Inaliti ye-Evolocumab

Umxholo

• Ngaphambi kokusebenzisa inaliti ye-evolocumab,
• Inaliti ye-Evolocumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukusebenzisa inaliti ye-evolocumab kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

Inaliti ye-Evolocumab isetyenziselwa ukunciphisa umngcipheko wokubetha okanye ukubetha kwentliziyo okanye isidingo sotyando lwe-coronary artery (CABG) kubantu abanesifo sentliziyo. Inaliti ye-Evolocumab ikwasetyenziswa kunye nokutya kuphela okanye ngokudibeneyo namanye amayeza anciphisa i-cholesterol njenge-HMG-CoA reductase inhibitors (i-statins) okanye i-ezetimbe (i-Zetia) ukunciphisa inani le-cholesterol encinci ye-lipoprotein (LDL) ('cholesterol embi ') egazini, kubandakanya abantu abane-heterozygous hypercholesterolemia (HeFH; imeko ezuzwe njengelifa apho i-cholesterol ayinakususwa emzimbeni ngesiqhelo). Ikwasetyenziswa kunye notshintsho kwindlela yokutya kunye nolunye unyango ukunciphisa isixa esisezantsi se-lipoprotein (LDL) ye-cholesterol ('cholesterol embi') egazini kubantu abane-homozygous Family hypercholesterolemia (HoFH; imeko ezuzwe njengelifa apho i-cholesterol ayinakubakhona isuswe emzimbeni ngesiqhelo). Inaliti ye-Evolocumab ikudidi lwamayeza abizwa ngokuba yiprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibody. Isebenza ngokuthintela ukuveliswa kwe-cholesterol ye-LDL emzimbeni ukunciphisa inani le-cholesterol enokwakha kwiindonga zemithambo kunye nokuvimba ukuhamba kwegazi ukuya entliziyweni, kwingqondo nakwamanye amalungu omzimba.

Ukuqokelelwa kwecholesterol ezindongeni zemithambo yakho (inkqubo eyaziwa njenge-atherosclerosis) kunciphisa ukuhamba kwegazi kwaye, ke, unikezelo lweoksijini entliziyweni yakho, kwingqondo nakwamanye amalungu omzimba wakho.

Inaliti ye-Evolocumab iza njengesisombululo (ulwelo) kwisirinji ekhethiweyo, i-autoinjector ekhethiweyo, nakwi-infusor esemzimbeni eneqokobhe eligcwalisiweyo lokufaka ngaphakathi (phantsi kolusu). Xa inaliti ye-evolocumab isetyenziselwa ukunyanga i-HeFH okanye isifo sentliziyo okanye ukunciphisa umngcipheko wokubetha, isifo sentliziyo, kunye nokuhlinzwa kotyando lwe-coronary, ihlala itofwa rhoqo kwiiveki ezi-2 okanye kube kanye ngenyanga. Xa inaliti ye-evolocumab isetyenziselwa ukunyanga i-HoFH, ihlala itofwa kanye ngenyanga. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Sebenzisa inaliti ye-evolocumab kanye njengoko kuyalelwe. Sukusebenzisa ngaphezulu okanye ngaphantsi kweli yeza okanye ulisebenzise rhoqo okanye ixesha elide kunokuba umiselwe ngugqirha.

Ukuba usebenzisa inaliti ye-evolocumab kanye ngenyanga (i-420 mg yedosi), yitofa kanye ngaphezulu kwemizuzu eli-9 nge-infusor yomzimba kunye necartridge ekhethiweyo yenaliti nganye okanye ngenise inaliti ezi-3 ezahlukileyo enye nenye ngaphakathi kwemizuzu engama-30, usebenzisa eyahlukileyo ekhethiweyo isirinji okanye i-autoinjector ekhethiweyo yenaliti nganye.

Inaliti ye-Evolocumab inceda ukulawula amanqanaba e-cholesterol kunye nokunciphisa umngcipheko wokubetha, ukuhlaselwa yintliziyo, okanye i-coronary artery yokuhlinzwa, kodwa ayiyikunyanga le miqathango okanye isuse le mngcipheko. Qhubeka nokusebenzisa inaliti ye-evolocumab nokuba uziva uphilile. Sukuyeka ukusebenzisa inaliti ye-evolocumab ngaphandle kokuthetha nogqirha wakho.

Inaliti ye-Evolocumab iza kwi-autoinjector ekhethiweyo, iisirinji ezikhethiweyo, nakwi-infusor ene-cartridge ekhethiweyo equlathe amayeza awoneleyo kwithamo elinye. Ngamaxesha onke jofa i-evolocumab kwindawo yayo yokuzenzekelayo, isirinji, okanye i-infusor nge-cartridge ekhethiweyo; ungaze uyidibanise namanye amayeza. Lahla iinaliti ezisetyenzisiweyo, iisirinji kunye nezixhobo kwisitya esinganyangekiyo. Thetha nogqirha wakho okanye usokhemesti malunga nokusilahla isikhongozeli esinganyangekiyo.

Unokufaka inaliti ye-evolocumab phantsi kolusu emathangeni okanye kwindawo yesisu, ngaphandle kwendawo ye-intshi ezi-2 ejikeleze inkaba yakho (iqhosha lesisu). Ukuba omnye umntu uya kukujolela iyeza, loo mntu unokulifaka engalweni yakho ephezulu. Sebenzisa indawo eyahlukileyo yenaliti nganye. Musa ukufaka inaliti ye-evolocumab kwindawo ethenda, etyumkileyo, ebomvu okanye enzima. Kwakhona, musa ukujova kwiindawo ezinamanxeba okanye ezolula amanqaku.

Yifundisise ngononophelo imiyalelo yomenzi esetyenziswa nonyango. Le miyalelo ichaza indlela yokufaka inaliti yedosi yenaliti ye-evolocumab. Qiniseka ukuba ubuza usokhemesti wakho okanye ugqirha ukuba wena okanye umntu oza kungenza inaliti unemibuzo malunga nokuba ungalifaka njani na eliyeza. Yabona Imiyalelo yokusebenzisa ukusuka kumenzi https://bit.ly/3jTG7cx.

Susa isirinji ekhethiweyo okanye i-autoinjector ekhethiweyo kwifriji kwaye uyivumele ifudumale kubushushu begumbi kangangemizuzu engama-30 ngaphambi kokuyisebenzisa. Susa i-infusor nge-cartridge ekhethiweyo evela kwifriji kwaye uyivumele ifudumale kwigumbi lobushushu kangangemizuzu engama-45 ngaphambi kokuyisebenzisa. Musa ukufudumeza inaliti ye-evolocumab emanzini ashushu, kwimicrowave, okanye uyibeke elangeni.

Ngaphambi kokuba usebenzise inaliti ye-evolocumab, jonga isisombululo kufutshane. Iyeza kufuneka licace mthubi mthubi kwaye lingenazinto zidadayo. Musa ukushukumisa isirinji ekhethiweyo, i-autoinjector ekhethiweyo, okanye i-infusor enekhatriji ekhethiweyo equkethe inaliti ye-evolocumab.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti ye-evolocumab,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa inaliti ye-evolocumab, nawaphi na amanye amayeza, i-latex, irabha, okanye naziphi na izithako kwiinaliti ye-evolocumab. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe wakha naziphi na iimeko zonyango.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Ukuba ukhulelwa ngelixa usebenzisa inaliti ye-evolocumab, tsalela ugqirha wakho.

Yitya ukutya okune-fat-fat, low-cholesterol. Qiniseka ukuba ulandela yonke imithambo kunye nezincomo zokutya ezenziwe ngugqirha wakho okanye ugqirha otya ukutya. Ungandwendwela iNational Cholesterol Education Programme (NCEP) kwiwebhusayithi ukufumana ulwazi olongezelelekileyo malunga nokutya kule dilesi: http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Ukuba ulawula inaliti ye-evolocumab qho emva kweeveki ezi-2 kwaye ukuba zingaphakathi kweentsuku ezisi-7 ukusuka kwidosi yakho oyiphosileyo, yitofe ngokukhawuleza nje ukuba uyikhumbule kwaye uqhubeke neshedyuli yakho yesiqhelo. Nangona kunjalo, ukuba kukho ngaphezulu kweentsuku ezisi-7 ukusuka kwidosi yakho ephosiweyo, yeqe kwaye uqhubeke neshedyuli yakho yethosi eqhelekileyo. Musa ukufaka idosi ephindwe kabini ukwenza idosi ephosiweyo. Biza ugqirha wakho ukuba uphose idosi kwaye unemibuzo malunga nokwenza.

Ukuba ulawula inaliti ye-evolocumab kanye ngenyanga kwaye ukuba zingaphakathi kweentsuku ezisi-7 ukusuka kwidosi yakho oyiphosileyo, yitofe ngokukhawuleza nje ukuba uyikhumbule kwaye uqhubeke neshedyuli yakho yesiqhelo. Nangona kunjalo, ukuba ulawula inaliti ye-evolocumab kanye ngenyanga kwaye kukho ngaphezulu kweentsuku ezisi-7 ukusuka kwidosi yakho ephosiweyo, yitofe kwangoko kwaye uqalise ishedyuli entsha yethamo ngokusekwe kulo mhla. Musa ukufaka idosi ephindwe kabini ukwenza idosi ephosiweyo. Biza ugqirha wakho ukuba uphose idosi kwaye unemibuzo malunga nokwenza.

Inaliti ye-Evolocumab inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ubomvu, ukurhawuzelela, ukudumba, iintlungu, okanye ukuthamba kwindawo yenaliti
• Iimpawu ezinjengomkhuhlane, impumlo ebusayo, umqala obuhlungu, umkhuhlane, okanye ukugodola
• intlungu okanye ukutshisa ngexesha lokuchama
• iintlungu zemisipha okanye yomqolo
• isiyezi
• isisu esibuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, yeka ukusebenzisa inaliti ye-evolocumab kwaye ubize ugqirha ngoko nangoko okanye ufumane unyango olungxamisekileyo:

• ukurhawuzelela
• irhashalala
• urhwebo
• ubunzima bokuphefumla okanye ukugwinya
• ukudumba kobuso, umqala, ulwimi, imilebe namehlo

Inaliti ye-Evolocumab inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa usebenzisa eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kwifriji, kodwa ungayiginyi. Sukuyishiya inaliti ye-evolocumab ngaphandle kwefriji ngaphezulu kweentsuku ezingama-30. Inaliti ye-Evolocumab inokugcinwa kubushushu begumbi kwiibhokisi zokuqala ukuya kwiintsuku ezingama-30. Gcina inaliti ye-evolocumab kude nokukhanya ngokuthe ngqo.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ukujonga impendulo yomzimba wakho kwinaliti ye-evolocumab.

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nenaliti ye-evolocumab.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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