Cobimetinib

Umxholo

• Ngaphambi kokuba uthathe i-cobimetinib,
• I-Cobimetinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Cobimetinib isetyenziswa kunye ne-vemurafenib (iZelboraf) ukunyanga iintlobo ezithile ze-melanoma (uhlobo lomhlaza wolusu) olungenakunyangwa ngoqhaqho okanye olunwenwe kwamanye amalungu omzimba. UCobimetinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

I-Cobimetinib iza njengecwecwe lokuthatha ngomlomo kunye nangaphandle kokutya. Ihlala ithathwa kanye yonke imihla kwiintsuku ezingama-21 zokuqala komjikelo weentsuku ezingama-28. Thatha i-cobimetinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-cobimetinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ukuba uyagabha emva kokuthatha i-cobimetinib ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunciphisa idosi yakho ye-cobimetinib okanye ngokusisigxina okanye okwexeshana uyeke unyango lwakho. Oku kuxhomekeke ekusebenzeni kakuhle kweyeza kunye neziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-cobimetinib.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-cobimetinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-cobimetinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-cobimetinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: Atripla), erythromycin (EES, E-Mycin, Erythrocin), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Ketozole, Nizoral), nefazodone, nelfinavir (Viracept), phenytoin Difin (Rifadin, Rimactane, eRifamate, eRifater), kunye ne-ritonavir (Norvir, eKaletra, eViekira Pak). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-cobimetinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort. Musa ukuthatha iSort John's Wort ngelixa uthatha i-cobimetinib.
• xelela ugqirha wakho ukuba ubukhe wanazo iimeko zolusu ngaphandle kwemelanoma; iingxaki zokopha; iingxaki zombono; nayiphi na imeko echaphazela izihlunu zakho; okanye isifo sentliziyo okanye sesibindi.
• Kuya kufuneka uyazi ukuba i-cobimetinib inokunciphisa ukuzala emadodeni nakwabasetyhini. Nangona kunjalo, awufanelanga ukucinga ukuba wena okanye iqabane lakho aninakukhulelwa. Tshela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Sebenzisa indlela ethembekileyo yolawulo lokuzalwa ukukhusela ukukhulelwa ngexesha lonyango kunye nakwiiveki ezi-2 emva kokuba uyeke ukuthatha i-cobimetinib. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha i-cobimetinib, biza ugqirha wakho ngokukhawuleza. I-Cobimetinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha i-cobimetinib kunye neeveki ezi-2 emva kwedosi yakho yokugqibela.
• cwangcisa ukuthintela ukukhanya elangeni okungeyomfuneko okanye ixesha elide kunye nokunxiba impahla ekhuselayo, iiglasi zelanga, i-lip balm kunye ne-sunscreen (i-SPF 30 okanye ngaphezulu). I-Cobimetinib inokwenza ulusu lwakho lubuthathaka kwilanga.

Musa ukuyitya i-grapefruit okanye usele ijusi yeziqhamo ngelixa uthatha eli yeza.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Cobimetinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• izilonda zomlomo
• ukulahleka kweenwele
• urhudo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• irhashalala egubungela indawo enkulu yomzimba wakho, iblisters, okanye isikhumba esikhulayo
• utshintsho kwinkangeleko yesikhumba
• intsumpa entsha
• ulusu lubuhlungu okanye iqhuma elibomvu elopha okanye lingapholi
• utshintsho kubungakanani okanye umbala kwimole
• ukopha okungaqhelekanga okanye ukugruzuka
• ilindle okanye ilindle elimnyama
• igazi kumchamo
• ukopha okungaqhelekanga kwilungu lobufazi
• intloko ebuhlungu
• isiyezi
• ukukhawuleza kwentliziyo, ukungahambi kakuhle, okanye ukubetha kwentliziyo
• ukukhohlela okanye ukuvuthisa
• ukuqhawukelwa ngumphefumlo
• ukudumba kobuso, iingalo, imilenze, amaqatha okanye iinyawo
• ukudinwa
• iintlungu zemisipha okanye ubuthathaka
• Utshintsho kumbono, kubandakanya ukubona ii-halos (ulwandlalo olungqamene ngokujikeleza izinto)
• mthubi ulusu okanye amehlo
• umchamo wombala omnyama (umbala weti)
• iintlungu kwindawo ephezulu yesisu
• isicaphucaphu
• ukugabha
• Ukuphelelwa ngumdla wokutya

I-Cobimetinib inokunyusa umngcipheko wokuba ube nomhlaza wolusu omtsha. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Cobimetinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ukujonga impendulo yomzimba wakho ngexesha nasemva konyango. Ugqirha wakho uya kujonga ulusu lwakho kulo naluphi na utshintsho ngaphambili, rhoqo kwiinyanga ezi-2 ngexesha lonyango lwakho, kwaye ukuya kuthi ga kwiinyanga ezi-6 emva konyango.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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