IMacitentan

Umxholo

• Ngaphambi kokuba uthathe i-macitentan,
• IMacitentan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-macitentan kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

Kwabaguli ababhinqileyo:

Musa ukuthatha i-macitentan ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Kukho umngcipheko ophezulu wokuba i-macitentan iya kubangela ingozi kwimveku engekazalwa.

Ngenxa yomngcipheko wokonzakala kosana olungekazalwa, inkqubo ebizwa ngokuba yi-OPSUMIT Risk Evaluation and Mitigation Strategy (i-OPSUMIT REMS) sele imiselwe ukuqinisekisa ukuba umfazi okhulelweyo akayithathi imacitentan, kwaye loo mfazi akakhulelwa ngelixa ethatha i-macitentan. Onke amabhinqa, kubandakanya nabasetyhini abangakwaziyo ukukhulelwa, banokufumana kuphela i-macitentan ukuba babhalisiwe kwi-OPSUMIT REMS, banamayeza kugqirha obhaliswe kwi-OPSUMIT REMS, kwaye ugcwalise amayeza kwikhemesti ebhaliswe kwi-OPSUMIT REMS.

Ugqirha wakho uya kukubhalisa kwi-OPSUMIT REMS. Ugqirha wakho uya kukuxelela ngomngcipheko we-macitentan, ngakumbi umngcipheko weziphene zokuzalwa ezinzulu xa uthathwe ukhulelwe. Kufuneka utyikitye iphepha lemvume elinolwazi uchaze ukuba uyayiqonda le nkcukacha ukuze ugqirha wakho akubhalise.

Ugqirha wakho uya kugqiba ukuba uyakwazi ukukhulelwa. Ukuba ufikelele ebusheni (xa umzimba womntwana uya ukhula ngokwasemzimbeni kwaye ukwazi ukuba nomntwana), yiba nesibeleko, kwaye awukagqibi ukuya exesheni ('utshintsho ebomini' lokuphela kwexesha lokuya exesheni) uthathwa njengowasetyhini Ngubani okwaziyo ukukhulelwa, kwaye kuya kufuneka ulandele imigaqo ethile eyongezelelweyo ukuze ufumane i-macitentan.

Kwabasetyhini abakwaziyo ukukhulelwa:

Kuya kufuneka usebenzise ulawulo lokuzalwa oluthembekileyo kunyango lwakho lwe-macitentan, kunye nenyanga e-1 emva kwedosi yakho yokugqibela. Ugqirha wakho uza kukuxelela ukuba zeziphi iintlobo zolawulo lokuzalwa ezamkelekileyo, kwaye uya kukunika ulwazi olubhaliweyo malunga nolawulo lokuzalwa. Kwiimeko ezininzi kuya kufuneka usebenzise iindlela ezimbini zolawulo lokuzalwa ukuthintela ukukhulelwa ngelixa uthatha i-macitentan.

Kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango, inyanga nenyanga ngexesha lonyango, kunye nenyanga e-1 emva kwethamo lakho lokugqibela ukuze ukwazi ukufumana i-macitentan. Ugqirha wakho uya kuku-odola iimvavanyo zokukhulelwa. Ikhemesti ayizukuhambisa macitentan kuwe de baqinisekise ukuba uthathe uvavanyo lwakho lokukhulelwa olufunekayo.

Kuya kufuneka ungabelani ngesondo ngokungakhuselekanga ngelixa uthatha i-macitentan.

Biza ugqirha wakho ngoko nangoko ukuba uye walala ngesondo ngokungakhuselekanga, cinga ukuba ulawulo lwakho lokuzalwa aluphumelelanga, uphulukene nexesha lakho, okanye ucinga ukuba ungakhulelwa nangasiphi na isizathu. Uya kuxoxa nawe ngokhetho lwakho lwezonyango. Musa ukulinda de kuqeshwe ixesha elizayo ukuze uxoxe ngale nto nogqirha wakho.

Xelela ugqirha wakho ukuba awuyiqondi yonke into obuyixelelwe malunga nolawulo lokuzalwa, okanye ukuba awucingi ukuba uza kukwazi ukusebenzisa iindlela ezamkelekileyo zolawulo lokuzalwa ngalo lonke ixesha ngexesha lonyango lwakho.

Ukuba ungumzali okanye umgcini womntu obhinqileyo ebengekafiki ebusheni, jonga umntwana wakho rhoqo ukuze abone ukuba ngaba ukhula na naziphi na iimpawu zokufikisa (amabele, amabele, kunye neenwele zasesidlangalaleni) kwaye wazise ugqirha wakhe ngalo naluphi na utshintsho.

Zonke izigulana:

IMacitentan ayifumaneki kwiivenkile ezithengisa iimpahla. Amayeza akho aya kuthunyelwa ngeposi kwikhemesti ekhethekileyo ebhaliswe kwi-OPSUMIT REMS. Ukuba ungumfazi ongafikanga ebusheni okanye owasetyhini okwaziyo ukukhulelwa uyakufumana kuphela ukubonelelwa kweentsuku ezingama-30 ngexesha. Buza ugqirha wakho ukuba unemibuzo malunga nokuba uza kuwafumana njani amayeza akho.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-macitentan kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

IMacitentan isetyenziselwa ukulawula iimpawu ze-pulmonary arterial hypertension (PAH; uxinzelelo lwegazi oluphezulu kwimithambo ephethe igazi liye emiphungeni). IMacitentan ikudidi lwamayeza abizwa ngokuba zi-endothelin receptor antagonists. Isebenza ngokumisa isenzo se-endothelin, into yendalo ebangela ukuba imithambo yegazi icuthe kwaye ithintele ukuhamba kwegazi okuqhelekileyo kubantu abane-PAH.

IMacitentan iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngemini. Thatha i-macitentan ngeenxa zonke yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-macitentan ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-macitentan,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-macitentan, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-macitentan. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), clarithromycin (Biaxin, kwi-Prevpac); I-efavirenz (iSustiva); inhibitors ezithile ze-HIV ezifana ne-nelfinavir (Viracept), indinavir (Crixivan), kunye ne-ritonavir (Norvir, e-Kaletra); itraconazole (Onmel, Sporanox); ketoconazole; nefazodone; nevirapine Viramune); phenobarbital; phenytoin (iDilantin, iPhenytek); irifabutin (Mycobutin); kunye nerifampin (Rifadin, Rifamate, Rifater, Rimactane). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-macitentan, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unayo okanye wakhe wanayo i-anemia (imeko apho iiseli ezibomvu zegazi zingazisi ioksijini eyaneleyo kumalungu) okanye isifo sesibindi.
• Musa ukuncancisa ngelixa uthatha la mayeza.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-macitentan.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IMacitentan inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• Impumlo exineneyo
• umqala obuhkungu
• ukukhohlela
• umkhuhlane njengeempawu
• intloko ebuhlungu
• Ukuchama okungxamisekileyo, rhoqo, okanye okubuhlungu
• irhashalala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukuthatha i-macitentan kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ukurhawuzelela ulusu
• umchamo omnyama
• mthubi ulusu lwakho okanye amehlo
• iintlungu kwindawo ephezulu yesisu sakho
• isicaphucaphu esingachazwanga okanye ukugabha
• Ukuphelelwa ngumdla wokutya
• ukudinwa kakhulu
• ifiva
• ukudumba kobuso, umqala, ulwimi, imilebe namehlo
• ubunzima bokuginya okanye ukuphefumla
• ukudinwa
• ukuphefumla kancinci, ngakumbi xa ulele phantsi
• ukukhohlela upinki, isikhohlela okanye igazi
• ukwanda kobunzima obungaqhelekanga
• ukudumba kwamaqatha okanye imilenze

IMacitentan inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• intloko ebuhlungu
• isicaphucaphu
• ukugabha

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho angayalela iimvavanyo ukuze abone ukuba isibindi sakho sisebenza kakuhle kangakanani, kwaye ujonge i-anemia ngaphambi kokuqala unyango kwaye amaxesha ngamaxesha kunyango lwakho nge-macitentan.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Opsumit^®