabradine

Umxholo

• Phambi kokuthatha ivabradine,
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Ivabradine isetyenziselwa ukunyanga abantu abadala abanesifo sentliziyo (imeko apho intliziyo ingakwaziyo ukupompa igazi eloneleyo kwamanye amalungu omzimba) ukunciphisa umngcipheko wokuba imeko yabo iya isiba mandundu kwaye kufuneka inyangwe esibhedlele. Isetyenziselwa ukunyanga uhlobo oluthile lokungaphumeleli kwentliziyo ebantwaneni kwiinyanga ezi-6 ubudala nangaphezulu ngenxa ye-cardiomyopathy (imeko apho izihlunu zentliziyo ziba buthathaka kwaye zandiswe). I-Ivabradine ikwiklasi yamayeza abizwa ngokuba yi-hyperpolarization-activated cyclic nucleotide-gated (HCN) blocker. Isebenza ngokunciphisa ukubetha kwentliziyo ukuze intliziyo ikwazi ukumpompa igazi elininzi emzimbeni ngalo lonke ixesha ibetha.

I-Ivabradine iza njengecwecwe kunye nanjengesisombululo somlomo (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa ngokutya kabini ngemini. Thatha i-ivabradine kumaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ivabradine kanye njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi, okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ezinye iipilisi ze-ivabradine ziza nomgca ophantsi phakathi. Ukuba ugqirha wakho ukuxelela ukuba uthathe isiqingatha sethebhulethi, yaphule ngononophelo emgceni. Thatha isiqingatha sethebhulethi njengoko kuyalelwe, kwaye ugcine esinye isiqingatha sedosi yakho elandelayo.

Sebenzisa isirinji yomlomo (isixhobo sokulinganisa) kunye nekomityi yeyeza ukulinganisa ngokuchanekileyo kwaye uthathe idosi yakho yesisombululo se-ivabradine. Buza usokhemesti wakho ngekomityi yeyeza ukuba ayifakwanga nonyango lwakho. Usokhemesti wakho uya kukunika isirinji yomlomo esebenza ngcono ukulinganisa idosi yakho. Sula sonke isisombululo esivela kwii-ampule (s) kwikomityi yamayeza. Linganisa idosi yakho kwindebe yeyeza usebenzisa isirinji yomlomo. Landela imiyalelo yomenzi malunga nendlela yokusebenzisa nokucoca isirinji yomlomo. Buza ugqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo.

Ukuba uyagabha okanye ukhafule emva kokuthatha i-ivabradine, sukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunyusa okanye anciphise idosi emva kweeveki ezi-2 kuxhomekeke ekubeni lisebenza kanjani na kuwe iyeza, kunye neziphumo ebezingalindelekanga ozifumanayo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-ivabradine.

I-Ivabradine ilawula iimpawu zokusilela kwentliziyo kodwa ayiyinyangi. Qhubeka nokuthatha ivabradine nokuba uziva uphilile. Sukuyeka ukuthatha i-ivabradine ungakhange uthethe nogqirha wakho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ivabradine kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Phambi kokuthatha ivabradine,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-ivabradine, nawaphi na amanye amayeza, okanye ezinye izithako kwiipilisi ze-ivabradine kunye nesisombululo somlomo. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho ukuba uthatha amayeza okubulala iintsholongwane afana ne-clarithromycin (Biaxin, Prevpac) kunye ne-telithromycin (Ketek), ezinye izinto ezibulala ukungunda ezifana ne-itraconazole (i-Onmel, i-Sporanox), i-HIV protease inhibitors ezithile ezifana ne-nelfinavir (i-Viracept) kunye ne-nefazodone. Ugqirha wakho uya kukuxelela ukuba ungathathi i-ivabradine ukuba uthatha elinye okanye ngaphezulu kula mayeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo nolungabhaliswanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qinisekisa ukukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone); ii-beta blockers ezinjenge-atenolol (Tenormin, kwi-Tenoretic), i-carteolol, i-labetalol (iTrandate), i-metoprolol (i-Lopressor, i-Toprol XL, kwi-Dutoprol), i-nadolol (i-Corgard, i-Corzide), i-propranolol (Inderal, i-InnoPran XL, i-Hemangeol, e-Inderide), i-sotalol (iBetapace, iSorine, iSotylize), kunye netimolol; idigoxin (Lanoxin); diltiazem (Cardizem, Cartia, Tiazac, nabanye); phenobarbital; phenytoin (iDilantin, iPhenytek); irifampin (Rifadin, Rifamate, Rifater, Rimactane); kunye neverapamil (Calan, Verelan, eTarka). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-ivabradine, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unesifo esingaqhelekanga okanye esicothayo, uxinzelelo lwegazi, isantya, iimpawu zokwehluleka kwentliziyo ezisandula ukuba mandundu, okanye isifo sesibindi. Ugqirha wakho uya kukuxelela ukuba ungathathi i-ivabradine.
• xelela ugqirha wakho ukuba ukhe wanazo naziphi na iingxaki zentliziyo.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Akufanele ukhulelwe ngelixa uthatha i-ivabradine. Thetha nogqirha wakho ngeendlela zolawulo lokuzalwa onokuzisebenzisa ngexesha lonyango lwakho. Ukuba ukhulelwe ngelixa uthatha ivabradine biza ugqirha wakho.
• Kuya kufuneka uyazi ukuba ivabradine inokuchaphazela umbono wakho, ngakumbi xa ukukhanya kokukhanya okukujikelezile kutshintsha. Oku kunokubandakanya ukubona amabala aqaqambileyo, izangqa eziqaqambileyo ezijikeleze izibane, izibane ezinemibala eqaqambileyo, ukubona kabini, kunye nezinye iingxaki ezingaqhelekanga ngombono wakho. Ezi ngxaki zombono zixhaphake kakhulu xa uqala ukuthatha i-ivabradine kwaye zihlala zihamba emva kweenyanga ezimbalwa zonyango kunye neliyeza. Musa ukuqhuba imoto, ngakumbi ebusuku, okanye usebenzise oomatshini de ube uyazi ukuba lukuchaphazela njani eli yeza.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Ukuba ulibale idosi ye-ivabradine, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ngokukhawuleza, ngokungaqhelekanga, okanye ukubetha kwentliziyo
• ukucotha okanye ukumisa ukubetha kwentliziyo
• iintlungu esifubeni okanye uxinzelelo
• ukwanda komoya omfutshane
• isiyezi
• ukudinwa kakhulu
• ukunqongophala kwamandla
• ukudumba kobuso, umqala, ulwimi, imilebe namehlo
• ubunzima bokuginya okanye ukuphefumla
• ukudinwa

I-Ivabradine inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Lahla nasiphi na isisombululo somlomo esingasetyenziswanga esisele kwikomityi yamayeza okanye kwi-ampule.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• ukubetha kwentliziyo kancinci
• isiyezi
• ukudinwa kakhulu
• ukunqongophala kwamandla

Gcina lonke ixesha lokudibana nogqirha wakho. Ugqirha wakho uya kujonga ukubetha kwentliziyo yakho kunye noxinzelelo lwegazi amaxesha ngamaxesha ukujonga impendulo yomzimba wakho kwi-ivabradine.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Umgangatho^®